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RAD1 and MSH6
Number of citations of the paper that reports this interaction (PubMedID
20188637
)
89
Data Source:
BioGRID
(far western blotting)
RAD1
MSH6
Description
RAD1 checkpoint DNA exonuclease
mutS homolog 6
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Checkpoint Clamp Complex
Chromatin
Nucleus
Nucleoplasm
Chromosome
Golgi Apparatus
Cytosol
MutSalpha Complex
Molecular Function
Damaged DNA Binding
Protein Binding
Double-stranded DNA 3'-5' DNA Exonuclease Activity
Nucleotide Binding
Magnesium Ion Binding
Four-way Junction DNA Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
Double-stranded DNA Binding
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Enzyme Binding
Mismatched DNA Binding
Guanine/thymine Mispair Binding
Single Guanine Insertion Binding
Single Thymine Insertion Binding
Oxidized Purine DNA Binding
MutLalpha Complex Binding
Protein Homodimerization Activity
ADP Binding
Histone H3K36me3 Reader Activity
ATP-dependent DNA Damage Sensor Activity
Biological Process
DNA Damage Checkpoint Signaling
DNA Repair
DNA Damage Response
Substantia Nigra Development
Meiotic Recombination Checkpoint Signaling
Cellular Response To Ionizing Radiation
Meiotic Mismatch Repair
DNA Repair
Mismatch Repair
Chromatin Organization
DNA Damage Response
Spermatogenesis
Determination Of Adult Lifespan
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Somatic Hypermutation Of Immunoglobulin Genes
Somatic Recombination Of Immunoglobulin Gene Segments
Maintenance Of DNA Repeat Elements
Isotype Switching
Negative Regulation Of DNA Recombination
Intrinsic Apoptotic Signaling Pathway
Pathways
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Impaired BRCA2 binding to RAD51
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Defective Mismatch Repair Associated With MSH2
Defective Mismatch Repair Associated With MSH6
Drugs
Diseases
Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
Colorectal cancer
GWAS
Daytime sleep phenotypes (
27126917
)
General risk tolerance (MTAG) (
30643258
)
Heel bone mineral density (
30598549
)
Lifetime average cigarettes per day in chronic obstructive pulmonary disease (
21685187
)
Menopause (age at onset) (
26414677
)
Takayasu arteritis (
25604533
)
Tea consumption (
31046077
)
Interacting Genes
24 interacting genes:
COPS5
CSNK2A1
CSNK2A2
DNAJC7
FEN1
HUS1
HUS1B
MAP1LC3B
MSH2
MSH3
MSH6
NEIL1
OGG1
POLB
PRKN
RAD17
RAD9B
RHNO1
RPA1
RPA2
SIRT6
TDG
TOPBP1
WRN
20 interacting genes:
BARD1
BRCA1
CEBPA
CHAF1A
CREBBP
CSNK2A1
EP300
HRAS
HUS1
MAP2K1
MSH2
MUTYH
NANS
PCNA
PTEN
RAD1
RAD9A
SMC1A
SUMO2
WEE2-AS1
Entrez ID
5810
2956
HPRD ID
04400
07202
Ensembl ID
ENSG00000113456
ENSG00000116062
Uniprot IDs
O60671
A0A494C0M1
A0A8V8TPJ4
P52701
Q3SWU9
PDB IDs
3A1J
3G65
3GGR
6J8Y
7Z6H
8GNN
8WU8
2GFU
2O8B
2O8C
2O8D
2O8E
2O8F
6OQM
8AG6
Enriched GO Terms of Interacting Partners
?
DNA Repair
DNA Metabolic Process
DNA Damage Response
Cellular Response To Stress
Base-excision Repair
Double-strand Break Repair
Damaged DNA Binding
DNA Recombination
Nucleic Acid Metabolic Process
DNA Damage Checkpoint Signaling
Response To Stress
Recombinational Repair
Nucleobase-containing Compound Metabolic Process
Signal Transduction In Response To DNA Damage
Site Of Double-strand Break
Protein Localization To Site Of Double-strand Break
Mismatch Repair
Mitotic DNA Damage Checkpoint Signaling
Response To Radiation
Mitotic DNA Integrity Checkpoint Signaling
Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Cell Cycle Phase Transition
Chromosome Organization
Mitotic Intra-S DNA Damage Checkpoint Signaling
Nucleoplasm
DNA Replication Checkpoint Signaling
Negative Regulation Of Cell Cycle Process
Oxidized Purine DNA Binding
Protein Localization To Chromosome
Macromolecule Metabolic Process
Negative Regulation Of Cell Cycle
Mitotic DNA Replication Checkpoint Signaling
Response To Ionizing Radiation
Mismatched DNA Binding
Regulation Of Cell Cycle Process
Response To UV
Single Guanine Insertion Binding
Chromosome, Telomeric Region
Regulation Of Cell Cycle
Regulation Of Cell Cycle Phase Transition
Telomere Maintenance
Chromatin-protein Adaptor Activity
Guanine/thymine Mispair Binding
Nucleotide-excision Repair
Regulation Of DNA Metabolic Process
Negative Regulation Of Mitotic Cell Cycle
Telomere Organization
Checkpoint Clamp Complex
Negative Regulation Of DNA Metabolic Process
Regulation Of DNA Recombination
Cellular Response To Radiation
DNA Repair
DNA Damage Response
Response To Radiation
DNA Metabolic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Phase Transition
Damaged DNA Binding
Response To Ionizing Radiation
Cellular Response To Ionizing Radiation
Cellular Response To Stress
Negative Regulation Of Cell Cycle Process
DNA Damage Checkpoint Signaling
Response To Stress
Nucleic Acid Metabolic Process
Regulation Of Cell Cycle
Checkpoint Clamp Complex
Nucleobase-containing Compound Metabolic Process
Signal Transduction In Response To DNA Damage
Intracellular Signal Transduction
Regulation Of Cell Cycle Phase Transition
MutLalpha Complex Binding
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Nucleoplasm
Regulation Of Cell Cycle Process
Regulation Of Cellular Response To Stress
Negative Regulation Of Mitotic Cell Cycle
Nucleus
DNA Recombination
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic Intra-S DNA Damage Checkpoint Signaling
Histone H2AK127 Ubiquitin Ligase Activity
Histone H2AK129 Ubiquitin Ligase Activity
Regulation Of Transcription By RNA Polymerase II
BRCA1-BARD1 Complex
Chromatin Binding
Response To UV
Histone H3K27 Acetyltransferase Activity
Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
Mitotic DNA Damage Checkpoint Signaling
Mitotic DNA Integrity Checkpoint Signaling
Intrinsic Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Catabolic Process
Histone H3K18 Acetyltransferase Activity
N-terminal Peptidyl-lysine Acetylation
Peptide Lactyltransferase (CoA-dependent) Activity
Dinucleotide Insertion Or Deletion Binding
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Catabolic Process
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Tagcloud (Intersection)
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