OSTC and CCR9

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		OSTC	CCR9
Description		oligosaccharyltransferase complex non-catalytic subunit	C-C motif chemokine receptor 9
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Oligosaccharyltransferase Complex A	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding Protein-macromolecule Adaptor Activity	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemotaxis Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Asparagine N-linked glycosylation Maturation of spike protein Regulation of CDH1 posttranslational processing and trafficking to plasma membrane PD-L1(CD274) glycosylation and translocation to plasma membrane	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs			Vercirnon
Diseases
GWAS			Celiac disease ( 20190752) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Interacting Genes		6 interacting genes: ATP13A2 CCR9 EDA F2RL1 GPR35 TRARG1	19 interacting genes: ADGRG1 AIG1 CCL25 CD81 DGAT1 G6PC3 HLA-A KDELR1 NEU1 OSTC RHBDD2 SAP130 SCAMP4 SPNS1 TMC6 TRPM4 TSPAN7 TTYH1 YWHAE
Entrez ID		58505	10803
HPRD ID		13120	09200
Ensembl ID		ENSG00000198856	ENSG00000173585
Uniprot IDs		A0A087WUD3 Q9NRP0	B2R734 P51686
PDB IDs		6S7O 8B6L 8PN9	5LWE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytosolic Calcium Ion Concentration Chemokine Receptor Activity Cytokine-mediated Signaling Pathway Trachea Gland Development Proteinase-activated Receptor Activity Positive Regulation Of Exocytosis Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium G Protein-coupled Receptor Activity Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Protein Localization Positive Regulation Of Renin Secretion Into Blood Stream Chemokine-mediated Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Polyamine Transmembrane Transporter Activity Organelle Membrane Fusion Spermine Transport Extracellular Exosome Biogenesis Vesicle Fusion P-type Transmembrane Transporter Activity Spermine Transmembrane Transport Organelle Fusion ABC-type Polyamine Transporter Activity Box C/D Sno(s)RNA 3'-end Processing U6 2'-O-snRNA Methylation Death Receptor Agonist Activity Positive Regulation Of Protein Secretion Positive Regulation Of Killing Of Cells Of Another Organism Extracellular Vesicle Biogenesis P-type Ion Transporter Activity Regulation Of Autophagosome Size Membrane Fusion Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP Regulation Of Protein Localization To Nucleus Hair Follicle Placode Formation Salivary Gland Cavitation Mature Conventional Dendritic Cell Differentiation Thrombin-activated Receptor Activity Negative Regulation Of Lysosomal Protein Catabolic Process Cupric Ion Binding Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Regulation Of Exocytosis SnRNA Modification Glucose Import In Response To Insulin Stimulus Positive Regulation Of Toll-like Receptor 2 Signaling Pathway	Regulation Of T Cell Cytokine Production Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of T Cell Mediated Immunity
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