MYRIP and RAB27B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MYRIP	RAB27B
Description		myosin VIIA and Rab interacting protein	RAB27B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Exocyst Photoreceptor Outer Segment Cytoplasm Cytosol Actin Cytoskeleton Transport Vesicle Cortical Actin Cytoskeleton Dense Core Granule Cytoplasmic Vesicle Melanosome Synapse Perinuclear Region Of Cytoplasm	Endosome Late Endosome Golgi Apparatus Golgi Stack Plasma Membrane Membrane Apical Plasma Membrane Trans-Golgi Network Transport Vesicle Secretory Granule Synaptic Vesicle Membrane Platelet Dense Granule Membrane Multivesicular Body Membrane Melanosome Zymogen Granule Membrane Extracellular Exosome Exocytic Vesicle Axon Cytoplasm
	Molecular Function	Actin Binding Protein Binding Zinc Ion Binding Myosin Binding Small GTPase Binding Metal Ion Binding Protein Kinase A Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding
	Biological Process	Intracellular Protein Transport Positive Regulation Of Insulin Secretion	Exocytosis Regulation Of Exocytosis Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Multivesicular Body Sorting Pathway Anterograde Axonal Protein Transport
Pathways		Insulin processing Regulation of MITF-M-dependent genes involved in pigmentation	Platelet degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 23007406) Information processing speed ( 21130836) Rapid automised naming of letters ( 30741946) Sleep-related phenotypes ( 17903308) Whole brain grey matter density ( 31530798)	Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Depression ( 29700475) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		6 interacting genes: C1orf216 MYO7A OIP5 RAB27A RAB27B VPS26C	10 interacting genes: DHPS GORASP2 MLPH MYRIP RPH3A RPH3AL SYTL1 SYTL2 SYTL4 UNC13D
Entrez ID		25924	5874
HPRD ID		14796	04846
Ensembl ID		ENSG00000170011	ENSG00000041353
Uniprot IDs		Q8NFW9	O00194
PDB IDs			2F7S
Enriched GO Terms of Interacting Partners?		Melanosome Pigment Granule Localization Protein Domain Specific Binding Pigment Granule Transport Multivesicular Body Membrane Exocytic Vesicle Myosin V Binding Multivesicular Body Sorting Pathway Apical Plasma Membrane Vesicle-mediated Transport Upper Tip-link Density Protein Transport Myosin VII Complex Photoreceptor Outer Segment GDP Binding Positive Regulation Of Exocytosis Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway G Protein Activity Establishment Of Protein Localization Intracellular Protein Transport Establishment Of Vesicle Localization Secretory Granule Vesicle Localization Establishment Of Localization In Cell Complement-dependent Cytotoxicity Pericentric Heterochromatin Organization CENP-A Recruiting Complex Late Endosome Phagolysosome Assembly Stereocilium Base Intracellular Protein Localization Exosomal Secretion Endosome Equilibrioception Regulation Of Exocytosis Weibel-Palade Body Exocytosis Platelet Dense Granule Membrane Natural Killer Cell Degranulation Photoreceptor Cell Cilium Anterograde Axonal Protein Transport Establishment Of Organelle Localization CENP-A Containing Chromatin Assembly Chromocenter Positive Regulation Of Secretion By Cell Protein Transport Along Microtubule Vesicle Organization GTPase Activity Positive Regulation Of Secretion	Small GTPase Binding Exocytic Vesicle Neurexin Family Protein Binding Intracellular Protein Transport Positive Regulation Of Exocytosis Exocytosis Secretion By Cell Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Positive Regulation Of Regulated Secretory Pathway Establishment Of Protein Localization Regulation Of Exocytosis Calcium-dependent Activation Of Synaptic Vesicle Fusion Cellular Localization Protein Transport Establishment Of Localization In Cell Intracellular Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Melanosome Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Regulation Of Regulated Secretory Pathway Myosin Binding Regulation Of Secretion Positive Regulation Of Protein Secretion Regulation Of Vesicle Fusion Regulation Of Insulin Secretion Regulation Of Calcium Ion-dependent Exocytosis Deoxyhypusine Synthase Activity Forebrain Generation Of Neurons Regulation Of Peptide Hormone Secretion Positive Regulation Of Transport Transport Vesicle Membrane Intracellular Protein Localization Cytoplasmic Vesicle Cortical Actin Cytoskeleton Spermidine Catabolic Process Positive Regulation Of Protein Transport Granuloma Formation Regulation Of Vesicle-mediated Transport Zinc Ion Binding Regulation Of Hormone Secretion Regulation Of Protein Secretion Phosphatidylinositol-4,5-bisphosphate Binding Regulation Of Timing Of Neuron Differentiation Polyamine Catabolic Process Amygdala Development Structural Constituent Of Tooth Enamel
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