PVRL2 and LYRM4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PVRL2	LYRM4
Gene Name		poliovirus receptor-related 2 (herpesvirus entry mediator B)	LYR motif containing 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome	Nucleus Mitochondrial Matrix
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Spermatid Development Spermatid Nucleus Differentiation Fertilization Response To Virus Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cell Part Morphogenesis Positive Regulation Of Mast Cell Activation Cell Junction Assembly Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Cell-cell Junction Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Coreceptor-mediated Virion Attachment To Host Cell Regulation Of Immune Response Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity	Small Molecule Metabolic Process
Pathways		Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Mitochondrial iron-sulfur cluster biogenesis
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Alzheimer's disease ( 18823527 22159054) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease (late onset) ( 20885792 23565137) Alzheimer's disease biomarkers ( 23419831) HDL cholesterol ( 21909109) Waist-to-hip circumference ratio (interaction) ( 23192594)	Height ( 21998595)
Protein-Protein Interactions		20 interactors: ATP5J2 CD226 DUS2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP5-9 LYRM4 MAPK6 MDFI MLLT4 NOTCH2NL PICK1 PVRL3 PVRL4 SIAH1 TIGIT TNFRSF12A USP53	1 interactors: PVRL2
Entrez ID		5819	57128
HPRD ID		02879	12855
Ensembl ID		ENSG00000130202	ENSG00000214113
Uniprot IDs		Q92692	C9JRX8 C9JY28 F5H189 Q9HD34
PDB IDs		3R0N 4DFH 4DFI 4HZA
Enriched GO Terms of Interacting Partners?		Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization	Coreceptor-mediated Virion Attachment To Host Cell Sperm Mitochondrion Organization Susceptibility To T Cell Mediated Cytotoxicity Fusion Of Virus Membrane With Host Plasma Membrane Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Virion Attachment To Host Cell Positive Regulation Of Immune Response To Tumor Cell Adhesion Of Symbiont To Host Positive Regulation Of Mast Cell Activation Acrosome Assembly Establishment Of Mitochondrion Localization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Spermatid Nucleus Differentiation Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Mast Cell Activation Mitochondrion Localization Secretory Granule Organization Viral Entry Into Host Cell Entry Into Host Cell Positive Regulation Of T Cell Mediated Cytotoxicity Adherens Junction Organization Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Interaction With Host Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Nucleus Organization Membrane Fusion Spermatid Development Spermatid Differentiation Positive Regulation Of Adaptive Immune Response Fertilization Positive Regulation Of Innate Immune Response Viral Life Cycle Regulation Of Adaptive Immune Response Cilium Organization Cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Vesicle Organization Cell-cell Junction Organization Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Regulation Of Innate Immune Response Germ Cell Development Response To Virus
Tagcloud ?		adarb2 asymptomatic carriers carrying ceacam6 cntnap2 col19a1 commonest consider def4 dopaminergic draxin fcer2 functionally g2019s hbg1 idiopathic initiating lrrk2 merit ncapg2 never parkinson pd seq slc2a14 snca tcl1b variations	1q32 await biologic bowel cd cdkal1 colitis collectively corrected crohn define discovered ecm1 formal genotyped help implicating kilobase loci replicated rs11205387 scans shared strongest susceptibility tagging threshold uc ulcerative
Tagcloud (Difference) ?		adarb2 asymptomatic carriers carrying ceacam6 cntnap2 col19a1 commonest consider def4 dopaminergic draxin fcer2 functionally g2019s hbg1 idiopathic initiating lrrk2 merit ncapg2 never parkinson pd seq slc2a14 snca tcl1b variations	1q32 await biologic bowel cd cdkal1 colitis collectively corrected crohn define discovered ecm1 formal genotyped help implicating kilobase loci replicated rs11205387 scans shared strongest susceptibility tagging threshold uc ulcerative
Tagcloud (Intersection) ?