RAD1 and RPA2

Number of citations of the paper that reports this interaction (PubMedID 15897895)
50

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RAD1	RPA2
Description		RAD1 checkpoint DNA exonuclease	replication protein A2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Checkpoint Clamp Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm DNA Replication Factor A Complex Nuclear Body PML Body Site Of Double-strand Break
	Molecular Function	Damaged DNA Binding Protein Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity	DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding
	Biological Process	DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Substantia Nigra Development Meiotic Recombination Checkpoint Signaling Cellular Response To Ionizing Radiation	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair Nucleotide-excision Repair Mismatch Repair DNA Recombination DNA Damage Response Regulation Of Double-strand Break Repair Via Homologous Recombination Mitotic G1 DNA Damage Checkpoint Signaling Protein Localization To Chromosome Regulation Of DNA Damage Checkpoint
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)	HDL cholesterol levels ( 32203549) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)
Interacting Genes		24 interacting genes: COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEN1 HUS1 HUS1B MAP1LC3B MSH2 MSH3 MSH6 NEIL1 OGG1 POLB PRKN RAD17 RAD9B RHNO1 RPA1 RPA2 SIRT6 TDG TOPBP1 WRN	69 interacting genes: ACP5 AKAP9 APP ATM CALCOCO2 CASK CCNC CCNO CDK1 CEBPA CEP126 CFB COPS6 CRMP1 DMRTB1 EEF1A1 ERCC1 ERCC4 EXOSC7 GAPDH GOLM1 HERPUD1 HIRA HNRNPUL1 HUS1 LNX2 LRIF1 MARK2 MCM2 MCM5 MED31 MEN1 NDEL1 ORC1 ORC2 ORC5 PCM1 PIAS1 PIAS4 PRC1 PRKDC RAD1 RAD51 RAD52 RAD9A RBM14 RBM48 RNF20 RNF40 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SF1 SLC17A9 SMARCAL1 STAT3 TLE1 TP53 TUBB2A UNC119 UNG UTP14A WAS WRN XPA YWHAE ZBTB14
Entrez ID		5810	6118
HPRD ID		04400	01566
Ensembl ID		ENSG00000113456	ENSG00000117748
Uniprot IDs		O60671	B4DUL2 P15927
PDB IDs		3A1J 3G65 3GGR 6J8Y 7Z6H 8GNN 8WU8	1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF 4MQV 4OU0 8RK2 9MJ5
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Metabolic Process DNA Damage Response Cellular Response To Stress Base-excision Repair Double-strand Break Repair Damaged DNA Binding DNA Recombination Nucleic Acid Metabolic Process DNA Damage Checkpoint Signaling Response To Stress Recombinational Repair Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage Site Of Double-strand Break Protein Localization To Site Of Double-strand Break Mismatch Repair Mitotic DNA Damage Checkpoint Signaling Response To Radiation Mitotic DNA Integrity Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Cycle Phase Transition Chromosome Organization Mitotic Intra-S DNA Damage Checkpoint Signaling Nucleoplasm DNA Replication Checkpoint Signaling Negative Regulation Of Cell Cycle Process Oxidized Purine DNA Binding Protein Localization To Chromosome Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Mitotic DNA Replication Checkpoint Signaling Response To Ionizing Radiation Mismatched DNA Binding Regulation Of Cell Cycle Process Response To UV Single Guanine Insertion Binding Chromosome, Telomeric Region Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Telomere Maintenance Chromatin-protein Adaptor Activity Guanine/thymine Mispair Binding Nucleotide-excision Repair Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Telomere Organization Checkpoint Clamp Complex Negative Regulation Of DNA Metabolic Process Regulation Of DNA Recombination	DNA Metabolic Process DNA Repair Chromosome, Telomeric Region Double-strand Break Repair Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm DNA Damage Response Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Recombination Macromolecule Metabolic Process Response To Radiation Nucleus Telomere Maintenance Response To Ionizing Radiation Cellular Response To Stress Cellular Response To Radiation Nucleotide-excision Repair Telomere Organization DNA Replication Origin Binding Site Of Double-strand Break DNA Replication Regulation Of DNA Metabolic Process Damaged DNA Binding Chromosome Organization Single-stranded DNA Binding Mitotic DNA Integrity Checkpoint Signaling Nuclear Origin Of Replication Recognition Complex Cellular Response To Ionizing Radiation Regulation Of Cell Cycle Response To Light Stimulus Nucleotide-excision Repair Factor 1 Complex Response To Gamma Radiation DNA Replication Initiation Response To Stress Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process UV Protection Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling DNA Replication Factor A Complex Regulation Of Cellular Response To Stress Response To UV PML Body Replicative Senescence Mitotic DNA Damage Checkpoint Signaling Base-excision Repair Checkpoint Clamp Complex Regulation Of Macromolecule Metabolic Process
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