ZBTB2 and MKLN1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ZBTB2	MKLN1
Name		zinc finger and BTB domain containing 2	muskelin 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Ubiquitin Ligase Complex Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Cell Cortex Cell Projection Synapse Postsynapse Postsynaptic Endosome Membrane GABA-ergic Synapse Postsynaptic Specialization Membrane Of Symmetric Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process	Regulation Of Receptor Internalization Cell-matrix Adhesion Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Organization Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Vesicle-mediated Transport In Synapse
Pathways		None	Regulation of pyruvate metabolism
GWAS		Appendicular lean mass ( 33097823 ) Chronic myeloid leukemia ( 21540461 ) Monocyte count ( 32888494 ) Refractive error ( 32231278 )	Asthma (childhood onset) ( 23829686 ) Bipolar disorder ( 31043756 ) Bipolar disorder (early onset) ( 27769005 ) Cutaneous malignant melanoma ( 32341527 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Heel bone mineral density ( 30598549 ) Hyperglycemia in higher physical activity ( 30327367 ) Hypertension ( 28273873 ) Lung cancer in never smokers ( 28604730 ) Male-pattern baldness ( 28196072 ) Metabolite levels ( 23823483 ) Myeloproliferative neoplasms ( 33057200 ) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095 ) Pancreatic cancer ( 25086665 ) PR interval ( 30046033 32439900 ) Refractive error ( 32231278 ) Resting heart rate ( 27798624 ) Staphylococcus aureus nasal carriage (persistent) ( 26569114 ) Systolic blood pressure ( 28135244 ) Vitamin D levels ( 25208829 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) Youthful appearance (self-reported) ( 32339537 )
Interacting Genes		25 interacting genes: CREBBP DAXX GABARAPL2 IP6K2 KAT5 LHX4 LNX1 MEOX2 MKLN1 MOS MRPL11 PICK1 PIN1 RASSF8 SP1 STAT6 SUMO1 SUMO2 SUV39H1 TENT5B TMC6 UBE2I ZBTB18 ZBTB49 ZMYND19	5 interacting genes: CYREN LAMTOR5 MORC3 PTGER3 ZBTB2
Entrez ID		57621	4289
HPRD ID		10314	16129
Ensembl ID		ENSG00000181472	ENSG00000128585
Uniprot IDs		Q8N680	B4DG30 C9J7E8 Q9UL63
PDB IDs		Not available	8TTQ
GO Terms Enriched among Interactors		Postsynaptic Cytosol Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cellular Response To Nutrient Levels Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Starvation Presynaptic Cytosol Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Starvation Negative Regulation Of RNA Metabolic Process PML Body Small Protein Activating Enzyme Binding Protein Stabilization Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Cellular Response To Glucose Starvation Transcription Coactivator Binding Negative Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Negative Regulation Of DNA-templated Transcription Response To Nutrient Levels Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Peptidyl-lysine Acetylation Positive Regulation Of DNA Recombination Nucleus Regulation Of Protein Stability Protein Tag Activity Regulation Of Gene Expression Negative Regulation Of Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Acetyltransferase Activity Regulation Of DNA Repair Cellular Response To Cadmium Ion SUMO Transferase Activity Transcription Factor Binding	Regulation Of Gastric Acid Secretion Positive Regulation Of Fever Generation Negative Regulation Of Gastric Acid Secretion Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Intestine Smooth Muscle Contraction Regulation Of Fever Generation Regulation Of Cytokine Production FNIP-folliculin RagC/D GAP Ragulator Complex Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Immunoglobulin V(D)J Recombination