MYRIP and MYO7A

Number of citations of the paper that reports this interaction (PubMedID 11964381)
23

Data Source:
HPRD (in vitro)

		MYRIP	MYO7A
Description		myosin VIIA and Rab interacting protein	myosin VIIA
Image		No pdb structure
GO Annotations	Cellular Component	Exocyst Photoreceptor Outer Segment Cytoplasm Cytosol Actin Cytoskeleton Transport Vesicle Cortical Actin Cytoskeleton Dense Core Granule Cytoplasmic Vesicle Melanosome Synapse Perinuclear Region Of Cytoplasm	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Lysosomal Membrane Cytosol Cytoskeleton Microvillus Cell Cortex Actin Cytoskeleton Membrane Apical Plasma Membrane Myosin Complex Myosin VII Complex Photoreceptor Connecting Cilium Stereocilium Melanosome Synapse Photoreceptor Cell Cilium Stereocilium Base Upper Tip-link Density
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Myosin Binding Small GTPase Binding Metal Ion Binding Protein Kinase A Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Spectrin Binding Identical Protein Binding ADP Binding Protein-containing Complex Binding Actin Filament Binding
	Biological Process	Intracellular Protein Transport Positive Regulation Of Insulin Secretion	Phagolysosome Assembly Intracellular Protein Transport Endocytosis Phagocytosis Actin Filament Organization Lysosome Organization Sensory Organ Development Sensory Perception Visual Perception Sensory Perception Of Sound Intracellular Protein Localization Cell Projection Organization Actin Filament-based Movement Eye Photoreceptor Cell Development Inner Ear Morphogenesis Mechanoreceptor Differentiation Inner Ear Auditory Receptor Cell Differentiation Neuron Development Inner Ear Development Sensory Perception Of Light Stimulus Equilibrioception Pigment Granule Localization Pigment Granule Transport Auditory Receptor Cell Stereocilium Organization Inner Ear Receptor Cell Differentiation Inner Ear Receptor Cell Stereocilium Organization Cochlea Development Sensory Organ Morphogenesis
Pathways		Insulin processing Regulation of MITF-M-dependent genes involved in pigmentation	The canonical retinoid cycle in rods (twilight vision) Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases			Deafness, autosomal recessive Usher syndrome (US) Deafness, autosomal dominant
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Information processing speed ( 21130836) Rapid automised naming of letters ( 30741946) Sleep-related phenotypes ( 17903308) Whole brain grey matter density ( 31530798)	Lewy body disease ( 25188341) Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)
Interacting Genes		6 interacting genes: C1orf216 MYO7A OIP5 RAB27A RAB27B VPS26C	12 interacting genes: ACTA1 CALM1 CDH23 KEAP1 KHDRBS1 LINC00839 MAP2 MYRIP PRKAR1A USH1C VEZT WHRN
Entrez ID		25924	4647
HPRD ID		14796	02043
Ensembl ID		ENSG00000170011	ENSG00000137474
Uniprot IDs		Q8NFW9	Q13402
PDB IDs			5MV9
Enriched GO Terms of Interacting Partners?		Melanosome Pigment Granule Localization Protein Domain Specific Binding Pigment Granule Transport Multivesicular Body Membrane Exocytic Vesicle Myosin V Binding Multivesicular Body Sorting Pathway Apical Plasma Membrane Vesicle-mediated Transport Upper Tip-link Density Protein Transport Myosin VII Complex Photoreceptor Outer Segment GDP Binding Positive Regulation Of Exocytosis Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway G Protein Activity Establishment Of Protein Localization Intracellular Protein Transport Establishment Of Vesicle Localization Secretory Granule Vesicle Localization Establishment Of Localization In Cell Complement-dependent Cytotoxicity Pericentric Heterochromatin Organization CENP-A Recruiting Complex Late Endosome Phagolysosome Assembly Stereocilium Base Intracellular Protein Localization Exosomal Secretion Endosome Equilibrioception Regulation Of Exocytosis Weibel-Palade Body Exocytosis Platelet Dense Granule Membrane Natural Killer Cell Degranulation Photoreceptor Cell Cilium Anterograde Axonal Protein Transport Establishment Of Organelle Localization CENP-A Containing Chromatin Assembly Chromocenter Positive Regulation Of Secretion By Cell Protein Transport Along Microtubule Vesicle Organization GTPase Activity Positive Regulation Of Secretion	Stereocilia Ankle Link Complex Stereocilium Tip Inner Ear Receptor Cell Differentiation Myosin Binding Mechanoreceptor Differentiation Inner Ear Receptor Cell Stereocilium Organization Stereocilium Equilibrioception Cell Cycle Phase Transition G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Photoreceptor Inner Segment Actin Filament Auditory Receptor Cell Stereocilium Organization Inner Ear Auditory Receptor Cell Differentiation Hair Cell Differentiation Mitotic Cell Cycle Phase Transition Sensory Perception Of Mechanical Stimulus Sensory Perception Of Sound Cytosol Neuron Projection Development Photoreceptor Cell Maintenance Sensory Perception Of Light Stimulus Synapse Apical Distal Dendrite Pyruvate Carboxylase Activity Grb2-Sos Complex Sarcomere Negative Regulation Of High Voltage-gated Calcium Channel Activity Centrosome Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cilium Dendritic Filopodium Positive Regulation Of Anterograde Synaptic Vesicle Transport Distal Dendrite Positive Regulation Of Anterograde Dense Core Granule Transport Primary Dendrite Viral RNA Genome Packaging Protein Localization To Microvillus Inner Ear Morphogenesis Photoreceptor Outer Segment Cerebellar Purkinje Cell Layer Formation Paranodal Junction Maintenance Cochlear Hair Cell Ribbon Synapse Cell Cycle G1/S Phase Transition Cell Projection Proximal Neuron Projection Dendritic Branch Positive Regulation Of Insulin Secretion Stereocilia Ankle Link
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