PTPRG and PPFIA2

Number of citations of the paper that reports this interaction (PMID 9624153)
49

Data Source:
BioGRID (two hybrid)

		PTPRG	PPFIA2
Gene Name		protein tyrosine phosphatase, receptor type, G	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Extracellular Vesicular Exosome	Cytoplasm Cytosol Cell Surface Presynaptic Active Zone Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Identical Protein Binding	Protein Binding Protein Complex Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Brain Development Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Neuron Projection Development Peptidyl-tyrosine Dephosphorylation Toxin Transport Regulation Of Homophilic Cell Adhesion	Cell-matrix Adhesion Synaptic Transmission Neurotransmitter Secretion Glutamate Secretion
Pathways			Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Breast size ( 22747683) Fuchs's corneal dystrophy ( 20825314) Major depressive disorder ( 20125088) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) QT interval ( 20031603)	Schizophrenia ( 22885689)
Protein-Protein Interactions		4 interactors: DLG4 PPFIA1 PPFIA2 PPFIA3	13 interactors: CAST CDC5L ERC2 GIT1 ITSN1 PPFIA1 PPFIA3 PPFIBP1 PPFIBP2 PTPRD PTPRF PTPRG PTPRS
Entrez ID		5793	8499
HPRD ID		01478	04392
Ensembl ID			ENSG00000139220
Uniprot IDs		P23470 Q49A02	G3V200 O75334
PDB IDs		2H4V 2HY3 2NLK 2PBN 3JXH 3QCB 3QCC 3QCD 3QCE 3QCF 3QCG 3QCH 3QCI 3QCJ 3QCK 3QCL 3QCM 3QCN	3TAC 3TAD
Enriched GO Terms of Interacting Partners?		Glutamate Secretion Acid Secretion Dicarboxylic Acid Transport Secretion By Cell Neurotransmitter Secretion Synaptic Transmission Secretion Regulation Of Neurotransmitter Levels Amino Acid Transport Neurotransmitter Transport Cell-cell Signaling Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport Regulation Of Neuronal Synaptic Plasticity Establishment Of Localization In Cell Anion Transport Cellular Localization Regulation Of Synaptic Plasticity Cell-matrix Adhesion Cell-substrate Adhesion Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Regulation Of Synaptic Transmission Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Negative Regulation Of Receptor Internalization Negative Regulation Of Stress Fiber Assembly Ion Transport Locomotory Exploration Behavior Dendritic Spine Morphogenesis Maintenance Of Cell Polarity Synaptic Vesicle Maturation Negative Regulation Of Actin Filament Bundle Assembly Transport Regulation Of Short-term Neuronal Synaptic Plasticity Vocalization Behavior Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Dendritic Spine Development Protein Localization To Synapse Negative Regulation Of Receptor-mediated Endocytosis Signaling Dendritic Spine Organization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Negative Regulation Of Protein Localization To Plasma Membrane Cell Communication Cortical Actin Cytoskeleton Organization Exploration Behavior Postsynaptic Membrane Organization Establishment Or Maintenance Of Apical/basal Cell Polarity	Peptidyl-tyrosine Dephosphorylation Enzyme Linked Receptor Protein Signaling Pathway Protein Dephosphorylation Signaling Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Cell Communication Dephosphorylation Signal Transduction Glutamate Secretion Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Acid Secretion Dicarboxylic Acid Transport Ephrin Receptor Signaling Pathway Neurotransmitter Secretion Cell Surface Receptor Signaling Pathway Response To Stimulus Regulation Of Neurotransmitter Levels Synaptic Transmission Nervous System Development Amino Acid Transport Neurotransmitter Transport Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Receptor Binding Presynaptic Membrane Assembly Generation Of Neurons Negative Regulation Of Stress Fiber Assembly Presynaptic Membrane Organization Neurogenesis Negative Regulation Of Actin Filament Bundle Assembly Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Cellular Process Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Cell-cell Signaling
Tagcloud ?		australian australians borderline caucasian caucasians clu col8a2 corneal corneas dystrophy endothelium fed finger fuchs genotyped haplotype homoebox polymorphisms rs17466684 rs17595731 rs2286812 rs613872 rs9954153 snp snps tcf4 tgfbi viii zeb1
Tagcloud (Difference) ?		australian australians borderline caucasian caucasians clu col8a2 corneal corneas dystrophy endothelium fed finger fuchs genotyped haplotype homoebox polymorphisms rs17466684 rs17595731 rs2286812 rs613872 rs9954153 snp snps tcf4 tgfbi viii zeb1
Tagcloud (Intersection) ?