HNRNPA2B1 and FBXO11

Number of citations of the paper that reports this interaction (PubMedID 37837399)
46

Data Source:
BioGRID (pull down)

		HNRNPA2B1	FBXO11
Description		heterogeneous nuclear ribonucleoprotein A2/B1	F-box protein 11
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Extracellular Region Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cajal Body Membrane Nuclear Matrix Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding MiRNA Binding Identical Protein Binding Single-stranded Telomeric DNA Binding DNA Polymerase Binding G-rich Strand Telomeric DNA Binding Molecular Condensate Scaffold Activity N6-methyladenosine-containing RNA Reader Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein-arginine N-methyltransferase Activity Metal Ion Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing MRNA Export From Nucleus RNA Splicing Primary MiRNA Processing DNA Geometric Change RNA Transport MRNA Transport Regulation Of Macromolecule Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening MiRNA Transport	Epithelial To Mesenchymal Transition Ubiquitin-dependent Protein Catabolic Process Sensory Perception Of Sound Negative Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Copper Artenimol
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Asthma ( 27611488) Chronotype ( 30696823) Cortical surface area ( 32963231) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Macular thickness ( 30535121) PR interval ( 32439900) Refractive error ( 32231278) Schizophrenia ( 23894747)
Interacting Genes		105 interacting genes: ARID4B CDKN2A CEBPA CRNDE CSNK2A1 CSNK2B ENY2 ERG ESR1 FBXO11 H3-4 HIPK3 HNRNPL LIG4 LINC00963 LINC01232 MAP4K2 MCPH1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEIL3 NR4A1 OGT RNF10 SNRNP70 SREK1 STAT5B SUMO2 TRAPPC12 TRIM35 TTF2 VHL WEE2-AS1 YAE1 ZMYM2	8 interacting genes: BAHD1 BCL6 CFTR DSCR9 HDAC6 HNRNPA2B1 TP53 USP16
Entrez ID		3181	80204
HPRD ID		02526	06985
Ensembl ID		ENSG00000122566	ENSG00000138081
Uniprot IDs		A0A7I2V4N1 P22626	A0A804HK63 Q86XK2
PDB IDs		1X4B 5EN1 5HO4 5WWE 5WWF 5WWG 6WPQ 6WQK 7WM3 8DU2 8DUW 8EC7 8HNI	5VMD
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Negative Regulation Of Cell Migration MRNA Destabilization Regulation Of Macromolecule Biosynthetic Process RNA Destabilization Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Negative Regulation Of Developmental Process Regulation Of Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Angiogenesis Negative Regulation Of Multicellular Organismal Process Regulation Of Vasculature Development Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Stability Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of RNA Stability Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signaling	Chromatin Remodeling Epigenetic Regulation Of Gene Expression Chromatin Organization Negative Regulation Of Cell Growth Negative Regulation Of DNA Replication Negative Regulation Of Gene Expression, Epigenetic Replication Fork 14-3-3 Protein Binding Negative Regulation Of Growth Negative Regulation Of Macroautophagy Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cellular Senescence Regulation Of Lymphocyte Apoptotic Process Cellular Response To Stress Transcription Corepressor Binding Negative Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Cell Development Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Molecular Condensate Scaffold Activity Regulation Of Mitophagy Negative Regulation Of Helicase Activity Regulation Of Autophagy Of Mitochondrion Negative Regulation Of G1 To G0 Transition Mitophagy Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Ribosome Biogenesis T Cell Activation Involved In Immune Response Autophagy Of Mitochondrion Regulation Of DNA Metabolic Process Negative Regulation Of Isotype Switching To IgE Isotypes Lymphocyte Activation Involved In Immune Response Negative Regulation Of Gene Expression Regulation Of Mitotic Cell Cycle DNA Replication Regulation Of DNA Replication Negative Regulation Of Mast Cell Cytokine Production Isotype Switching To IgE Isotypes Mononuclear Cell Proliferation Regulation Of Cell Growth Chromatin Binding Lymphocyte Proliferation Negative Regulation Of Plasma Cell Differentiation Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein-folding Chaperone Binding Enzyme Binding Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport
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