ESPL1

Name	extra spindle pole bodies like 1, separase
Structure
Novel Interactors	1 novel interactors: TRAFD1
Interactors	7 interactors: MTNR1B PJA1 RFFL TRIM55 TRIM63 USP21 USP28
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Mitotic Spindle
	Molecular Function	Catalytic Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Mitotic Cell Cycle Nuclear Division Mitotic Cytokinesis Proteolysis Apoptotic Process Chromosome Segregation Meiosis I Establishment Of Mitotic Spindle Localization Homologous Chromosome Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Sister Chromatid Cohesion Mitotic Sister Chromatid Separation Meiotic Chromosome Separation Nuclear Chromosome Segregation
Pathways	Separation of Sister Chromatids
GWAS	Femoral neck bone mineral density ( 29499414 ) Lumbar spine bone mineral density ( 29499414 )
Entrez ID	9700
HPRD ID	06825
Ensembl ID	ENSG00000135476
Uniprot IDs	Q14674
PDB IDs	7NJ0 7NJ1
GO Terms Enriched among Interactors ?	Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Modification Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Metabolic Process Zinc Ion Binding Cysteine-type Deubiquitinase Activity Protein Deubiquitination Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein K48-linked Ubiquitination Protein Modification By Small Protein Removal Metal Ion Binding Cysteine-type Peptidase Activity Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep DeNEDDylase Activity Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Diapedesis Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy