NECTIN3 and KRTAP1-1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NECTIN3	KRTAP1-1
Description		nectin cell adhesion molecule 3	keratin associated protein 1-1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Adherens Junction Membrane Axon Dendrite Apical Junction Complex Cell-cell Contact Zone Synapse Postsynaptic Membrane Anchoring Junction Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity	Protein Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Fertilization Symbiont Entry Into Host Cell Retina Morphogenesis In Camera-type Eye Establishment Of Protein Localization To Plasma Membrane Cochlea Morphogenesis Cell-cell Adhesion Regulation Of Postsynapse Assembly Protein Localization To Cell Junction
Pathways		Adherens junctions interactions Nectin/Necl trans heterodimerization	Keratinization
Drugs
Diseases
GWAS		Feeling hurt ( 29500382)
Interacting Genes		24 interacting genes: AFDN CYSRT1 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-1 KRTAP4-11 KRTAP4-2 KRTAP5-11 KRTAP5-9 KRTAP9-3 NBPF19 NECTIN1 NECTIN2 NOTCH2NLA OTX1 PARD3 PICK1 PVR RGS20 TIGIT	218 interacting genes: ADAM12 ADAMTSL3 ADAMTSL4 AGXT AKR7A3 ALDH3B1 ALPP AQP1 ASPSCR1 ATG9A BCAM C10orf62 C11orf87 C19orf38 CAMK2B CATIP CATSPER1 CD300LG CERK CHIC2 CHRD CHRNG CLDN2 CNNM3 CREB5 CRH CRY2 CSF1 CST2 CTRC CTSZ CYSLTR2 CYSRT1 DHRS1 DMRT3 DOCK2 DRD5 EFNA3 EMC7 FAM221A FAM76B FAM90A1 FARS2 FBXW5 FEZF1 FKBP1B FOXD4L3 FRS3 FZD10 GARIN6 GLP1R GLYAT GNE GRN GSTP1 GUCD1 HCK HEY2 HHEX HOXA1 HOXB5 HOXB9 HOXC8 HPCAL1 HSBP1 HSPA12B HYAL2 IFITM2 IGSF8 IL16 INS ITGB4 ITGB5 JOSD1 KLHL38 KLK8 KRT20 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP13-2 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LNX1 LRFN4 LRRN4 MAGOHB MAPKBP1 MELTF MGAT5B MRGBP MRPL23 MT1B MXD3 MXI1 MYOM1 NECTIN2 NECTIN3 NMU NPDC1 NR1D2 NTM NUBP2 NUFIP2 OLFM2 OLIG3 OR14I1 OTX1 P2RX4 P2RY6 PCSK5 PDE9A PGAP6 PHLDA1 POU4F2 PRF1 PRKAB2 PRKAG1 PRPF31 PSMA1 PTK7 PTPMT1 PVR QPRT R3HDM2 RASD1 REM2 RNF111 RPS19BP1 RPS28 RPUSD3 RTN4RL1 SCARF1 SCNM1 SDC3 SEMA3B SHFL SLC23A1 SLC43A2 SLC68A1 SLC6A20 SLC7A11 SLIT1 SMARCE1 SMCP SMOC1 SNAI1 SNX18 SPACA9 SPRY1 STK16 TAPBPL TCEANC TFAP2D TGFB1 TLE5 TNP2 TSFM VASN VGLL3 VSTM4 WNT11 ZBTB48 ZBTB9 ZDHHC1 ZFTRAF1 ZNF124 ZNF330 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF446 ZNF491 ZNF497 ZNF524 ZNF581 ZNF587 ZNF648 ZNF669 ZNF696 ZNF786 ZNF837
Entrez ID		25945	81851
HPRD ID		08454	12304
Ensembl ID		ENSG00000177707	ENSG00000188581
Uniprot IDs		Q9NQS3	Q07627
PDB IDs		4FOM
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Susceptibility To T Cell Mediated Cytotoxicity Cell-cell Contact Zone Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cell Adhesion Molecule Binding Apical Junction Complex Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Identical Protein Binding Cell Adhesion Mediator Activity Adherens Junction Leukocyte Mediated Cytotoxicity Hair Cycle Virus Receptor Activity Positive Regulation Of Immune Response To Tumor Cell Negative Regulation Of Innate Immune Response Regulation Of Leukocyte Mediated Cytotoxicity Symbiont Entry Into Host Cell Lymphocyte Mediated Immunity Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cytosol Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Positive Regulation Of T Cell Mediated Cytotoxicity Leukocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Tight Junction Diencephalon Morphogenesis Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Biological Process Involved In Interaction With Host Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Bicellular Tight Junction Assembly Regulation Of T Cell Mediated Cytotoxicity Cell-cell Junction Organization Cell Killing Tight Junction Assembly Tight Junction Organization Regulation Of Lymphocyte Mediated Immunity Sperm Mitochondrion Organization BBSome Binding Cell-cell Junction Coreceptor Activity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Protein Binding Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Identical Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Susceptibility To T Cell Mediated Cytotoxicity
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