RASGRF1 and EHD4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RASGRF1	EHD4
Gene Name		Ras protein-specific guanine nucleotide-releasing factor 1	EH-domain containing 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Growth Cone Neuron Projection	Nucleus Endoplasmic Reticulum Plasma Membrane Membrane Early Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Glutamate Receptor Binding	Nucleic Acid Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Synaptic Transmission Long-term Memory Cell Proliferation Neuron Projection Development Positive Regulation Of Ras GTPase Activity Activation Of Rac GTPase Activity Regulation Of Rac Protein Signal Transduction Regulation Of Ras Protein Signal Transduction Positive Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity	Pinocytosis Regulation Of Endocytosis Endocytic Recycling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Homooligomerization Cellular Response To Growth Factor Stimulus
Pathways		Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses Post NMDA receptor activation events Ras activation uopn Ca2+ infux through NMDA receptor
Drugs
Diseases
GWAS		Refractive error ( 23396134 20835236) RR interval (heart rate) ( 20031603)
Protein-Protein Interactions		16 interactors: ADRBK1 CEBPA EHD4 HRAS NTRK1 NTRK2 NTRK3 PRKACA RAC1 RHOA RRAS2 SNRNP70 TNK2 USP8 YWHAB YWHAE	2 interactors: AFP RASGRF1
Entrez ID		5923	30844
HPRD ID		07362	10435
Ensembl ID		ENSG00000058335	ENSG00000103966
Uniprot IDs		A8K270 F8VPA5 J3KQP9 Q13972 Q8IUU5	A8K9B9 Q9H223
PDB IDs
Enriched GO Terms of Interacting Partners?		Neurotrophin Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Locomotion Positive Regulation Of Protein Modification Process Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Response To Organic Substance Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Ras Protein Signal Transduction Regulation Of Phosphorus Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Projection Organization Positive Regulation Of Protein Metabolic Process Cell Migration Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Cell Motility Signal Transduction Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Response To Stress Mechanoreceptor Differentiation Signaling Regulation Of Cell Death Positive Regulation Of Organelle Organization Cell Communication Protein Autophosphorylation Positive Regulation Of MAPK Cascade Regulation Of Catalytic Activity Regulation Of Cell Projection Organization Positive Regulation Of Kinase Activity Positive Regulation Of Cell Differentiation Activation Of Protein Kinase Activity Defense Response	Ovulation From Ovarian Follicle Activation Of Rac GTPase Activity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Ovulation Progesterone Metabolic Process C21-steroid Hormone Metabolic Process Regulation Of Rac Protein Signal Transduction Activation Of Rho GTPase Activity Long-term Memory Activation Of Ras GTPase Activity Positive Regulation Of Ras Protein Signal Transduction SMAD Protein Signal Transduction Positive Regulation Of Rac GTPase Activity Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Small GTPase Mediated Signal Transduction Cellular Ketone Metabolic Process Ovulation Cycle Process Female Gonad Development Female Gamete Generation Ovulation Cycle Development Of Primary Female Sexual Characteristics Regulation Of Receptor Activity Memory
Tagcloud ?		abundantly ampa arbor branch branches branching clamp corroborated dendritic div dominated dramatically electrophysiological heteromers miniature nmdars nr1nr2a nr1nr2b nr2 nr2a nr2b opportunity patch recordings refinement synapses tri ventral vscns
Tagcloud (Difference) ?		abundantly ampa arbor branch branches branching clamp corroborated dendritic div dominated dramatically electrophysiological heteromers miniature nmdars nr1nr2a nr1nr2b nr2 nr2a nr2b opportunity patch recordings refinement synapses tri ventral vscns
Tagcloud (Intersection) ?