ESPL1 and RFFL

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		ESPL1	RFFL
Gene Name		extra spindle pole bodies homolog 1 (S. cerevisiae)	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Centrosome Cytosol	Golgi Membrane Tumor Necrosis Factor Receptor Superfamily Complex Cytoplasm Lysosome Cytosol Plasma Membrane Endosome Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Recycling Endosome Membrane
	Molecular Function	Catalytic Activity Protein Binding Cysteine-type Peptidase Activity	Protease Binding P53 Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Mitotic Cell Cycle Cytokinesis Proteolysis Apoptotic Process Establishment Of Mitotic Spindle Localization Homologous Chromosome Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Sister Chromatid Cohesion	Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of TOR Signaling Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		Separation of Sister Chromatids Mitotic Anaphase Cell Cycle, Mitotic M Phase Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS			QT interval ( 19305408)
Protein-Protein Interactions		6 interactors: PJA1 RFFL TRIM55 TRIM63 USP21 USP28	15 interactors: ATXN3 ATXN3L ESPL1 OTUB1 OTUB2 SFN STAM UBE2D1 UBE2D2 UBE2D3 UBE2G2 UCHL5 USP28 USP5 USP7
Entrez ID		9700	117584
HPRD ID		06825	11489
Ensembl ID		ENSG00000135476	ENSG00000092871
Uniprot IDs		Q14674	Q8WZ73
PDB IDs			1Y02
Enriched GO Terms of Interacting Partners?		Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Cellular Protein Modification Process Protein Ubiquitination Protein Deubiquitination Protein Modification By Small Protein Conjugation Protein Modification By Small Protein Removal Regulation Of Proteolysis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Proteasomal Protein Catabolic Process Cellular Protein Metabolic Process Skeletal Muscle Atrophy Striated Muscle Atrophy Muscle Atrophy Negative Regulation Of Execution Phase Of Apoptosis Skeletal Muscle Adaptation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Histone Deubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cellular Response To Dexamethasone Stimulus Regulation Of Fibroblast Migration Response To Dexamethasone Regulation Of Cellular Protein Metabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Response To Electrical Stimulus Regulation Of Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Metabolic Process Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus	Protein Deubiquitination Protein Modification By Small Protein Removal Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Deubiquitination Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Stress Protein K48-linked Ubiquitination Cellular Protein Modification Process Catabolic Process Regulation Of Proteolysis Regulation Of Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia DNA Repair Protein Polyubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Response To Stress TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Monoubiquitinated Protein Deubiquitination Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Chromosome Organization DNA Metabolic Process Cellular Response To Hypoxia Response To Abiotic Stimulus Cellular Response To Decreased Oxygen Levels Misfolded Or Incompletely Synthesized Protein Catabolic Process Cellular Response To Misfolded Protein Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Response To Misfolded Protein Protein K63-linked Deubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Activation Of Innate Immune Response
Tagcloud ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a smc3 undetected	biosynthesis boosting carefully causative defense es extend generating glycosylphosphatidylinositol live longevity mercaptoethanol mutagenized mutants nadph offers omission oxidase paraquat pigl platform pluripotency select span stressors throughput tiam1 transmit uncharacterized
Tagcloud (Difference) ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem nipbl novo partitioning rad21 recursive separase smc1a smc3 undetected	biosynthesis boosting carefully causative defense es extend generating glycosylphosphatidylinositol live longevity mercaptoethanol mutagenized mutants nadph offers omission oxidase paraquat pigl platform pluripotency select span stressors throughput tiam1 transmit uncharacterized
Tagcloud (Intersection) ?