TBCA and EDIL3

Data Source: HiPPIP (Novel)

		TBCA	EDIL3
Name		tubulin folding cofactor A	EGF like and discoidin domains 3
Structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Extracellular Vesicle
	Molecular Function	RNA Binding Protein Binding Tubulin Binding Beta-tubulin Binding Protein-folding Chaperone Binding	Integrin Binding Extracellular Matrix Structural Constituent Calcium Ion Binding Metal Ion Binding
	Biological Process	Protein Folding Tubulin Complex Assembly Post-chaperonin Tubulin Folding Pathway	Cell Adhesion Positive Regulation Of Cell-substrate Adhesion
Pathways		Post-chaperonin tubulin folding pathway	Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
GWAS		Appendicular lean mass ( 33097823 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Mean platelet volume ( 27863252 32888494 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 )	Alzheimer's disease biomarkers ( 23419831 ) Ankylosing spondylitis ( 22138694 ) Anxiety and stress-related disorders ( 31116379 ) Asthma and hay fever ( 24388013 ) Blood trace element (Cu levels) ( 23720494 ) Chemerin levels ( 20237162 ) Loneliness ( 27629369 ) Mitochondrial DNA levels ( 25240745 ) Photic sneeze reflex ( 27182965 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Uterine fibroid size (maximum dimension) ( 30196971 )
Novel Interactors		7 novel interactors: AFF1 CNTN4 EDIL3 LHFPL2 PAM PHAX RAG1	3 novel interactors: MEF2C NPHP4 TBCA
Interacting Genes		5 interacting genes: CDC42 CEBPA ERBB3 TAF9 TERF2IP	4 interacting genes: ADARB1 ITGAV RBM11 RSPH1
Entrez ID		6902	10085
HPRD ID		18166	09350
Ensembl ID		ENSG00000171530	ENSG00000164176
Uniprot IDs		E5RIX8 O75347 Q6FGD7	O43854
PDB IDs		1H7C	4D90
GO Terms Enriched among Interactors		None	Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Double-stranded RNA Adenosine Deaminase Activity Hypoglossal Nerve Morphogenesis Adenosine To Inosine Editing Spinal Cord Ventral Commissure Morphogenesis Facial Nerve Morphogenesis Entry Into Host Cell By A Symbiont-containing Vacuole Apolipoprotein A-I-mediated Signaling Pathway Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Blood Vessel Development C-X3-C Chemokine Binding Alphav-beta3 Integrin-PKCalpha Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Lipoprotein Metabolic Process Integrin Alphav-beta1 Complex Integrin Alphav-beta6 Complex Opsonin Binding Neuregulin Binding Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Integrin Alphav-beta8 Complex Extracellular Matrix Protein Binding Positive Regulation Of Macrophage Apoptotic Process Primary Heart Field Specification Muscle Cell Fate Determination Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Glomerulus Morphogenesis Regulation Of Synaptic Activity Nephron Tubule Epithelial Cell Differentiation Cellular Response To Trichostatin A Sinoatrial Valve Morphogenesis AMPA Selective Glutamate Receptor Signaling Pathway Radial Spoke Head 1 Radial Spoke Head 3 Radial Spoke Head Ribbon Synapse Photoreceptor Distal Connecting Cilium TRNA-specific Adenosine Deaminase Activity NMDA Selective Glutamate Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Protein Localization To Ciliary Transition Zone Adenosine Deaminase Activity Regulation Of Entry Of Bacterium Into Host Cell Transforming Growth Factor Beta Production Positive Regulation Of Behavioral Fear Response Post-chaperonin Tubulin Folding Pathway Outer Dense Fiber Deaminase Activity Positive Regulation Of Fear Response