ZBTB2 and STAT6

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ZBTB2	STAT6
Gene Name		zinc finger and BTB domain containing 2	signal transducer and activator of transcription 6, interleukin-4 induced
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nuclear Chromatin Nucleoplasm Cytoplasm Cytosol Membrane Raft
	Molecular Function	DNA Binding Metal Ion Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter T-helper 1 Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Positive Regulation Of Type I Interferon Production Mammary Gland Epithelial Cell Proliferation Interleukin-4-mediated Signaling Pathway Regulation Of Cell Proliferation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgE Isotypes Mammary Gland Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Reactive Nitrogen Species
Pathways			Signaling by PDGF Downstream signal transduction Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses STAT6-mediated induction of chemokines Innate Immune System
Drugs
Diseases
GWAS		Chronic myeloid leukemia ( 21540461)	Eosinophilic esophagitis (pediatric) ( 20208534) IgE levels ( 22075330)
Protein-Protein Interactions		3 interactors: CREBBP STAT6 TP53	37 interactors: ANKZF1 ANXA2 CEBPB CEBPE CEBPZ CREBBP DAZAP2 EEF1A1 EP300 ETS1 HIST2H3C IFNG IL4R IRF4 JAK1 LITAF NCOA1 NCOA2 NFKB1 NMI PPARG PRKCZ PTPN6 RCN3 RELA RLIM SND1 SRC STAT2 STAT3 TP53 TRIM24 VKORC1 WWP1 ZBTB2 ZNF407 ZNF92
Entrez ID		57621	6778
HPRD ID		10314	03302
Ensembl ID		ENSG00000181472	ENSG00000166888
Uniprot IDs		Q8N680	A8K4S9 B4DQB3 P42226
PDB IDs			1OJ5
Enriched GO Terms of Interacting Partners?		T Cell Lineage Commitment T Cell Activation Involved In Immune Response Positive Regulation Of Type I Interferon Production Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Type I Interferon Production Cellular Response To Oxygen Levels Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Notch Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process T Cell Differentiation Leukocyte Activation Involved In Immune Response Immune Response Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Cellular Response To Oxidative Stress Negative Regulation Of Macromitophagy T-helper 1 Cell Lineage Commitment Oligodendrocyte Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Gene Expression Lymphocyte Differentiation Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Helicase Activity N-terminal Peptidyl-lysine Acetylation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Cell Fate Commitment Response To Hypoxia Interleukin-4-mediated Signaling Pathway Positive Regulation Of Isotype Switching To IgE Isotypes Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Positive Regulation Of Cell Aging Germ-line Stem Cell Maintenance Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cytokine Production Negative Regulation Of Cellular Metabolic Process Immune System Process Mitochondrial DNA Repair	Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Gene Expression Regulation Of Gene Expression RNA Metabolic Process Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Defense Response Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Lipid Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Immune Response Cellular Nitrogen Compound Metabolic Process Regulation Of Cytokine Production Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Response To Hormone Response To Stress Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Immune System Process Positive Regulation Of Cytokine Production Response To Cytokine Regulation Of Cellular Process Response To Biotic Stimulus Cellular Response To Hormone Stimulus Cellular Metabolic Process Innate Immune Response Regulation Of Cell Differentiation
Tagcloud ?		actor alleviated base cancerous carcinogenesis constitutes detectable epigenetic finger hela hmc hplc hydroxymethylcytosine mc mention methylated methylcytosine mpl multifunctional notably oncoprotein p21 pull replacing sh sy5y ut7 verified	13r 13ralpha 2rgammac 4r alternative chains classical consist consists crucial exist form forms gammac hand hematopoietic il instead jak1 jak3 lack predominantly recently regard signals transduction transmitted tyrosine utilized
Tagcloud (Difference) ?		actor alleviated base cancerous carcinogenesis constitutes detectable epigenetic finger hela hmc hplc hydroxymethylcytosine mc mention methylated methylcytosine mpl multifunctional notably oncoprotein p21 pull replacing sh sy5y ut7 verified	13r 13ralpha 2rgammac 4r alternative chains classical consist consists crucial exist form forms gammac hand hematopoietic il instead jak1 jak3 lack predominantly recently regard signals transduction transmitted tyrosine utilized
Tagcloud (Intersection) ?