CREB3L1 and SEC22B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CREB3L1	SEC22B
Description		cAMP responsive element binding protein 3 like 1	SEC22 homolog B, vesicle trafficking protein
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome
	Molecular Function	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding SMAD Binding Sequence-specific Double-stranded DNA Binding	SNAP Receptor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Negative Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Collagen Biosynthetic Process Response To Endoplasmic Reticulum Stress Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Extracellular Matrix Constituent Secretion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process Membrane Fusion Negative Regulation Of Autophagosome Assembly
Pathways		CREB3 factors activate genes	ER-Phagosome pathway COPII-mediated vesicle transport Cargo concentration in the ER COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Fasting blood glucose ( 22581228) HDL cholesterol levels ( 32203549) LDL cholesterol ( 30275531) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Schizophrenia ( 29483656) Serum metabolite levels ( 33031748) Systolic blood pressure ( 30578418)	Iris color (L* coordinate) ( 30895295)
Interacting Genes		195 interacting genes: ADAM33 ADGRE2 ADIPOQ AGPAT3 AGPAT4 AGPAT5 ALG8 ANKRD46 AOC3 APOD AQP10 AQP2 ARLN ARV1 ASGR1 BET1 BMP10 BNIP3 BRICD5 C11orf24 C5 CCL4L2 CD53 CD72 CD99L2 CFHR5 CFTR CIAO2A CLN6 CMTM3 CMTM7 CNIH2 COL8A2 COMT COX20 CREB3 CREB3L3 CREM CSGALNACT2 CTSA CTXN3 CXCL16 CYB561D2 CYBC1 CYP4F2 DDIT3 DOLK EBP EMP3 ENTPD3 ERG28 ERMP1 FA2H FAM3C FAXDC2 FETUB FXYD3 FXYD6 GAST GIMAP1 GIMAP5 GOLT1B GOSR2 GPR151 GPR25 GPR37L1 HACD2 HIF1A IL1RL1 INSIG2 ITGAM JAGN1 KCNK1 LEPROTL1 LHFPL5 LPAR3 LTC4S MAL MAL2 MALL MAN2B2 MARCHF2 MGAM MGST2 MGST3 MMD2 MS4A1 MS4A13 NAPB NAT8 NEU1 NINJ1 NINJ2 NRM NSG1 OLFM4 OR10AG1 ORMDL1 ORMDL2 PAQR6 PEDS1-UBE2V1 PEX16 PGAP2 PGRMC1 PLN PLP1 PLP2 PLPP4 PLPP6 PLPPR2 PMP22 PRKAB2 PTPN9 RFT1 RHBDD1 RHD RNASE10 RUNX1T1 RUSF1 SACM1L SCARF1 SCD SCGB1D1 SEC22A SEC22B SEC61G SEMA4G SFXN5 SLC13A2 SLC13A3 SLC16A13 SLC2A3 SLC30A8 SLC35A4 SLC35B1 SLC35B2 SLC35B4 SLC35H1 SLC39A2 SLC39A9 SLC52A1 SLC61A1 SLC7A1 SMCO4 SMIM1 SPOCK1 SQLE STX3 STX7 STX8 SYNGR1 SYNJ2BP TECR TEX264 TFRC TIMM23 TIMMDC1 TLCD1 TMBIM6 TMEM11 TMEM120B TMEM128 TMEM147 TMEM14A TMEM14B TMEM14C TMEM19 TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM234 TMEM239 TMEM50B TMEM86A TMIE TNF TNFRSF10C TNMD TRAM1L1 TSPAN2 TSPO TSPO2 UBIAD1 UNC93B1 VAMP1 VAMP2 VEZT VKORC1 WFDC2 YIPF6 ZDHHC15 ZDHHC22 ZFPL1	57 interacting genes: ABHD16A AIG1 AQP6 B3GAT3 CD79A CERS6 CLDN7 CLRN1 CPLX4 CREB3 CREB3L1 DPM3 EBP ELOVL4 ERGIC3 FAM174A FAM209A FCER1G FNDC9 GJA8 GJB5 GJB6 GORAB GPR152 GPX8 HIBADH HSD17B13 IFNGR2 JAGN1 KIR2DL3 LHFPL1 LHFPL5 LMNA MFF MGST2 MGST3 MMGT1 MRPS18B MUC1 NDUFAF2 REEP4 RELL2 RHBDD1 SERINC2 SLC10A6 SLC35H1 STX1A STX2 STX4 STX5 TLCD4 TM4SF19 TMEM132D TMEM139 TMEM167B TMEM229B TMEM86B
Entrez ID		90993	9554
HPRD ID		16751	04939
Ensembl ID		ENSG00000157613	ENSG00000265808
Uniprot IDs		B2RA75 Q96BA8	O75396
PDB IDs			2NUP 2NUT 3EGD 3EGX 8HR0
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity Lipid Metabolic Process Lipid Biosynthetic Process Golgi Membrane Sterol Biosynthetic Process Steroid Biosynthetic Process SNARE Complex Sterol Metabolic Process Membrane Lipid Metabolic Process Cholesterol Biosynthetic Process Structural Constituent Of Myelin Sheath Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Plasma Membrane Endomembrane System Leukotriene-C4 Synthase Activity Transmembrane Transport Chloride Channel Inhibitor Activity Organic Anion Transport Mitochondrial Membrane Small Molecule Biosynthetic Process Cholesterol Metabolic Process Sphingolipid Metabolic Process Establishment Of Protein Localization Membrane Fusion Steroid Metabolic Process Heme Biosynthetic Process Myelination Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Axon Ensheathment Vesicle Fusion CAMP Response Element Binding Protein Binding Bleb Assembly Membrane Organization Nuclear Envelope Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Organelle Membrane Fusion Azurophil Granule CDP-diacylglycerol Biosynthetic Process Carbohydrate Derivative Transport Syntaxin Binding Cellular Localization CDP-diacylglycerol Metabolic Process Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Leukotriene Metabolic Process	Membrane Endoplasmic Reticulum Membrane SNARE Complex SNARE Binding SNAP Receptor Activity Exocytosis Endoplasmic Reticulum Protein Binding Positive Regulation Of Regulated Secretory Pathway Connexin Complex Gap Junction Channel Activity Secretion By Cell Vesicle Docking Glutathione Peroxidase Activity Gap Junction Leukotriene-C4 Synthase Activity Cornified Envelope Assembly Organelle Localization By Membrane Tethering Gap Junction-mediated Intercellular Transport Positive Regulation Of Exocytosis Membrane Docking Secretion Vesicle Fusion Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Organelle Membrane Fusion Intercellular Transport SNARE Complex Assembly Lipid Metabolic Process Regulation Of Regulated Secretory Pathway Membrane Assembly Organelle Fusion Regulation Of Secretion Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
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