RASGRF1 and EHD4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RASGRF1	EHD4
Description		Ras protein specific guanine nucleotide releasing factor 1	EH domain containing 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Growth Cone Neuron Projection	Nucleus Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Plasma Membrane Adherens Junction Membrane Endocytic Vesicle Early Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Anchoring Junction
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Glutamate Receptor Binding	Nucleotide Binding Nucleic Acid Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding Protein-macromolecule Adaptor Activity Cadherin Binding Metal Ion Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Long-term Memory Neuron Projection Development Response To Endoplasmic Reticulum Stress Positive Regulation Of Rac Protein Signal Transduction Intracellular Signal Transduction Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Type B Pancreatic Cell Proliferation Regulation Of Ras Protein Signal Transduction Positive Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity	Cell Migration Involved In Sprouting Angiogenesis Endocytosis Pinocytosis Regulation Of Endocytosis Endocytic Recycling Protein Homooligomerization Cilium Assembly Cellular Response To Growth Factor Stimulus Protein Localization To Plasma Membrane
Pathways		Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Adult body size ( 32376654) Bronchopulmonary dysplasia ( 23897914) Hand grip strength ( 29691431) High myopia ( 32428537) Myopia ( 27182965) Pancreatic beta-cell glucose sensitivity ( 32944759) Refractive error ( 20835236 23396134 32231278) RR interval (heart rate) ( 20031603) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Adverse response to drug ( 30420678) Granulocyte count ( 27863252) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte count ( 29403010 27863252 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		20 interacting genes: CEBPA EHD4 GRIN2B GRK2 HRAS NTRK1 NTRK2 NTRK3 PRKACA RAC1 RHOA RRAS2 SNRNP70 SRC SRPK2 STIP1 TNK2 USP8 YWHAB YWHAE	4 interacting genes: AFP CDC42 RASGRF1 SUMO2
Entrez ID		5923	30844
HPRD ID		07362	10435
Ensembl ID		ENSG00000058335	ENSG00000103966
Uniprot IDs		A8K270 Q13972 Q8IUU5	A8K9B9 Q9H223
PDB IDs
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Nucleotide Binding Neurotrophin Receptor Activity Neurotrophin Binding Regulation Of Cell Junction Assembly Cellular Response To Growth Factor Stimulus Signal Transduction Protein Kinase Activity Response To Growth Factor Intracellular Signal Transduction Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Kinase Activity Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Small GTPase-mediated Signal Transduction Neuron Migration Regulation Of Synapse Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Signal Transduction Phosphorylation Mechanoreceptor Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Migration Neurotrophin Signaling Pathway Protein Domain Specific Binding Focal Adhesion Positive Regulation Of Cell Junction Assembly Plasma Membrane Regulation Of Blood Circulation Regulation Of Neuron Apoptotic Process Perinuclear Region Of Cytoplasm Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ATP Binding Phosphoprotein Binding Cell Motility Endosome Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Cell Communication	Progesterone Metabolic Process Sexual Reproduction Ovulation From Ovarian Follicle Small Molecule Binding Ovulation Leading Edge Membrane Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Thioesterase Binding Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Neuron Projection Development Positive Regulation Of Pinocytosis Dendritic Cell Migration Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Golgi Localization Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Heart Contraction Endothelin Receptor Signaling Pathway Involved In Heart Process Cardiac Conduction System Development Embryonic Heart Tube Development Positive Regulation Of MAPK Cascade Small GTPase-mediated Signal Transduction Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Dendritic Spine Morphogenesis Establishment Of Golgi Localization Neuron Projection Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Neuropilin Signaling Pathway Postsynapse GBD Domain Binding Golgi Transport Complex Storage Vacuole Cell Migration Involved In Heart Development Polarized Epithelial Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Glutamate Receptor Binding Positive Regulation Of Rac Protein Signal Transduction Type B Pancreatic Cell Proliferation Positive Regulation Of Ras Protein Signal Transduction SUMO Transferase Activity Protein Tag Activity C21-steroid Hormone Metabolic Process Positive Regulation Of Lamellipodium Assembly
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?