PVRL3 and PARD3

Number of citations of the paper that reports this interaction (PMID 12515806)
36

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		PVRL3	PARD3
Gene Name		poliovirus receptor-related 3	par-3 family cell polarity regulator
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell-cell Adherens Junction Integral Component Of Membrane Apical Junction Complex Postsynaptic Membrane	Spindle Cytosol Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Tight Junction Cell Cortex Endomembrane System Cell Junction Internode Region Of Axon Neuronal Cell Body Protein Complex Axonal Growth Cone Apical Part Of Cell
	Molecular Function	Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Fertilization Single Organismal Cell-cell Adhesion Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Retina Morphogenesis In Camera-type Eye	Microtubule Cytoskeleton Organization Apical Constriction Protein Complex Assembly Protein Targeting To Membrane Cell Cycle Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Axonogenesis Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Positive Regulation Of Myelination Regulation Of Actin Filament-based Process Cell Junction Assembly Wound Healing, Spreading Of Cells Cell-cell Junction Organization Centrosome Localization Regulation Of Cellular Localization Tight Junction Assembly Establishment Of Epithelial Cell Polarity
Pathways		Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions	Loss of Function of TGFBR2 in Cancer Cell junction organization TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Tight junction interactions Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Cell-cell junction organization Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 19684603) Emphysema-related traits ( 20709820) Major depressive disorder ( 21621269) Schizophrenia ( 21682944)
Protein-Protein Interactions		13 interactors: KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 MLLT4 NOTCH2NL PARD3 PVR PVRL1 PVRL2 RGS20 TIGIT	27 interactors: CDC42 DYNLL1 F11R INADL INSC LIMK2 PARD6A PARD6B PARD6G PLCB1 PLCB3 PNMA1 PRKCG PRKCI PVRL1 PVRL3 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 YWHAB YWHAG YWHAH YWHAZ
Entrez ID		25945	56288
HPRD ID		08454	05994
Ensembl ID			ENSG00000148498
Uniprot IDs		Q9NQS3	Q8TEW0
PDB IDs		4FOM	2KOM
Enriched GO Terms of Interacting Partners?		Cell Junction Assembly Cell-cell Junction Organization Adherens Junction Organization Susceptibility To T Cell Mediated Cytotoxicity Viral Entry Into Host Cell Entry Into Host Cell Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immune Response To Tumor Cell Interaction With Host Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Viral Life Cycle Response To Virus Cellular Component Assembly Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of T Cell Mediated Cytotoxicity Cell Adhesion Regulation Of T Cell Mediated Cytotoxicity Locomotion Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Regulation Of Leukocyte Mediated Cytotoxicity Viral Process Sperm Mitochondrion Organization Fusion Of Virus Membrane With Host Plasma Membrane Positive Regulation Of Adaptive Immune Response Response To Other Organism Response To Biotic Stimulus Positive Regulation Of Innate Immune Response Regulation Of Adaptive Immune Response Cell Development Apical Constriction Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Epithelial Cell Development Establishment Of Endothelial Intestinal Barrier Asymmetric Cell Division Cell Differentiation Cell Part Morphogenesis Enamel Mineralization Virion Attachment To Host Cell Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Regulation Of Innate Immune Response Adhesion Of Symbiont To Host Positive Regulation Of Myelination Tooth Mineralization	Cell-cell Junction Organization Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell Junction Assembly Cellular Response To Growth Factor Stimulus Cellular Component Assembly Tight Junction Assembly Positive Regulation Of Apoptotic Process Response To Growth Factor Regulation Of Cellular Component Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Apical Junction Assembly Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Signal Transduction Cellular Response To Organic Substance Regulation Of Cell Death Positive Regulation Of Transport Cell-cell Junction Assembly Signaling Positive Regulation Of Mitochondrion Organization Cell Communication Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Development Regulation Of Intracellular Transport Regulation Of Apoptotic Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation System Development Regulation Of Establishment Of Protein Localization Nervous System Development Regulation Of Cell Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Anatomical Structure Development Regulation Of Signal Transduction Response To Transforming Growth Factor Beta Positive Regulation Of Signal Transduction Intrinsic Apoptotic Signaling Pathway SMAD Protein Complex Assembly Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cellular Localization Response To Organic Substance Regulation Of Protein Localization Multicellular Organismal Development
Tagcloud ?			antisaccade assayed blink disrupt eeg electrodermal endophenotype endophenotypes exome exonic eye illumina kernel maf mapped movements neutral nonsynonymous pleasant pnpla7 polymorphic psychophysiological rare resting snp snps startle technologies theta
Tagcloud (Difference) ?			antisaccade assayed blink disrupt eeg electrodermal endophenotype endophenotypes exome exonic eye illumina kernel maf mapped movements neutral nonsynonymous pleasant pnpla7 polymorphic psychophysiological rare resting snp snps startle technologies theta
Tagcloud (Intersection) ?