RASGRF1 and TNK2

Number of citations of the paper that reports this interaction (PubMedID 10882715)
0

Data Source:
HPRD (in vitro)

		RASGRF1	TNK2
Description		Ras protein specific guanine nucleotide releasing factor 1	tyrosine kinase non receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Growth Cone Neuron Projection	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Adherens Junction Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Anchoring Junction Grb2-EGFR Complex Cytoophidium
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Glutamate Receptor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity GTPase Inhibitor Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding WW Domain Binding Protein Serine Kinase Activity
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Long-term Memory Neuron Projection Development Response To Endoplasmic Reticulum Stress Positive Regulation Of Rac Protein Signal Transduction Intracellular Signal Transduction Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Type B Pancreatic Cell Proliferation Regulation Of Ras Protein Signal Transduction Positive Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity	Endocytosis Signal Transduction Cell Surface Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Clathrin-dependent Endocytosis
Pathways		Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade	Signaling by LTK
Drugs			ATP Debromohymenialdisine Entrectinib Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Bronchopulmonary dysplasia ( 23897914) Hand grip strength ( 29691431) High myopia ( 32428537) Myopia ( 27182965) Pancreatic beta-cell glucose sensitivity ( 32944759) Refractive error ( 20835236 23396134 32231278) RR interval (heart rate) ( 20031603) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Asthma ( 31959851) Bronchopulmonary dysplasia ( 23897914) Low density lipoprotein cholesterol levels ( 30498476) Total cholesterol levels ( 30498476)
Interacting Genes		20 interacting genes: CEBPA EHD4 GRIN2B GRK2 HRAS NTRK1 NTRK2 NTRK3 PRKACA RAC1 RHOA RRAS2 SNRNP70 SRC SRPK2 STIP1 TNK2 USP8 YWHAB YWHAE	52 interacting genes: AKT1 AQP1 AR ARSL ATP5F1A BAG3 CDC42 CLTC CSPG4 CTTN CYSRT1 DPH2 EGFR FGFR1 FYN GALT GRB2 HCK HECW1 HSH2D HSP90AB2P ITFG2 KCNA5 KRTAP10-3 MAGI3 MCF2 MERTK NCK1 NEK6 NOTCH2NLA NPHP1 PDGFRB PIK3R1 PIK3R3 RASGEF1C RASGRF1 RPL18A SEZ6 SH2D1A SH2D1B SIAH1 SMURF1 SNX9 SOCS4 SRC SRSF5 UBC VTI1B WAS WWOX WWP2 YES1
Entrez ID		5923	10188
HPRD ID		07362	06104
Ensembl ID		ENSG00000058335	ENSG00000061938
Uniprot IDs		A8K270 Q13972 Q8IUU5	A0A499FJ16 A0A5F9ZGX5 A0A5F9ZHJ2 A0A5F9ZHP4 A0A5F9ZI29 B3KXJ4 C9J1X3 Q07912
PDB IDs			1CF4 1U46 1U4D 1U54 3EQP 3EQR 4EWH 4HZR 4HZS 4ID7 5ZXB 6VQM 7KP6 8FE9 8FZ3 8HMT 8Q5P 8THA
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Nucleotide Binding Neurotrophin Receptor Activity Neurotrophin Binding Regulation Of Cell Junction Assembly Cellular Response To Growth Factor Stimulus Signal Transduction Protein Kinase Activity Response To Growth Factor Intracellular Signal Transduction Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Kinase Activity Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Small GTPase-mediated Signal Transduction Neuron Migration Regulation Of Synapse Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Signal Transduction Phosphorylation Mechanoreceptor Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Migration Neurotrophin Signaling Pathway Protein Domain Specific Binding Focal Adhesion Positive Regulation Of Cell Junction Assembly Plasma Membrane Regulation Of Blood Circulation Regulation Of Neuron Apoptotic Process Perinuclear Region Of Cytoplasm Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ATP Binding Phosphoprotein Binding Cell Motility Endosome Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Cell Communication	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytosol Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Cell-cell Junction Ephrin Receptor Binding Signal Transduction Cell Migration Cell Motility Regulation Of Cell Projection Organization Intracellular Signal Transduction Regulation Of Signal Transduction Leukocyte Activation Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization T Cell Costimulation Actin Filament Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Actin Filament Polymerization Regulation Of Plasma Membrane Bounded Cell Projection Organization Peptidyl-tyrosine Phosphorylation Cell Activation Regulation Of Apoptotic Process Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization To Membrane Regulation Of Programmed Cell Death Regulation Of Actin Cytoskeleton Organization Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Lymphocyte Activation Negative Regulation Of Apoptotic Process Regulation Of Actin Filament Organization Positive Regulation Of Locomotion Regulation Of Protein Localization To Plasma Membrane Plasma Membrane Protein Autophosphorylation Cell Differentiation Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Biological Quality Protein Kinase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Locomotion
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