TBCA and AFF1

Data Source: HiPPIP (Novel)

		TBCA	AFF1
Name		tubulin folding cofactor A	ALF transcription elongation factor 1
Structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton	Nucleus Transcription Elongation Factor Complex Super Elongation Complex
	Molecular Function	RNA Binding Protein Binding Tubulin Binding Beta-tubulin Binding Protein-folding Chaperone Binding	Protein Binding
	Biological Process	Protein Folding Tubulin Complex Assembly Post-chaperonin Tubulin Folding Pathway	Regulation Of Gene Expression
Pathways		Post-chaperonin tubulin folding pathway	None
Diseases		None	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Appendicular lean mass ( 33097823 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Mean platelet volume ( 27863252 32888494 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 )	Alzheimer's disease (cognitive decline) ( 23535033 ) Apolipoprotein A1 levels ( 32203549 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 32888494 27863252 ) Bulimia nervosa ( 23568457 ) Diastolic blood pressure ( 28234671 ) Eyebrow thickness ( 26926045 ) HDL cholesterol levels ( 30698716 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Heel bone mineral density ( 28869591 30598549 ) Hematocrit ( 27863252 32888494 29403010 ) Hematological and biochemical traits ( 31902109 ) Hemoglobin ( 32888494 29403010 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Lipoprotein (a) levels ( 33730874 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 27863252 29403010 ) Mean corpuscular volume ( 32888494 27863252 29403010 ) Mean platelet volume ( 27863252 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (thyroid preparations) ( 31015401 ) Metabolic syndrome ( 31589552 ) Multiple sclerosis ( 31604244 ) PR interval ( 32439900 ) Red blood cell count ( 32888494 27863252 ) Refractive error ( 32231278 ) Systemic lupus erythematosus ( 22291604 ) Total bilirubin levels ( 29403010 ) Triglyceride levels ( 32154731 30698716 32203549 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 30275531 20686565 20864672 25961943 ) White blood cell count (basophil) ( 27863252 29403010 )
Novel Interactors		7 novel interactors: AFF1 CNTN4 EDIL3 LHFPL2 PAM PHAX RAG1	1 novel interactors: TBCA
Interacting Genes		5 interacting genes: CDC42 CEBPA ERBB3 TAF9 TERF2IP	9 interacting genes: ARFIP1 H3-4 MLLT1 MLLT3 NT5E SASH1 SIAH1 SIAH2 SMAD9
Entrez ID		6902	4299
HPRD ID		18166	08871
Ensembl ID		ENSG00000171530	ENSG00000172493
Uniprot IDs		E5RIX8 O75347 Q6FGD7	B4DJU9 P51825 Q14C88
PDB IDs		1H7C	2LM0
GO Terms Enriched among Interactors		None	Transcription Elongation Factor Complex Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding