ESPL1 and TRIM55

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		ESPL1	TRIM55
Gene Name		extra spindle pole bodies homolog 1 (S. cerevisiae)	tripartite motif containing 55
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Centrosome Cytosol	Nucleus Cytoplasm Microtubule
	Molecular Function	Catalytic Activity Protein Binding Cysteine-type Peptidase Activity	Signal Transducer Activity Zinc Ion Binding Identical Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Mitotic Cell Cycle Cytokinesis Proteolysis Apoptotic Process Establishment Of Mitotic Spindle Localization Homologous Chromosome Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Sister Chromatid Cohesion	Signal Transduction
Pathways		Separation of Sister Chromatids Mitotic Anaphase Cell Cycle, Mitotic M Phase Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS			Response to statin therapy ( 22666496)
Protein-Protein Interactions		6 interactors: PJA1 RFFL TRIM55 TRIM63 USP21 USP28	61 interactors: ACTA1 ANKRD1 ATP5B ATXN3 ATXN3L BRAP CKM DCAF6 DES EEF1G EHHADH EIF3E ESPL1 FHL2 FLNA FLNB FLNC GFM1 GMEB1 LMCD1 MDM4 MRPL19 MRPL41 MYBPC1 MYBPC3 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 OTUB1 OTUB2 PCGF1 PIAS1 PIAS2 PIAS3 RNF114 SQSTM1 STAM TCAP TNNI1 TNNI2 TNNI3 TRIM27 TRIM54 TRIM63 TTN UBE2D1 UBE2D2 UBE2D3 UCHL3 UCHL5 USP13 USP28 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		9700	84675
HPRD ID		06825	05927
Ensembl ID		ENSG00000135476	ENSG00000147573
Uniprot IDs		Q14674	Q9BYV6
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Cellular Protein Modification Process Protein Ubiquitination Protein Deubiquitination Protein Modification By Small Protein Conjugation Protein Modification By Small Protein Removal Regulation Of Proteolysis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Skeletal Muscle Atrophy Striated Muscle Atrophy Muscle Atrophy Negative Regulation Of Execution Phase Of Apoptosis Skeletal Muscle Adaptation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Histone Deubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Response To Dexamethasone Stimulus Regulation Of Fibroblast Migration Response To Dexamethasone Regulation Of Cellular Protein Metabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Response To Electrical Stimulus Regulation Of Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Metabolic Process Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus	Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Protein Deubiquitination Protein Modification By Small Protein Removal Actin Filament-based Movement Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Muscle Contraction Actin Filament-based Process Cellular Protein Catabolic Process Protein Catabolic Process Muscle System Process Protein K48-linked Deubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Striated Muscle Cell Development Cellular Protein Metabolic Process Muscle Structure Development Muscle Cell Development Protein K63-linked Deubiquitination Myofibril Assembly Proteolysis Cellular Protein Modification Process Striated Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Development Muscle Tissue Morphogenesis Actomyosin Structure Organization Muscle Organ Morphogenesis Cardiac Muscle Tissue Development Protein Metabolic Process Muscle Organ Development Protein Modification By Small Protein Conjugation Muscle Cell Differentiation Myosin Filament Assembly Catabolic Process Actin Cytoskeleton Organization Skeletal Muscle Thin Filament Assembly Cytoskeleton Organization Skeletal Myofibril Assembly Response To Muscle Stretch Heart Morphogenesis Striated Muscle Contraction Cellular Process
Tagcloud ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a smc3 undetected
Tagcloud (Difference) ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a smc3 undetected
Tagcloud (Intersection) ?