ZBTB2 and RASSF8

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		ZBTB2	RASSF8
Name		zinc finger and BTB domain containing 2	Ras association domain family member 8
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	None
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process	Signal Transduction
GWAS		Appendicular lean mass ( 33097823 ) Chronic myeloid leukemia ( 21540461 ) Monocyte count ( 32888494 ) Refractive error ( 32231278 )	Ankylosing spondylitis ( 30946743 ) Atrial fibrillation ( 29237688 ) Heel bone mineral density ( 30598549 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		25 interacting genes: CREBBP DAXX GABARAPL2 IP6K2 KAT5 LHX4 LNX1 MEOX2 MKLN1 MOS MRPL11 PICK1 PIN1 RASSF8 SP1 STAT6 SUMO1 SUMO2 SUV39H1 TENT5B TMC6 UBE2I ZBTB18 ZBTB49 ZMYND19	11 interacting genes: APP CCDC136 FRMD6 KDM1A PHOSPHO1 PPP1R13B PSMD4 TXLNA UBC YWHAG ZBTB2
Entrez ID		57621	11228
HPRD ID		10314	07084
Ensembl ID		ENSG00000181472	ENSG00000123094
Uniprot IDs		Q8N680	A8K8G8 Q8NHQ8
PDB IDs		Not available	2CS4
GO Terms Enriched among Interactors		Postsynaptic Cytosol Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cellular Response To Nutrient Levels Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Starvation Presynaptic Cytosol Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Starvation Negative Regulation Of RNA Metabolic Process PML Body Small Protein Activating Enzyme Binding Protein Stabilization Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Cellular Response To Glucose Starvation Transcription Coactivator Binding Negative Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Negative Regulation Of DNA-templated Transcription Response To Nutrient Levels Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Peptidyl-lysine Acetylation Positive Regulation Of DNA Recombination Nucleus Regulation Of Protein Stability Protein Tag Activity Regulation Of Gene Expression Negative Regulation Of Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Acetyltransferase Activity Regulation Of DNA Repair Cellular Response To Cadmium Ion SUMO Transferase Activity Transcription Factor Binding	None