SRPRB and CDK5RAP3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		SRPRB	CDK5RAP3
Gene Name		signal recognition particle receptor, B subunit	CDK5 regulatory subunit associated protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Membrane Integral Component Of Membrane	Cytoplasm Endomembrane System Membrane Protein Complex
	Molecular Function	GTP Binding	Protein Binding Protein Kinase Binding
	Biological Process	Translation SRP-dependent Cotranslational Protein Targeting To Membrane Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Small GTPase Mediated Signal Transduction Gene Expression Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Brain Development Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Ufmylation
Pathways		IRE1alpha activates chaperones Translation SRP-dependent cotranslational protein targeting to membrane XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994)	Epilepsy (generalized) ( 22949513)
Protein-Protein Interactions		2 interactors: CDK5RAP3 RCHY1	11 interactors: CDK5R1 CREBBP CRMP1 DGCR14 DISC1 FKBP6 KPNA2 SRPRB TAB1 TAX1BP3 TSPYL4
Entrez ID		58477	80279
HPRD ID		18105	12190
Ensembl ID		ENSG00000144867	ENSG00000108465
Uniprot IDs		Q549N5 Q9Y5M8	B7Z6N4 F5H3I5 Q96JB5
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Ufmylation Protein Modification By Small Protein Conjugation	Cerebral Cortex Radially Oriented Cell Migration Positive Regulation Of Protein Modification Process Cerebral Cortex Cell Migration Superior Olivary Nucleus Maturation Telencephalon Cell Migration Forebrain Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Pons Maturation N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Serine Phosphorylation Of STAT3 Protein Cerebral Cortex Development Germ-line Stem Cell Maintenance Serine Phosphorylation Of STAT Protein Neuron Migration Signal Transduction Pyrimidine Nucleobase Catabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Protein Localization To Cell Surface Activation Of MAPKKK Activity Pallium Development Regulation Of Protein Kinase Activity
Tagcloud ?		15k cdnas characters clustering developmentally dncic2 dosage ds eef1g eif3sf extra hchr21 hierarchical manifested mrpl10 mrps18a neurogenesis neuron neuropathological outgrowth patterned peg3 phenotypic retardation sf3a60 snapc3 syngr2 tt2f ubce8	anchors aspartate ataxin atx1 autonomous bergmann cerebellum collectively consistently downregulated eventually glia glutamate helix interacting knockin maxer mediates mediating mutant named purkinje represses repression rescues sca1 strengthened transporter vulnerability
Tagcloud (Difference) ?		15k cdnas characters clustering developmentally dncic2 dosage ds eef1g eif3sf extra hchr21 hierarchical manifested mrpl10 mrps18a neurogenesis neuron neuropathological outgrowth patterned peg3 phenotypic retardation sf3a60 snapc3 syngr2 tt2f ubce8	anchors aspartate ataxin atx1 autonomous bergmann cerebellum collectively consistently downregulated eventually glia glutamate helix interacting knockin maxer mediates mediating mutant named purkinje represses repression rescues sca1 strengthened transporter vulnerability
Tagcloud (Intersection) ?