UPF1 and CNN1

		UPF1	CNN1
Description		UPF1 RNA helicase and ATPase	calponin 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin P-body Nucleus Nucleoplasm Cytoplasm Cytosol Exon-exon Junction Complex Supraspliceosomal Complex Perinuclear Region Of Cytoplasm	Cytoskeleton Focal Adhesion Actin Cytoskeleton
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Double-stranded DNA Helicase Activity Telomeric DNA Binding Protein-containing Complex Binding Metal Ion Binding	Actin Binding Protein Binding Calmodulin Binding Actin Filament Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process DNA Replication DNA Repair MRNA Export From Nucleus Regulation Of Translational Termination Regulation Of Gene Expression Telomere Maintenance Via Semi-conservative Replication Regulation Of Telomere Maintenance Cell Cycle Phase Transition Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Histone MRNA Catabolic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Cis Splicing, Via Spliceosome	Regulation Of Smooth Muscle Contraction Actin Filament Organization Actomyosin Structure Organization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 32595297)	Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		106 interacting genes: ABHD16A ACSS2 ATR CEBPA CSNK2B DCP1A DCP2 DXO EIF3A EIF3B EIF4A3 EXOSC2 EXOSC4 GNPTG HIRA LINC00113 LSM8 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NADSYN1 NDRG1 NDUFB10 PLEKHA5 PLEKHB2 POLR2A PTEN RHOXF2 RNF10 RPRD2 SMG1 SMG5 STAU1 SUMO2 UPF2 UPF3A UPF3B XRN1	15 interacting genes: ACTA1 ADRB2 CALM1 CCHCR1 COG6 DNMBP FYN MYO1A NCAPD2 PLRG1 PRKCE SYCE1 TFPT TPM3 TUBB
Entrez ID		5976	1264
HPRD ID		03254	02884
Ensembl ID		ENSG00000005007	ENSG00000130176
Uniprot IDs		A0A024R7L5 B3KY55 Q92900	B7Z7E1 P51911 Q53FP8 V9HWA5
PDB IDs		2GJK 2GK6 2GK7 2IYK 2WJV 2WJY 2XZO 2XZP 6EJ5 6Z3R 8RXB	1WYP
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression RNA Destabilization MRNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of Translation Negative Regulation Of Locomotion Regulation Of Metabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Angiogenesis Regulation Of RNA Stability Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Motility Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus	Actin Filament Chromosome Organization Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cell Body Mitotic Chromosome Condensation Cellular Response To Prostaglandin E Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To Prostaglandin Stimulus Regulation Of Metal Ion Transport Response To Prostaglandin E Mitotic Cell Cycle Protein-containing Complex Binding Regulation Of Calcium Ion Transmembrane Transport Cell Cycle Phase Transition Fc-gamma Receptor Signaling Pathway Condensed Chromosome Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Monoatomic Ion Transport Innate Immune Response-activating Signaling Pathway Cellular Response To Glycine Response To Singlet Oxygen Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Chromosome Condensation Cell Division Muscle Contraction Glutamate Receptor Signaling Pathway Cellular Response To Amyloid-beta Activation Of Innate Immune Response Cytoplasm Sarcomere Cellular Response To Oxygen-containing Compound Positive Regulation Of Organelle Organization Modulation Of Chemical Synaptic Transmission Cell Cycle G2/M Phase Transition Regulation Of Calcium Ion Transport Fc Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Chromosome Organization Involved In Meiotic Cell Cycle Response To Amyloid-beta Beta2-adrenergic Receptor Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Glycine Ethanol Binding Regulation Of Chromosome Organization Muscle System Process
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