RASGRF1 and SNRNP70

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RASGRF1	SNRNP70
Description		Ras protein specific guanine nucleotide releasing factor 1	small nuclear ribonucleoprotein U1 subunit 70
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Growth Cone Neuron Projection	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck Lysosomal Lumen U2-type Prespliceosome Ribonucleoprotein Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Glutamate Receptor Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding U1 SnRNA Binding U1 SnRNP Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Long-term Memory Neuron Projection Development Response To Endoplasmic Reticulum Stress Positive Regulation Of Rac Protein Signal Transduction Intracellular Signal Transduction Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Type B Pancreatic Cell Proliferation Regulation Of Ras Protein Signal Transduction Positive Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity	MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Refolding Cellular Response To Retinoic Acid Cellular Response To Tumor Necrosis Factor Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Chaperone-mediated Autophagy
Pathways		Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Adult body size ( 32376654) Bronchopulmonary dysplasia ( 23897914) Hand grip strength ( 29691431) High myopia ( 32428537) Myopia ( 27182965) Pancreatic beta-cell glucose sensitivity ( 32944759) Refractive error ( 20835236 23396134 32231278) RR interval (heart rate) ( 20031603) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Systolic blood pressure ( 30224653) Venous thromboembolism ( 33592630)
Interacting Genes		20 interacting genes: CEBPA EHD4 GRIN2B GRK2 HRAS NTRK1 NTRK2 NTRK3 PRKACA RAC1 RHOA RRAS2 SNRNP70 SRC SRPK2 STIP1 TNK2 USP8 YWHAB YWHAE	67 interacting genes: ADARB1 APP ARSF BACE2 CASP3 CBS CDC42 CDKL3 CEBPA CEP63 CFAP298 CHERP CRP CTDP1 DDX17 DYRK1A FTCD GATD3 GEMIN2 GTPBP2 HNRNPA2B1 HTATSF1 HUNK IL32 IL7R ITSN1 LRP1 MYC NUDT21 OGT PDE9A PIGP PRKD2 PRMT5 PRPF40A PRPF6 PSMG1 RASGRF1 RBM11 RELA RIPPLY3 RNF11 RSPH1 RUNX1 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SPATC1L SRPK1 SRRM4 SRSF1 SRSF10 SRSF2 SUMO3 TIAM1 USP25 USP7 WBP4 ZRANB2
Entrez ID		5923	6625
HPRD ID		07362	01617
Ensembl ID		ENSG00000058335	ENSG00000104852
Uniprot IDs		A8K270 Q13972 Q8IUU5	P08621 Q9UFS1
PDB IDs			2L5I 2L5J 3CW1 3PGW 4PJO 4PKD 6QX9 7B0Y 7VPX 8R08
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Nucleotide Binding Neurotrophin Receptor Activity Neurotrophin Binding Regulation Of Cell Junction Assembly Cellular Response To Growth Factor Stimulus Signal Transduction Protein Kinase Activity Response To Growth Factor Intracellular Signal Transduction Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Kinase Activity Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Small GTPase-mediated Signal Transduction Neuron Migration Regulation Of Synapse Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Signal Transduction Phosphorylation Mechanoreceptor Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Migration Neurotrophin Signaling Pathway Protein Domain Specific Binding Focal Adhesion Positive Regulation Of Cell Junction Assembly Plasma Membrane Regulation Of Blood Circulation Regulation Of Neuron Apoptotic Process Perinuclear Region Of Cytoplasm Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ATP Binding Phosphoprotein Binding Cell Motility Endosome Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Cell Communication	SMAD Protein Complex MRNA Processing Heteromeric SMAD Protein Complex RNA Metabolic Process RNA Processing RNA Splicing Nucleoplasm MRNA Metabolic Process Nucleic Acid Metabolic Process I-SMAD Binding Regulation Of MRNA Splicing, Via Spliceosome SMAD Protein Signal Transduction RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleus Regulation Of MRNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Response To Growth Factor Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Positive Regulation Of Developmental Process Identical Protein Binding Embryonic Pattern Specification Intracellular Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Primary MiRNA Processing Cardiac Conduction System Development Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Regulation Of MiRNA Transcription Spliceosomal SnRNP Assembly Nuclear Speck Positive Regulation Of Cell Differentiation Spliceosomal Complex Assembly Protein-containing Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of Gene Expression DEAD/H-box RNA Helicase Binding RNA Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process
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