CREB3L1 and EBP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CREB3L1	EBP
Description		cAMP responsive element binding protein 3 like 1	EBP cholestenol delta-isomerase
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Nuclear Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding SMAD Binding Sequence-specific Double-stranded DNA Binding	C-8 Sterol Isomerase Activity Steroid Delta-isomerase Activity Protein Binding Hydrolase Activity Isomerase Activity Cholesterol-5,6-oxide Hydrolase Activity Identical Protein Binding Cholestenol Delta-isomerase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Negative Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Collagen Biosynthetic Process Response To Endoplasmic Reticulum Stress Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Extracellular Matrix Constituent Secretion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Sterol Biosynthetic Process Hemopoiesis Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Biosynthetic Process Via Lathosterol Ossification Involved In Bone Maturation
Pathways		CREB3 factors activate genes	Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol
Drugs			Tamoxifen
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Fasting blood glucose ( 22581228) HDL cholesterol levels ( 32203549) LDL cholesterol ( 30275531) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Schizophrenia ( 29483656) Serum metabolite levels ( 33031748) Systolic blood pressure ( 30578418)
Interacting Genes		195 interacting genes: ADAM33 ADGRE2 ADIPOQ AGPAT3 AGPAT4 AGPAT5 ALG8 ANKRD46 AOC3 APOD AQP10 AQP2 ARLN ARV1 ASGR1 BET1 BMP10 BNIP3 BRICD5 C11orf24 C5 CCL4L2 CD53 CD72 CD99L2 CFHR5 CFTR CIAO2A CLN6 CMTM3 CMTM7 CNIH2 COL8A2 COMT COX20 CREB3 CREB3L3 CREM CSGALNACT2 CTSA CTXN3 CXCL16 CYB561D2 CYBC1 CYP4F2 DDIT3 DOLK EBP EMP3 ENTPD3 ERG28 ERMP1 FA2H FAM3C FAXDC2 FETUB FXYD3 FXYD6 GAST GIMAP1 GIMAP5 GOLT1B GOSR2 GPR151 GPR25 GPR37L1 HACD2 HIF1A IL1RL1 INSIG2 ITGAM JAGN1 KCNK1 LEPROTL1 LHFPL5 LPAR3 LTC4S MAL MAL2 MALL MAN2B2 MARCHF2 MGAM MGST2 MGST3 MMD2 MS4A1 MS4A13 NAPB NAT8 NEU1 NINJ1 NINJ2 NRM NSG1 OLFM4 OR10AG1 ORMDL1 ORMDL2 PAQR6 PEDS1-UBE2V1 PEX16 PGAP2 PGRMC1 PLN PLP1 PLP2 PLPP4 PLPP6 PLPPR2 PMP22 PRKAB2 PTPN9 RFT1 RHBDD1 RHD RNASE10 RUNX1T1 RUSF1 SACM1L SCARF1 SCD SCGB1D1 SEC22A SEC22B SEC61G SEMA4G SFXN5 SLC13A2 SLC13A3 SLC16A13 SLC2A3 SLC30A8 SLC35A4 SLC35B1 SLC35B2 SLC35B4 SLC35H1 SLC39A2 SLC39A9 SLC52A1 SLC61A1 SLC7A1 SMCO4 SMIM1 SPOCK1 SQLE STX3 STX7 STX8 SYNGR1 SYNJ2BP TECR TEX264 TFRC TIMM23 TIMMDC1 TLCD1 TMBIM6 TMEM11 TMEM120B TMEM128 TMEM147 TMEM14A TMEM14B TMEM14C TMEM19 TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM234 TMEM239 TMEM50B TMEM86A TMIE TNF TNFRSF10C TNMD TRAM1L1 TSPAN2 TSPO TSPO2 UBIAD1 UNC93B1 VAMP1 VAMP2 VEZT VKORC1 WFDC2 YIPF6 ZDHHC15 ZDHHC22 ZFPL1	172 interacting genes: ABHD16A ANKRD46 APP AQP6 ARL13B ARL6IP6 ARLN ARV1 ATP13A1 BMP10 BNIP3 BTN2A2 C2 C2CD2L C5 C5orf46 CCDC167 CCL4L2 CD40 CD69 CD81 CDIPT CHODL CLDND2 CREB3 CREB3L1 CYB561 CYB5B CYP4F2 DEFB103A DEFB103B DEFB127 DNAJC30 EBPL EMC6 EMP1 ERG28 ERGIC3 ESRRG FA2H FAM209A FAXDC2 FCER1G FETUB FIS1 FKBP8 FUNDC2 FXYD3 FXYD6 GIMAP1 GIMAP5 GJB2 GJB6 GLP1R GOSR2 GPR152 HMOX2 HSD17B13 IER3IP1 INSIG2 JAGN1 LDLRAD1 LEMD1 LPCAT2 LRP10 LRRC59 LTC4S MFSD6 MITF MMP14 MS4A13 MTNR1B NAT8 NDUFA3 NDUFB11 NEU1 NINJ1 NINJ2 NKG7 ODF4 ORMDL1 ORMDL2 ORMDL3 OTOP3 PLLP PLP2 PLPP6 PMP22 PNLIPRP1 PTPN9 PVR RNF152 RTP2 RUSF1 SACM1L SCAMP4 SEC22B SERP1 SERP2 SFXN5 SLC10A6 SLC35G1 SLC3A2 SLC41A2 SMAGP SMCO4 SMIM1 SMIM3 SNORC STX12 STX1B STX5 STX6 STX7 STX8 SYNGR1 SYNJ2BP SYS1 TBC1D20 THBD TIMM23 TLCD1 TLCD4 TMBIM6 TMEM100 TMEM11 TMEM120B TMEM140 TMEM147 TMEM14B TMEM14C TMEM167B TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM239 TMEM242 TMEM243 TMEM254 TMEM31 TMEM42 TMEM51 TMEM60 TMEM65 TMEM86A TMEM86B TMEM97 TMIE TRARG1 TREX1 TSNARE1 TSPO2 UBE2J1 UBIAD1 UNC50 UNC93B1 USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAPA VAPB VMA12 YIF1A YIPF1 YIPF4 YIPF6 ZDHHC24 ZFPL1
Entrez ID		90993	10682
HPRD ID		16751	02192
Ensembl ID		ENSG00000157613	ENSG00000147155
Uniprot IDs		B2RA75 Q96BA8	A0A024QYX0 Q15125
PDB IDs			6OHT 6OHU 8W0R 8W0S
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity Lipid Metabolic Process Lipid Biosynthetic Process Golgi Membrane Sterol Biosynthetic Process Steroid Biosynthetic Process SNARE Complex Sterol Metabolic Process Membrane Lipid Metabolic Process Cholesterol Biosynthetic Process Structural Constituent Of Myelin Sheath Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Plasma Membrane Endomembrane System Leukotriene-C4 Synthase Activity Transmembrane Transport Chloride Channel Inhibitor Activity Organic Anion Transport Mitochondrial Membrane Small Molecule Biosynthetic Process Cholesterol Metabolic Process Sphingolipid Metabolic Process Establishment Of Protein Localization Membrane Fusion Steroid Metabolic Process Heme Biosynthetic Process Myelination Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Axon Ensheathment Vesicle Fusion CAMP Response Element Binding Protein Binding Bleb Assembly Membrane Organization Nuclear Envelope Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Organelle Membrane Fusion Azurophil Granule CDP-diacylglycerol Biosynthetic Process Carbohydrate Derivative Transport Syntaxin Binding Cellular Localization CDP-diacylglycerol Metabolic Process Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Leukotriene Metabolic Process	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity SNARE Complex Protein Binding Membrane Fusion Vesicle-mediated Transport Vesicle Fusion Organelle Membrane Fusion Organelle Fusion Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Membrane Organization Golgi Vesicle Transport Endomembrane System Cellular Localization Organelle Localization By Membrane Tethering SNARE Binding Vesicle Organization Membrane Docking Establishment Of Protein Localization Vesicle Docking Intracellular Transport Golgi Membrane Establishment Of Localization In Cell Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane SNARE Complex Assembly Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Secretion By Cell Chemical Homeostasis Negative Regulation Of Sphingolipid Biosynthetic Process Protein Transport Serine Palmitoyltransferase Complex Exocytosis Establishment Of Protein Localization To Membrane Endoplasmic Reticulum Unfolded Protein Response Sterol Biosynthetic Process Transport Vesicle Regulation Of Cellular Localization Alkenylglycerophosphocholine Hydrolase Activity Intracellular Chemical Homeostasis Host-mediated Activation Of Viral Genome Replication Golgi Apparatus Syntaxin Binding Nuclear Inner Membrane Host-mediated Perturbation Of Viral Genome Replication Sphingomyelin Biosynthetic Process Intracellular Protein Localization Phagocytic Vesicle
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