TREML1

Description		triggering receptor expressed on myeloid cells like 1
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Nuclear Speck Platelet Alpha Granule
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding
	Biological Process	Signal Transduction Calcium-mediated Signaling Platelet Activation Innate Immune Response
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Metabolite levels ( 23823483)
Interacting Genes		3 interacting genes: PTPN11 PTPN6 TMBIM6
Entrez ID		340205
HPRD ID		11645
Ensembl ID		ENSG00000161911
Uniprot IDs		Q86YW5
PDB IDs		2FRG 8CHE
Enriched GO Terms of Interacting Partners?		Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Neutrophil Activation Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Regulation Of Type I Interferon-mediated Signaling Pathway Phosphotyrosine Residue Binding T Cell Costimulation Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Immune System Process Myeloid Cell Development Negative Regulation Of T Cell Proliferation Protein Dephosphorylation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Cell Adhesion Molecule Binding Protein Tyrosine Phosphatase Activity Negative Regulation Of Leukocyte Proliferation Dephosphorylation Myeloid Leukocyte Activation Epididymis Development Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Phosphoprotein Phosphatase Activity Negative Regulation Of T Cell Activation Regulation Of Calcium Ion Transmembrane Transport Leukocyte Activation Involved In Immune Response Negative Regulation Of Leukocyte Cell-cell Adhesion Cell Activation Involved In Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Lymphocyte Activation Regulation Of Tumor Necrosis Factor Production Hemopoiesis Regulation Of T Cell Proliferation Regulation Of Cytokine-mediated Signaling Pathway Intestinal Epithelial Cell Migration Endoribonuclease Inhibitor Activity Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Calcium Ion Transport Negative Regulation Of Cell Activation Cerebellar Cortex Formation Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Signaling
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