SRPRB and RCHY1

Number of citations of the paper that reports this interaction (PubMedID 18344599)
0

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		SRPRB	RCHY1
Description		SRP receptor subunit beta	ring finger and CHY zinc finger domain containing 1
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Signal Recognition Particle Receptor Complex Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Membrane	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Nucleotide Binding Protein Binding GTP Binding	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Protein Targeting To ER	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Error-free Translesion Synthesis Rescue Of Stalled Ribosome
Pathways		SRP-dependent cotranslational protein targeting to membrane XBP1(S) activates chaperone genes	Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Nicotine dependence symptom count ( 25555482) Red blood cell count ( 32888494)	Metabolite levels ( 23823483) Response to tocilizumab in rheumatoid arthritis ( 22491018)
Interacting Genes		3 interacting genes: CDK5RAP3 RCHY1 UBC	74 interacting genes: ADAMTSL4 AIG1 ANGPTL8 AOX1 AR ARF4 ATN1 AXIN1 BIRC3 CAMK2A CAMK2G CDK9 CDKN1B CHD8 CHEK2 COPE COX6C CREB5 CYBA DAPK1 DCUN1D5 F7 FADS6 GFI1B GORAB HOXA1 HOXA2 HOXA3 HOXB1 HOXB2 HOXB5 HOXC11 HOXC4 HOXD10 HRG KAT5 KLHL41 KRTAP9-2 LIMS2 MEOX2 MSH3 MT2A NKD2 NLK NOTCH2NLA PGLS PLAGL2 PMM1 PRDX4 RAB11A RBM38 RILP RPN2 SEMA4C SERPINA1 SERPINA5 SERTAD1 SRPRB TAOK2 TMBIM1 TMEM14C TMEM184A TP53 TP63 TP73 TRIM8 UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 WDR74 ZNF160
Entrez ID		58477	25898
HPRD ID		18105	07607
Ensembl ID		ENSG00000144867	ENSG00000163743
Uniprot IDs		Q549N5 Q9Y5M8	Q96PM5
PDB IDs		7NFX	2JRJ 2K2C 2K2D 7YNX
Enriched GO Terms of Interacting Partners?		Rescue Of Stalled Ribosome Ribosome Disassembly Protein Modification By Small Protein Conjugation Translational Elongation Organelle Disassembly Post-translational Protein Modification Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Regulation Of Post-translational Protein Modification Positive Regulation Of Reticulophagy Definitive Erythrocyte Differentiation Regulation Of Reticulophagy Protein Modification Process Error-free Translesion Synthesis Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Apoptotic Nuclear Changes Positive Regulation Of Protein Modification Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Protein Ufmylation Regulation Of Phosphatase Activity MDM2/MDM4 Family Protein Binding Protein Tag Activity Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Protein Ubiquitination Mitogen-activated Protein Kinase Binding Regulation Of Protein Modification Process Regulation Of Dephosphorylation Translesion Synthesis Proteolysis Involved In Protein Catabolic Process Ubiquitin-like Protein Ligase Binding Protein Metabolic Process DNA Damage Response Postreplication Repair NF-kappaB Binding Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Mitotic G2 DNA Damage Checkpoint Signaling Cyclin Binding Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Metabolic Process DNA Synthesis Involved In DNA Repair	DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Embryonic Skeletal System Morphogenesis Regionalization Anterior/posterior Pattern Specification Skeletal System Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Embryonic Organ Morphogenesis Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Signal Transduction By P53 Class Mediator Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Embryonic Morphogenesis Chromatin Positive Regulation Of Biosynthetic Process Rhombomere Development Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Localization To Plasma Membrane P53 Binding MDM2/MDM4 Family Protein Binding Skeletal System Development Regulation Of Macromolecule Biosynthetic Process Rhombomere 4 Development Developmental Process Nucleus Nucleoplasm Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Rhombomere 3 Development Regulation Of Protein Localization To Cell Periphery Animal Organ Morphogenesis
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