RAD1 and DNAJC7

Number of citations of the paper that reports this interaction (PubMedID 11573955)
0

Data Source:
HPRD (in vivo, in vitro)

		RAD1	DNAJC7
Description		RAD1 checkpoint DNA exonuclease	DnaJ heat shock protein family (Hsp40) member C7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Checkpoint Clamp Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	Damaged DNA Binding Protein Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity	ATPase Activator Activity Protein Binding Heat Shock Protein Binding
	Biological Process	DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Substantia Nigra Development Meiotic Recombination Checkpoint Signaling Cellular Response To Ionizing Radiation	Protein Folding Regulation Of Cellular Response To Heat
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)	Major depressive disorder x sex interaction ( 34099189)
Interacting Genes		24 interacting genes: COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEN1 HUS1 HUS1B MAP1LC3B MSH2 MSH3 MSH6 NEIL1 OGG1 POLB PRKN RAD17 RAD9B RHNO1 RPA1 RPA2 SIRT6 TDG TOPBP1 WRN	17 interacting genes: BTG3 DISC1 HSP90AA1 HUS1 LCOR MKNK1 NF1 OGT PGR RAD1 RAD9A RSPH1 SMAD2 SMAD9 SMURF1 TP53 UBE4B
Entrez ID		5810	7266
HPRD ID		04400	07046
Ensembl ID		ENSG00000113456	ENSG00000168259
Uniprot IDs		O60671	Q99615
PDB IDs		3A1J 3G65 3GGR 6J8Y 7Z6H 8GNN 8WU8
Enriched GO Terms of Interacting Partners?		DNA Repair DNA Metabolic Process DNA Damage Response Cellular Response To Stress Base-excision Repair Double-strand Break Repair Damaged DNA Binding DNA Recombination Nucleic Acid Metabolic Process DNA Damage Checkpoint Signaling Response To Stress Recombinational Repair Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage Site Of Double-strand Break Protein Localization To Site Of Double-strand Break Mismatch Repair Mitotic DNA Damage Checkpoint Signaling Response To Radiation Mitotic DNA Integrity Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Cycle Phase Transition Chromosome Organization Mitotic Intra-S DNA Damage Checkpoint Signaling Nucleoplasm DNA Replication Checkpoint Signaling Negative Regulation Of Cell Cycle Process Oxidized Purine DNA Binding Protein Localization To Chromosome Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Mitotic DNA Replication Checkpoint Signaling Response To Ionizing Radiation Mismatched DNA Binding Regulation Of Cell Cycle Process Response To UV Single Guanine Insertion Binding Chromosome, Telomeric Region Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Telomere Maintenance Chromatin-protein Adaptor Activity Guanine/thymine Mispair Binding Nucleotide-excision Repair Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Telomere Organization Checkpoint Clamp Complex Negative Regulation Of DNA Metabolic Process Regulation Of DNA Recombination	Checkpoint Clamp Complex Intracellular Signal Transduction I-SMAD Binding Cellular Response To Ionizing Radiation Disordered Domain Specific Binding Response To Radiation DNA Damage Checkpoint Signaling Nucleoplasm Histone Deacetylase Binding Signal Transduction Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Neuroblast Proliferation Double-stranded DNA 3'-5' DNA Exonuclease Activity Negative Regulation Of Cell Cycle Nucleus Cellular Response To Radiation SMAD Protein Complex Protein Localization To Organelle Meiotic Cell Cycle Checkpoint Signaling Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Neuroblast Proliferation Cytoplasm Striated Muscle Cell Apoptotic Process Transforming Growth Factor Beta Receptor Binding Regulation Of Neural Precursor Cell Proliferation Neural Precursor Cell Proliferation Mitotic Intra-S DNA Damage Checkpoint Signaling Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Cell Cycle Process Transforming Growth Factor Beta Receptor Signaling Pathway Response To Salt Stress Muscle Cell Apoptotic Process DNA Replication Checkpoint Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Light Stimulus Apoptotic Signaling Pathway SMAD Protein Signal Transduction Establishment Of Protein Localization To Organelle Regulation Of Cellular Response To Growth Factor Stimulus R-SMAD Binding
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