RABGGTA and BMPR2

Number of citations of the paper that reports this interaction (PMID 15188402)
20

Data Source:
HPRD (in vitro)

		RABGGTA	BMPR2
Gene Name		Rab geranylgeranyltransferase, alpha subunit	bone morphogenetic protein receptor, type II (serine/threonine kinase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Rab-protein Geranylgeranyltransferase Complex	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Basal Plasma Membrane Cell Surface Apical Plasma Membrane Dendrite Neuronal Cell Body Spanning Component Of Plasma Membrane
	Molecular Function	Rab Geranylgeranyltransferase Activity Zinc Ion Binding Rab GTPase Binding	Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Metal Ion Binding
	Biological Process	Cellular Protein Modification Process Visual Perception Protein Geranylgeranylation	Mesoderm Formation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Transcription From RNA Polymerase II Promoter Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Brain Development Cellular Response To Starvation Anterior/posterior Pattern Specification Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Lung Blood Pressure Signal Transduction By Phosphorylation Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Vasoconstriction Vascular Endothelial Growth Factor Receptor Signaling Pathway Lung Alveolus Development Positive Regulation Of Axon Extension Involved In Axon Guidance Limb Development Endochondral Bone Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of DNA Biosynthetic Process
Pathways			Signaling by BMP
Drugs
Diseases
GWAS			Urate levels ( 23263486)
Protein-Protein Interactions		2 interactors: BMPR2 RAB1A	49 interactors: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CCDC89 CES1 CRYAB CTBP1 DYNLT1 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HNRNPR LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RABGGTA SULT1E1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1
Entrez ID		5875	659
HPRD ID		03547	02880
Ensembl ID		ENSG00000100949	ENSG00000204217
Uniprot IDs		D3DS70 Q92696	Q13873
PDB IDs			2HLQ 3G2F
Enriched GO Terms of Interacting Partners?		Cellular Response To Starvation Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Regulation Of Lung Blood Pressure Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Vasoconstriction Interleukin-8 Production Response To Nutrient Levels Response To Extracellular Stimulus Positive Regulation Of Axon Extension Involved In Axon Guidance Lymphatic Endothelial Cell Differentiation Cargo Loading Into Vesicle Growth Hormone Secretion Lymphangiogenesis Lymph Vessel Morphogenesis Positive Regulation Of Glycoprotein Metabolic Process Regulation Of Axon Extension Involved In Axon Guidance Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye COPII-coated Vesicle Budding Lymph Vessel Development Negative Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of DNA Biosynthetic Process Virion Assembly Activin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Cytokine Secretion Chondrocyte Development Vesicle Transport Along Microtubule Melanosome Transport Pigment Granule Transport Positive Regulation Of BMP Signaling Pathway Establishment Of Melanosome Localization Positive Regulation Of Axon Extension Positive Regulation Of Bone Mineralization Localization Within Membrane Melanosome Localization Autophagic Vacuole Assembly Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cartilage Development Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Blood Vessel Remodeling Regulation Of DNA Biosynthetic Process Negative Regulation Of Blood Pressure Cellular Response To Stress Lung Alveolus Development	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Ossification Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Cell Development Regulation Of Bone Mineralization Regulation Of MAPK Cascade Regulation Of Osteoblast Differentiation Regulation Of Phosphorylation Regulation Of Cell Differentiation Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Phosphorus Metabolic Process Growth Signal Transduction By Phosphorylation Regulation Of Signal Transduction Cartilage Development Regulation Of Ossification Positive Regulation Of Cell Differentiation Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cartilage Development Regulation Of Growth Cell Surface Receptor Signaling Pathway Connective Tissue Development Positive Regulation Of Cartilage Development Phosphate-containing Compound Metabolic Process Peptidyl-threonine Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Response To Stimulus
Tagcloud ?			apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Difference) ?			apoptotic autophagy bmprs bmps chondrosarcoma chondrosarcomas clinicopathological crucial dedifferentiated eventually find g2 inconsistent interfering mdm2 morphogenetic multifunctional predict prevalent promoted protective repression sensitized silencing somewhat tumorigenesis tumorigenicity xiap
Tagcloud (Intersection) ?