PVRL3 and TIGIT

Number of citations of the paper that reports this interaction (PMID 21982860)
4

Data Source:
BioGRID (pull down)

		PVRL3	TIGIT
Gene Name		poliovirus receptor-related 3	T cell immunoreceptor with Ig and ITIM domains
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell-cell Adherens Junction Integral Component Of Membrane Apical Junction Complex Postsynaptic Membrane	Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding	Receptor Binding Protein Binding
	Biological Process	Lens Morphogenesis In Camera-type Eye Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Fertilization Single Organismal Cell-cell Adhesion Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Retina Morphogenesis In Camera-type Eye	Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of T Cell Activation
Pathways		Nectin/Necl trans heterodimerization Cell junction organization Cell-cell junction organization Adherens junctions interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 MLLT4 NOTCH2NL PARD3 PVR PVRL1 PVRL2 RGS20 TIGIT	4 interactors: PVR PVRL2 PVRL3 PVRL4
Entrez ID		25945	201633
HPRD ID		08454	08804
Ensembl ID			ENSG00000181847
Uniprot IDs		Q9NQS3	Q495A1
PDB IDs		4FOM	3Q0H 3RQ3 3UCR 3UDW
Enriched GO Terms of Interacting Partners?		Cell Junction Assembly Cell-cell Junction Organization Adherens Junction Organization Susceptibility To T Cell Mediated Cytotoxicity Viral Entry Into Host Cell Entry Into Host Cell Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immune Response To Tumor Cell Interaction With Host Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Viral Life Cycle Response To Virus Cellular Component Assembly Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of T Cell Mediated Cytotoxicity Cell Adhesion Regulation Of T Cell Mediated Cytotoxicity Locomotion Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Regulation Of Leukocyte Mediated Cytotoxicity Viral Process Sperm Mitochondrion Organization Fusion Of Virus Membrane With Host Plasma Membrane Positive Regulation Of Adaptive Immune Response Response To Other Organism Response To Biotic Stimulus Positive Regulation Of Innate Immune Response Regulation Of Adaptive Immune Response Cell Development Apical Constriction Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Epithelial Cell Development Establishment Of Endothelial Intestinal Barrier Asymmetric Cell Division Cell Differentiation Cell Part Morphogenesis Enamel Mineralization Virion Attachment To Host Cell Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Regulation Of Innate Immune Response Adhesion Of Symbiont To Host Positive Regulation Of Myelination Tooth Mineralization	Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immune Response To Tumor Cell Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Cell Adhesion Viral Entry Into Host Cell Entry Into Host Cell Cellular Component Assembly Viral Process Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Leukocyte Mediated Cytotoxicity Interaction With Host Positive Regulation Of T Cell Mediated Immunity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of Adaptive Immune Response Fertilization Sperm Mitochondrion Organization Positive Regulation Of Innate Immune Response Viral Life Cycle Regulation Of Adaptive Immune Response Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Fusion Of Virus Membrane With Host Plasma Membrane Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Regulation Of Innate Immune Response Response To Virus Virion Attachment To Host Cell Adhesion Of Symbiont To Host Positive Regulation Of Mast Cell Activation Acrosome Assembly Establishment Of Mitochondrion Localization Single Organismal Cell-cell Adhesion Positive Regulation Of Immune Response Spermatid Nucleus Differentiation Lens Morphogenesis In Camera-type Eye Response To Other Organism Response To Biotic Stimulus Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Mast Cell Activation Mitochondrion Localization
Tagcloud ?			abolish adapter asn227 disrupts dramatically engagement granule harbors immunoglobulin immunoreceptor itim itt killer killing ligation motif motifs nk phosphatidylinositol polarization poliovirus prematurely pvr recruit restoration ship1 tail terminate tyr225
Tagcloud (Difference) ?			abolish adapter asn227 disrupts dramatically engagement granule harbors immunoglobulin immunoreceptor itim itt killer killing ligation motif motifs nk phosphatidylinositol polarization poliovirus prematurely pvr recruit restoration ship1 tail terminate tyr225
Tagcloud (Intersection) ?