PVRL2 and PVRL4

Number of citations of the paper that reports this interaction (PMID 21982860)
4

Data Source:
BioGRID (pull down)

		PVRL2	PVRL4
Gene Name		poliovirus receptor-related 2 (herpesvirus entry mediator B)	poliovirus receptor-related 4
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome	Plasma Membrane Adherens Junction Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding	Protein Binding
	Biological Process	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Spermatid Development Spermatid Nucleus Differentiation Fertilization Response To Virus Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cell Part Morphogenesis Positive Regulation Of Mast Cell Activation Cell Junction Assembly Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Cell-cell Junction Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Coreceptor-mediated Virion Attachment To Host Cell Regulation Of Immune Response Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity	Cell Adhesion Viral Process Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization
Pathways		Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Alzheimer's disease ( 18823527 22159054) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease (late onset) ( 20885792 23565137) Alzheimer's disease biomarkers ( 23419831) HDL cholesterol ( 21909109) Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		20 interactors: ATP5J2 CD226 DUS2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP5-9 LYRM4 MAPK6 MDFI MLLT4 NOTCH2NL PICK1 PVRL3 PVRL4 SIAH1 TIGIT TNFRSF12A USP53	5 interactors: MLLT4 PICK1 PVRL1 PVRL2 TIGIT
Entrez ID		5819	81607
HPRD ID		02879	17934
Ensembl ID		ENSG00000130202	ENSG00000143217
Uniprot IDs		Q92692	K4PZ75 Q96NY8
PDB IDs		3R0N 4DFH 4DFI 4HZA	4FRW 4GJT 4JJH
Enriched GO Terms of Interacting Partners?		Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization	Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Viral Entry Into Host Cell Entry Into Host Cell Cell Development Interaction With Host Coreceptor-mediated Virion Attachment To Host Cell Susceptibility To T Cell Mediated Cytotoxicity Sperm Mitochondrion Organization Fusion Of Virus Membrane With Host Plasma Membrane Viral Life Cycle Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Projection Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Virus Cell Adhesion Establishment Of Endothelial Intestinal Barrier Enamel Mineralization Virion Attachment To Host Cell DNA Methylation Involved In Embryo Development Positive Regulation Of Immune Response To Tumor Cell Dendritic Spine Maintenance Adhesion Of Symbiont To Host Cell Differentiation Tooth Mineralization Neuronal Ion Channel Clustering Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Desmosome Organization Positive Regulation Of Mast Cell Activation Negative Regulation Of Actin Nucleation Acrosome Assembly Amelogenesis Establishment Of Mitochondrion Localization Positive Regulation Of Rap GTPase Activity Long Term Synaptic Depression Regulation Of Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Response To External Stimulus Positive Regulation Of Receptor Internalization Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Component Assembly Negative Regulation Of Interleukin-12 Production Dendritic Spine Organization Regulation Of Rap GTPase Activity DNA Methylation Involved In Gamete Generation
Tagcloud ?		adarb2 asymptomatic carriers carrying ceacam6 cntnap2 col19a1 commonest consider def4 dopaminergic draxin fcer2 functionally g2019s hbg1 idiopathic initiating lrrk2 merit ncapg2 never parkinson pd seq slc2a14 snca tcl1b variations
Tagcloud (Difference) ?		adarb2 asymptomatic carriers carrying ceacam6 cntnap2 col19a1 commonest consider def4 dopaminergic draxin fcer2 functionally g2019s hbg1 idiopathic initiating lrrk2 merit ncapg2 never parkinson pd seq slc2a14 snca tcl1b variations
Tagcloud (Intersection) ?