STAT6 and PRIM1

		STAT6	PRIM1
Description		signal transducer and activator of transcription 6	DNA primase subunit 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	DNA-directed RNA Polymerase Complex Nucleoplasm Alpha DNA Polymerase:primase Complex Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding Sequence-specific DNA Binding	Magnesium Ion Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Ribonucleotide Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II T-helper 1 Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Gene Expression Cytokine-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Transcription By RNA Polymerase II Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgE Isotypes Growth Hormone Receptor Signaling Pathway Via JAK-STAT Mammary Gland Morphogenesis Regulation Of Mast Cell Proliferation Positive Regulation Of Cold-induced Thermogenesis	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation
Pathways		Downstream signal transduction STAT6-mediated induction of chemokines Interleukin-4 and Interleukin-13 signaling	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs
Diseases
GWAS		Adult asthma ( 30787307) Alcohol consumption ( 31358974) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 31619474 31361310 31959851 30929738 32296059 29273806 34103634 27182965) Asthma (adult onset) ( 30929738 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Bitter alcoholic beverage consumption ( 31046077) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eosinophilic esophagitis ( 25407941) Eosinophilic esophagitis (pediatric) ( 20208534) Familial lung cancer ( 29924316) Headache ( 29397368) Height ( 31562340) IgE levels ( 22075330) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (adrenergics, inhalants) ( 31015401) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Migraine ( 27322543) Migraine without aura ( 27322543) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Sum eosinophil basophil counts ( 27863252)	Appendicular lean mass ( 33097823) Asthma ( 31619474) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677) Monocyte count ( 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 29403010)
Interacting Genes		39 interacting genes: ANKZF1 ANXA2 CEBPB CEBPE CEBPZ CREBBP DAZAP2 EEF1A1 EP300 ETS1 FBXO7 H3C14 IFNG IL4R IRF4 JAK1 LITAF NCOA1 NCOA2 NFKB1 NMI PKNOX1 PPARG PRKCZ PTPN6 RCN3 RELA RLIM SND1 SRC STAT2 STAT3 TP53 TRIM24 VKORC1 WWP1 ZBTB2 ZNF407 ZNF92	5 interacting genes: MDC1 MRPL38 OGT PRIM2 TP53
Entrez ID		6778	5557
HPRD ID		03302	08899
Ensembl ID		ENSG00000166888	ENSG00000198056
Uniprot IDs		A8K4S9 B4DQB3 P42226	P49642
PDB IDs		1OJ5 4Y5U 4Y5W 5D39 5NWM 5NWX 9BIG	4BPU 4BPW 4BPX 4LIK 4LIL 4MHQ 4RR2 5EXR 6R4S 6R4T 6R4U 6R5D 6R5E 6RB4 7OPL 7U5C 8B9D 8D0B 8D0K 8D9D 8QJ7 8VY3 9C8V
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Chromatin Regulation Of Immune System Process Nucleobase-containing Compound Biosynthetic Process Chromatin Binding Nucleus RNA Polymerase II Transcription Regulator Complex Macromolecule Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Defense Response Transcription Regulator Complex RNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Positive Regulation Of Defense Response MRNA Transcription DNA Binding Positive Regulation Of MiRNA Metabolic Process T Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process T-helper 17 Cell Lineage Commitment DNA-binding Transcription Factor Activity Negative Regulation Of Biosynthetic Process	Nucleoplasm DNA-binding Transcription Factor Activity Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Nickel Cation Transmembrane Transporter Activity Nickel Cation Transport Nickel Cation Transmembrane Transport Solute:proton Symporter Activity Vanadium Ion Transport Paraferritin Complex Lead Ion Transport Chromium Ion Transmembrane Transporter Activity Cobalt Ion Transmembrane Transporter Activity Transition Metal Ion Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Cadmium Ion Transmembrane Transporter Activity Vanadium Ion Transmembrane Transporter Activity Calmodulin-activated Dual Specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-activated 3',5'-cyclic-GMP Phosphodiesterase Activity Macromolecule Biosynthetic Process Growth Plate Cartilage Chondrocyte Growth Stem Cell Proliferation Negative Regulation Of Stem Cell Proliferation Regulation Of Stem Cell Proliferation Positive Regulation Of DNA Recombination Isotype Switching To IgE Isotypes Transcription Coactivator Binding Mammary Gland Morphogenesis T Cell Lineage Commitment Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Helicase Activity Regulation Of Carbohydrate Catabolic Process Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Autophagy Of Mitochondrion Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Proteolysis Germ Cell Nucleus Cellular Response To Actinomycin D Mitophagy
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