PRUNE and NME1

Number of citations of the paper that reports this interaction (PMID 11687967)
13

Data Source:
HPRD (in vivo, in vitro)

		PRUNE	NME1
Gene Name		prune exopolyphosphatase	NME/NM23 nucleoside diphosphate kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Focal Adhesion	Nucleus Cytoplasm Mitochondrion Cytosol Membrane Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Inorganic Diphosphatase Activity Protein Binding Metal Ion Binding	Magnesium Ion Binding Deoxyribonuclease Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding Ribosomal Small Subunit Binding Poly(A) RNA Binding
	Biological Process	Metabolic Process	Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Endocytosis Nervous System Development Negative Regulation Of Cell Proliferation Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Small Molecule Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Nucleobase-containing Small Molecule Metabolic Process
Pathways			Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		1 interactors: NME1	27 interactors: APEX1 AURKA CCND3 FXR2 GORASP2 ITGB1 KSR1 MIF NIF3L1 NME2 NME3 NME4 PID1 POLR1C PRUNE RAC1 RORA RORB RRAD SET SMARCD1 SOX30 SREK1IP1 TERF1 TIAM1 TNPO2 WDYHV1
Entrez ID		58497	4830
HPRD ID		15188	01131
Ensembl ID		ENSG00000143363	ENSG00000239672
Uniprot IDs		Q86TP1	P15531
PDB IDs			1JXV 1UCN 2HVD 2HVE 3L7U 4ENO
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Small Molecule Interconversion GTP Biosynthetic Process UTP Biosynthetic Process GTP Metabolic Process UTP Metabolic Process CTP Biosynthetic Process Nucleoside Diphosphate Phosphorylation Positive Regulation Of DNA Binding Pyrimidine Ribonucleotide Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Pyrimidine Nucleoside Metabolic Process Pyrimidine Nucleotide Metabolic Process Nucleoside Triphosphate Biosynthetic Process Regulation Of DNA Binding Positive Regulation Of Binding DNA Catabolic Process Positive Regulation Of Epithelial Cell Proliferation Purine Nucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Purine Nucleoside Metabolic Process Regulation Of Binding Regulation Of Epithelial Cell Proliferation Ribonucleotide Metabolic Process Nucleoside Metabolic Process Nucleotide Biosynthetic Process Purine Nucleotide Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Ribose Phosphate Metabolic Process Aromatic Compound Catabolic Process Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Endocytosis Negative Regulation Of Cell Proliferation	Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process GTP Biosynthetic Process UTP Biosynthetic Process GTP Metabolic Process UTP Metabolic Process Regulation Of Cell Death CTP Biosynthetic Process Positive Regulation Of Metabolic Process Nucleoside Diphosphate Phosphorylation Pyrimidine Ribonucleotide Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Regulation Of Metabolic Process Response To Organic Cyclic Compound Pyrimidine Nucleoside Metabolic Process Regulation Of Cell Cycle Response To Hormone Pyrimidine Nucleotide Metabolic Process Cellular Response To Lipid Nucleoside Triphosphate Biosynthetic Process Nucleosome Disassembly Mitotic Cell Cycle Nucleobase-containing Small Molecule Interconversion Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Development Response To Drug Positive Regulation Of Cell Projection Organization Response To Organic Substance Positive Regulation Of Cell Cycle Response To Lipid Ribonucleotide Metabolic Process Positive Regulation Of Mitotic Cell Cycle Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Regulation Of DNA Replication Regulation Of Macrophage Activation Regulation Of Protein Metabolic Process Cell Cycle Telomere Maintenance Via Telomere Lengthening Cellular Response To Organic Substance Purine Nucleotide Biosynthetic Process Cell-matrix Adhesion Ribose Phosphate Biosynthetic Process Cellular Response To Organic Cyclic Compound Regulation Of Cellular Component Organization Cellular Response To Acid Chemical
Tagcloud ?		abdome accompanying ampicillin anomalies anorectal belly centre cotrimoxazole cystourethrography enterococci fahd grown hydronephrosis hypospadias ivu khobar king klebsiella observational parenchymal plain pneumoniae predominant prominent proven tertiary thereapeutic voiding xrays	17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme2 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3
Tagcloud (Difference) ?		abdome accompanying ampicillin anomalies anorectal belly centre cotrimoxazole cystourethrography enterococci fahd grown hydronephrosis hypospadias ivu khobar king klebsiella observational parenchymal plain pneumoniae predominant prominent proven tertiary thereapeutic voiding xrays	17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme2 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3
Tagcloud (Intersection) ?