LMNA and TNFSF12

Number of citations of the paper that reports this interaction (PubMedID 24623722)
69

Data Source:
BioGRID (two hybrid)

		LMNA	TNFSF12
Description		lamin A/C	TNF superfamily member 12
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Lamin Filament Nuclear Lamina Nucleoplasm Cytosol Intermediate Filament Nuclear Matrix Nuclear Speck Nuclear Membrane Nuclear Lumen Site Of Double-strand Break Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Identical Protein Binding Structural Constituent Of Nuclear Lamina	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Protein Import Into Nucleus Nucleus Organization Nuclear Envelope Organization Nuclear Migration Muscle Organ Development Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Cell Migration Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Heterochromatin Formation Regulation Of Protein Stability Regulation Of Telomere Maintenance Protein Localization To Nucleus Nuclear Pore Localization Ventricular Cardiac Muscle Cell Development Cellular Response To Hypoxia Negative Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Senescence Protein Localization To Nuclear Envelope Regulation Of Protein Localization To Nucleus Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress DNA Double-strand Break Attachment To Nuclear Envelope Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Apoptotic Process Immune Response Signal Transduction Cell Differentiation Endothelial Cell Migration Positive Regulation Of Protein Catabolic Process Positive Regulation Of Angiogenesis Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		XBP1(S) activates chaperone genes Signaling by BRAF and RAF1 fusions	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases		Mandibuloacral dysplasia Familial partial lipodystrophy (FPL), including the following four diseases: Kobberling-type lipodystrophy (FPLD1); Dunnigan-type lipodystrophy (FPLD2); Dunnigan-like lipodystrophy (FPLD3); AKT2 associated lipodystrophy Emery-Dreifuss muscular dystrophy Dilated cardiomyopathy (DCM) Limb-girdle muscular dystrophy (LGMD) Hutchinson-Gilford progeria syndrome Restrictive dermopathy Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Heel bone mineral density x serum urate levels interaction ( 34046847) Hip index ( 34021172) Ischemic heart disease in rheumatoid arthritis ( 30251476) Lung cancer in ever smokers ( 28604730) Monocyte count ( 32888494) Neutrophil count ( 32888494) Ovarian cancer ( 30557369) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) White blood cell count ( 32888494)	Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 29892015 30061737) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Emotional recognition ( 31596458) HDL cholesterol levels ( 32203549) Myopia ( 27182965) Plateletcrit ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		381 interacting genes: ABCA9 ACOT7 ACTB ADAM33 ADGRE2 ADGRG7 AGTRAP AIG1 AKTIP ALG3 ALG8 ALOX12 ALOX12B ANKRD20A5P ANXA1 AOC3 APOA2 APOD APOL2 AQP1 AQP10 AQP3 ARHGEF16 ARL6IP1 ARLN ASGR1 ATP6V0C BCL2L2 BNIP2 BNIP3 BNIP3L BRICD5 BTN2A2 BYSL C11orf24 C1QTNF1 C20orf141 C3orf52 C5 CACNG1 CASP1 CASP6 CCDC120 CCNG1 CD52 CD72 CD81 CDK1 CDS2 CENPP CETN3 CFHR5 CHST1 CLCA4 CLDN10 CLDND2 CLEC1A CLEC4A CLK1 CLN6 CMTM3 CMTM5 CMTM7 CNIH3 COL8A2 COX14 CREB3 CRY2 CSGALNACT2 CTSA CWF19L2 CXCL14 CXCL16 CYB561 CYB561D2 CYB5B CYBC1 CYBRD1 DBNDD2 DDX24 DDX43 DEFB127 DERL1 DERL2 DNAJC30 DUS3L DUSP13B EDDM3B EGF EIF3G EIF4ENIF1 ELOA EMD ENTPD3 ERG28 F2RL1 FA2H FAIM FAM161A FAM3C FAM9B FATE1 FAXDC2 FBXO7 FCER1A FCER1G FDFT1 FETUB FLNA FOS FXYD3 FXYD6 GALNT2 GIN1 GJB2 GJB5 GOLGA2P10 GOLT1B GOSR2 GPR108 GPR25 GRM2 GZMA GZMB HACD1 HCK HMOX1 IFFO1 IFIT2 IGFBP5 INSIG2 ITGAM ITM2B IZUMO2 JAGN1 KASH5 KAT5 KCNK1 KCNK13 KIF12 KPNA6 KRT6A KRTAP10-3 KRTAP10-7 LAMB1 LAT LCP2 LEPROTL1 LHFPL5 LIMS2 LINC01587 LMBR1 LMNB1 LPAR3 LRP10 LVRN MAL MALL MAPRE2 MARVELD1 MATR3 MCM5 MEOX1 MFAP1 MGLL MGST3 MIP MLIP MMD2 MORF4L1 MRPS26 MS4A1 MTHFD2 MUTYH MYADM NAB2 NALCN NARF NAT8 NEU1 NINJ2 NIPAL3 NKG7 NOD2 NTAQ1 OGT ORMDL1 ORMDL3 OSBPL8 OSTCP1 OSTF1 PAQR5 PARPBP PCBP1 PCGF2 PELI1 PERM1 PIAS2 PIK3R2 PKD2 PLLP PLP1 PLP2 PLPP4 PMP22 PNKP PNLIPRP1 PRELID3A PRKCA PRPF6 PTPN9 PYGM RABAC1 RANBP9 RB1 RBBP4 RBFOX2 REEP6 RGS18 RHAG RMDN2 RNF123 RPRM RTN1 RTN3 RTN4 RUSF1 SACM1L SBDS SCARA3 SCARB2 SEC22A SEC22B SELENOK SENP2 SERP1 SERP2 SERPINE1 SFT2D2 SFTPC SGMS2 SH3RF2 SIAH1 SLC13A3 SLC1A1 SLC26A4-AS1 SLC2A5 SLC30A2 SLC30A3 SLC30A8 SLC35A1 SLC35A4 SLC35B2 SLC35B4 SLC38A7 SLC41A2 SLC61A1 SLC7A1 SLN SLU7 SMAD1 SMAD3 SMCO4 SMIM11 SMURF1 SMURF2 SNORC SPANXC SPANXD SPG21 SPN SREBF1 SRPK2 STAC STAC2 STARD3 STX12 STX3 STX4 STX5 STX6 STX7 STX8 SUMO2 SUMO4 SVIL SYNE1 SYNGR1 SYPL1 SYT6 TAP1 TCEA2 TCEANC TDO2 TFIP11 TFRC THBD TM4SF20 TMEM107 TMEM109 TMEM11 TMEM120B TMEM128 TMEM140 TMEM14A TMEM14B TMEM14C TMEM201 TMEM203 TMEM208 TMEM218 TMEM222 TMEM230 TMEM234 TMEM243 TMEM267 TMEM41A TMEM42 TMEM43 TMEM51 TMEM54 TMEM60 TMEM65 TMEM74 TMEM86A TMPO TMPRSS4 TNF TNFRSF10C TNFSF12 TNMD TOR1A TOR1AIP1 TRAM1L1 TRIM26 TRIM39 TSGA10 TSNARE1 TSPAN2 TSPAN33 TSPAN7 UBE2I UBE2Q1 UBQLNL UCHL5 UNC13D UNC45A UNC50 UPK1B URB2 USE1 USP2 USP20 VAMP1 VAMP2 VAMP3 VAMP5 VKORC1 VMA12 VMP1 VSTM1 VTI1B WFDC2 YIPF1 YIPF6 YWHAQ ZC2HC1C ZDHHC15 ZDHHC24 ZMYM6 ZNF138 ZNF239 ZNF25 ZNF3 ZNF439 ZNF440 ZNF490 ZNF564 ZNF569 ZNF69 ZSCAN12	6 interacting genes: AGGF1 DDIT3 LMNA SGTA TNFRSF12A TNFRSF25
Entrez ID		4000	8742
HPRD ID		01035	04074
Ensembl ID		ENSG00000160789	ENSG00000239697
Uniprot IDs		A0A384MQX1 H0YAB0 P02545 Q5TCI8	O43508 Q4ACW9
PDB IDs		1IFR 1IVT 1X8Y 2XV5 2YPT 3GEF 3V4Q 3V4W 3V5B 6GHD 6JLB 6RPR 6SNZ 6YF5 6YJD 7CRG 7D9N 7WZZ 7X1B 7X5D 7YVD 7Z21 8I33 9J8M 9J8N 9J8O	4HT1
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane SNAP Receptor Activity Protein Binding Membrane Organization SNARE Complex Endoplasmic Reticulum Nuclear Inner Membrane Endomembrane System SNARE Binding Lamin Binding Vesicle Fusion Membrane Fusion Organelle Membrane Fusion Vesicle Docking Intracellular Protein Localization Organelle Fusion Structural Constituent Of Myelin Sheath Organelle Localization By Membrane Tethering Nuclear Envelope Endoplasmic Reticulum Tubular Network Formation Membrane Docking Regulation Of Protein Localization Establishment Of Protein Localization Secretion By Cell Ascorbate Homeostasis Regulation Of Protein Localization To Plasma Membrane Endoplasmic Reticulum Tubular Network Membrane Organization Leukocyte Degranulation Regulation Of Protein Localization To Membrane Protein Transport Transmembrane Monodehydroascorbate Reductase Activity Respiratory Burst After Phagocytosis Golgi Membrane Regulation Of Protein Localization To Cell Periphery Myelination Regulation Of Cellular Localization Vesicle Recycling Endosome Axon Ensheathment Endoplasmic Reticulum Tubular Network Organization Defense Response Positive Regulation Of Transport Regulation Of Transport Identical Protein Binding Vesicle-mediated Transport Granzyme-mediated Programmed Cell Death Signaling Pathway Nuclear Membrane Organization SNARE Complex Assembly Intracellular Sphingolipid Homeostasis	Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Determination Of Dorsal Identity Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress CHOP-ATF4 Complex CHOP-ATF3 Complex Apoptotic Signaling Pathway Establishment Of Protein Localization To Organelle DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina TRC Complex Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Apoptotic Signaling Pathway Involuntary Skeletal Muscle Contraction CHOP-C/EBP Complex Diaphragm Contraction Cellular Response To Nitrosative Stress Identical Protein Binding Vascular Associated Smooth Muscle Cell Migration Regulation Of Extrinsic Apoptotic Signaling Pathway Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity BAT3 Complex Binding GDF15-GFRAL Signaling Pathway Lamin Filament Nuclear Pore Localization Cell Death ATF6-mediated Unfolded Protein Response HRI-mediated Signaling Apoptotic Process Response To Endoplasmic Reticulum Stress Blood Vessel Maturation Negative Regulation Of Interleukin-4 Production Response To Nitrosative Stress Programmed Cell Death Smooth Muscle Cell Proliferation Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of ERAD Pathway Transcription Regulator Activator Activity PERK-mediated Unfolded Protein Response ER Overload Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway CAMP Response Element Binding Protein Binding Response To Caloric Restriction Leucine Zipper Domain Binding Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
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