HNRNPA2B1 and MIRLET7D

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		HNRNPA2B1	MIRLET7D
Description		heterogeneous nuclear ribonucleoprotein A2/B1	microRNA let-7d
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Extracellular Region Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cajal Body Membrane Nuclear Matrix Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Extracellular Space RISC Complex Extracellular Vesicle
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding Identical Protein Binding Single-stranded Telomeric DNA Binding DNA Polymerase Binding G-rich Strand Telomeric DNA Binding Molecular Condensate Scaffold Activity N6-methyladenosine-containing RNA Reader Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus RNA Splicing Primary MiRNA Processing DNA Geometric Change RNA Transport MRNA Transport Regulation Of Macromolecule Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening MiRNA Transport	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Copper Artenimol
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		105 interacting genes: ARID4B CDKN2A CEBPA CRNDE CSNK2A1 CSNK2B ENY2 ERG ESR1 FBXO11 H3-4 HIPK3 HNRNPL LIG4 LINC00963 LINC01232 MAP4K2 MCPH1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEIL3 NR4A1 OGT RNF10 SNRNP70 SREK1 STAT5B SUMO2 TRAPPC12 TRIM35 TTF2 VHL WEE2-AS1 YAE1 ZMYM2	100 interacting genes: AIMP1 APOBEC3B AQR ATXN2L C1QBP CDC5L CHERP CPSF6 DARS1 DDX1 DDX21 DDX3X DDX3Y DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PLOD1 PRMT1 PTBP1 PUF60 PUM1 PURA QARS1 RARS1 RBM10 RBM12B RBM14 RBM4 RBM4B RBM5 RBM6 RTCB SAFB SART3 SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SLTM SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		3181	406886
HPRD ID		02526
Ensembl ID		ENSG00000122566	ENSG00000199133
Uniprot IDs		A0A7I2V4N1 P22626
PDB IDs		1X4B 5EN1 5HO4 5WWE 5WWF 5WWG 6WPQ 6WQK 7WM3 8DU2 8DUW 8EC7 8HNI
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Negative Regulation Of Cell Migration MRNA Destabilization Regulation Of Macromolecule Biosynthetic Process RNA Destabilization Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Negative Regulation Of Developmental Process Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Angiogenesis Negative Regulation Of Multicellular Organismal Process Regulation Of Vasculature Development Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Stability Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of RNA Stability Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signaling	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process RNA Splicing MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Macromolecule Metabolic Process Nucleus Post-transcriptional Regulation Of Gene Expression Nucleoplasm MiRNA Binding Spliceosomal Complex Regulation Of MRNA Processing Ribonucleoprotein Complex Aminoacyl-tRNA Synthetase Multienzyme Complex Catalytic Step 2 Spliceosome Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Translation Cytoplasmic Stress Granule Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Stability Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Stability Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of Translation TRNA Aminoacylation Nucleolus Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cytoplasmic Translation Positive Regulation Of Gene Expression
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