PVRL2 and DUS2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PVRL2	DUS2
Gene Name		poliovirus receptor-related 2 (herpesvirus entry mediator B)	dihydrouridine synthase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome	Cytoplasm Mitochondrion Endoplasmic Reticulum
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding	Double-stranded RNA Binding Protein Kinase Inhibitor Activity Protein Binding TRNA Dihydrouridine Synthase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Spermatid Development Spermatid Nucleus Differentiation Fertilization Response To Virus Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cell Part Morphogenesis Positive Regulation Of Mast Cell Activation Cell Junction Assembly Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Cell-cell Junction Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Coreceptor-mediated Virion Attachment To Host Cell Regulation Of Immune Response Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity	TRNA Dihydrouridine Synthesis Negative Regulation Of Protein Kinase Activity Oxidation-reduction Process Negative Regulation Of Cell Death
Pathways		Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Alzheimer's disease ( 18823527 22159054) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease (late onset) ( 20885792 23565137) Alzheimer's disease biomarkers ( 23419831) HDL cholesterol ( 21909109) Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		20 interactors: ATP5J2 CD226 DUS2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP5-9 LYRM4 MAPK6 MDFI MLLT4 NOTCH2NL PICK1 PVRL3 PVRL4 SIAH1 TIGIT TNFRSF12A USP53	4 interactors: EPRS PVRL2 SMN1 TK1
Entrez ID		5819	54920
HPRD ID		02879	08624
Ensembl ID		ENSG00000130202	ENSG00000167264
Uniprot IDs		Q92692	B4DKP8 E7EUN9 Q9NX74
PDB IDs		3R0N 4DFH 4DFI 4HZA
Enriched GO Terms of Interacting Partners?		Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization	Cellular Component Assembly Coreceptor-mediated Virion Attachment To Host Cell Fetal Process Involved In Parturition Prolyl-tRNA Aminoacylation Susceptibility To T Cell Mediated Cytotoxicity Sperm Mitochondrion Organization Skeletal Muscle Cell Proliferation Fusion Of Virus Membrane With Host Plasma Membrane Glutamyl-tRNA Aminoacylation Susceptibility To Natural Killer Cell Mediated Cytotoxicity Thymidine Metabolic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Cortisol Virion Attachment To Host Cell Deoxyribonucleoside Monophosphate Biosynthetic Process Positive Regulation Of Immune Response To Tumor Cell Adhesion Of Symbiont To Host Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage NcRNA Metabolic Process Positive Regulation Of Mast Cell Activation Acrosome Assembly Establishment Of Mitochondrion Localization Parturition Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Response To Copper Ion Regulation Of Natural Killer Cell Mediated Immunity Spermatid Nucleus Differentiation Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Mast Cell Activation Mitochondrion Localization Pyrimidine Nucleobase Metabolic Process Secretory Granule Organization Multicellular Organismal Reproductive Process Viral Entry Into Host Cell Spliceosomal SnRNP Assembly Multicellular Organism Reproduction Entry Into Host Cell Pyrimidine Nucleoside Biosynthetic Process Spliceosomal Complex Assembly Protein Complex Assembly Reproduction Protein Homotetramerization Pyrimidine Nucleoside Metabolic Process Single Organism Reproductive Process Positive Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Translation Adherens Junction Organization
Tagcloud ?		adarb2 asymptomatic carriers carrying ceacam6 cntnap2 col19a1 commonest consider def4 dopaminergic draxin fcer2 functionally g2019s hbg1 idiopathic initiating lrrk2 merit ncapg2 never parkinson pd seq slc2a14 snca tcl1b variations
Tagcloud (Difference) ?		adarb2 asymptomatic carriers carrying ceacam6 cntnap2 col19a1 commonest consider def4 dopaminergic draxin fcer2 functionally g2019s hbg1 idiopathic initiating lrrk2 merit ncapg2 never parkinson pd seq slc2a14 snca tcl1b variations
Tagcloud (Intersection) ?