PVRL2 and USP53

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PVRL2	USP53
Gene Name		poliovirus receptor-related 2 (herpesvirus entry mediator B)	ubiquitin specific peptidase 53
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome	Cellular_component
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Spermatid Development Spermatid Nucleus Differentiation Fertilization Response To Virus Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cell Part Morphogenesis Positive Regulation Of Mast Cell Activation Cell Junction Assembly Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Cell-cell Junction Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Coreceptor-mediated Virion Attachment To Host Cell Regulation Of Immune Response Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity	Ubiquitin-dependent Protein Catabolic Process Biological_process
Pathways		Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Alzheimer's disease ( 18823527 22159054) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease (late onset) ( 20885792 23565137) Alzheimer's disease biomarkers ( 23419831) HDL cholesterol ( 21909109) Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		20 interactors: ATP5J2 CD226 DUS2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP5-9 LYRM4 MAPK6 MDFI MLLT4 NOTCH2NL PICK1 PVRL3 PVRL4 SIAH1 TIGIT TNFRSF12A USP53	5 interactors: DAB1 GRB2 IREB2 PVRL2 TRAF2
Entrez ID		5819	54532
HPRD ID		02879	11669
Ensembl ID		ENSG00000130202	ENSG00000145390
Uniprot IDs		Q92692	Q70EK8 Q9H9I0
PDB IDs		3R0N 4DFH 4DFI 4HZA
Enriched GO Terms of Interacting Partners?		Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization	Positive Regulation Of Cell Activation Regulation Of Cell Activation Regulation Of Cell Adhesion Positive Regulation Of Immune Response Positive Regulation Of T Cell Mediated Immunity Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Coreceptor-mediated Virion Attachment To Host Cell Protein Heterooligomerization Positive Regulation Of Adaptive Immune Response Susceptibility To T Cell Mediated Cytotoxicity Sperm Mitochondrion Organization Cerebellum Structural Organization Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Lateral Motor Column Neuron Migration Fusion Of Virus Membrane With Host Plasma Membrane Regulation Of Adaptive Immune Response Positive Regulation Of T Cell Activation Spinal Cord Motor Neuron Migration Positive Regulation Of Homotypic Cell-cell Adhesion Radial Glia Guided Migration Of Purkinje Cell Response To Iron(II) Ion Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Cell Projection Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Glial Cell Apoptotic Process Locomotion Regulation Of T Cell Activation Regulation Of Immune System Process Regulation Of Phosphorylation Virion Attachment To Host Cell Positive Regulation Of Immune Response To Tumor Cell Protoporphyrinogen IX Biosynthetic Process Cellular Response To Stimulus Aging Adhesion Of Symbiont To Host Cell Differentiation Positive Regulation Of Protein Homodimerization Activity Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Phosphorus Metabolic Process Cellular Response To Nitric Oxide Protoporphyrinogen IX Metabolic Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cellular Response To Stress
Tagcloud ?		adarb2 asymptomatic carriers carrying ceacam6 cntnap2 col19a1 commonest consider def4 dopaminergic draxin fcer2 functionally g2019s hbg1 idiopathic initiating lrrk2 merit ncapg2 never parkinson pd seq slc2a14 snca tcl1b variations
Tagcloud (Difference) ?		adarb2 asymptomatic carriers carrying ceacam6 cntnap2 col19a1 commonest consider def4 dopaminergic draxin fcer2 functionally g2019s hbg1 idiopathic initiating lrrk2 merit ncapg2 never parkinson pd seq slc2a14 snca tcl1b variations
Tagcloud (Intersection) ?