NECTIN2 and KRTAP12-2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NECTIN2	KRTAP12-2
Description		nectin cell adhesion molecule 2	keratin associated protein 12-2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Membrane Apical Junction Complex Cell-cell Contact Zone Extracellular Exosome	Cytosol Intermediate Filament
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Receptor Ligand Activity Cell Adhesion Molecule Binding	Protein Binding
	Biological Process	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Spermatid Development Spermatid Nucleus Differentiation Fertilization Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cellular Anatomical Entity Morphogenesis Positive Regulation Of Mast Cell Activation Natural Killer Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Viral Entry Into Host Cell Symbiont Entry Into Host Cell Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of T Cell Receptor Signaling Pathway Establishment Of Localization In Cell Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization	Keratinization
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 30498476) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Urate levels ( 31578528)
Interacting Genes		38 interacting genes: AFDN ATP5MF CD226 CYSRT1 DUS2 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP5-9 LCE1C LCE1E LCE1F LCE2B LCE2C LCE5A LYRM4 MAPK6 MDFI MEOX2 NBPF19 NECTIN3 NECTIN4 NOTCH2NLA NR4A3 P4HB PICK1 RGS20 SIAH1 TCF4 TGM1 TIGIT USP53	127 interacting genes: ADAM12 ARID5A ATN1 ATP6V1C2 AVPI1 BCL6B BEX2 CATSPER1 CBLL2 CBX2 CCNL1 CCNL2 CFP CHRD CNNM3 CYSRT1 DGCR6 DHRS1 EFEMP2 ETNK2 FAM27E3 FHL3 FOXD4 FOXD4L1 FOXD4L3 GDF15 GPANK1 GPRIN2 GREM1 HOXA1 HOXB9 HSFX1 HSFX2 HYPK INO80B IQUB KRT34 KRTAP10-5 KRTAP10-8 KRTAP12-1 KRTAP12-4 KRTAP13-2 KRTAP15-1 KRTAP19-2 KRTAP21-2 KRTAP26-1 KRTAP3-2 KRTAP4-2 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1F LCE2A LCE2B LCE4A LCE5A LINC00671 MEOX2 MGAT5B MYOZ1 MYPOP NBPF19 NECTIN2 NOTCH2NLA NPDC1 NR1D2 ODF1 OTX1 PACSIN3 PATZ1 PCSK5 PDE9A PELO PHLDA1 PIH1D2 PLAC8 POLR1C POM121L8P POU4F2 RAD23A RBM39 RBPMS RBX1 RHOXF2 SEMA3B SLC12A4 SLC13A5 SLC15A2 SLC15A3 SPATA3 SPMIP9 SPRED2 SPRY1 SRSF8 TCEA2 TINAGL1 TLE5 TMEM179B TNS2 TRIM42 TRIP13 TSGA10IP TTPA VASN VENTX VGLL3 YIPF3 YY1 ZBTB9 ZDHHC1 ZIM2 ZNF100 ZNF408 ZNF497 ZNF581 ZNF587 ZNF624 ZNF688 ZNF696 ZNF764 ZNF785 ZNHIT1
Entrez ID		5819	353323
HPRD ID		02879	11198
Ensembl ID		ENSG00000130202	ENSG00000221864
Uniprot IDs		Q92692	P59991
PDB IDs		3R0N 4DFH 4DFI 4HZA 5V52 8X6B
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Intermediate Filament Keratinization Epidermis Development Keratin Filament Cell Adhesion Mediator Activity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Tissue Development Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Adhesion Molecule Binding Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Regulation Of Leukocyte Mediated Cytotoxicity Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Mast Cell Activation Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Natural Killer Cell Mediated Immunity Leukocyte Mediated Cytotoxicity Positive Regulation Of Immune Response To Tumor Cell Regulation Of Mast Cell Activation Adherens Junction Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Innate Immune Response Cell-cell Contact Zone Cochlea Morphogenesis Semicircular Canal Formation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Neuron Apoptotic Process Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway TRNA-dihydrouridine20 Synthase Activity L-cysteine Desulfurase Complex Symbiont Entry Into Host Cell Lymphocyte Mediated Immunity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules	Intermediate Filament Keratinization Keratin Filament Epidermis Development Protein Binding Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Sequence-specific DNA Binding Tissue Development Regulation Of Nucleobase-containing Compound Metabolic Process Peptidoglycan Transport Identical Protein Binding Peptide:proton Symporter Activity Dipeptide Transmembrane Transporter Activity Negative Regulation Of Lens Fiber Cell Differentiation Dipeptide Transmembrane Transport Dipeptide Import Across Plasma Membrane Dipeptide Transport
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