ZBTB2 and IP6K2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ZBTB2	IP6K2
Name		zinc finger and BTB domain containing 2	inositol hexakisphosphate kinase 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Inositol-1,3,4,5,6-pentakisphosphate Kinase Activity Inositol Hexakisphosphate Kinase Activity Diphosphoinositol Pentakisphosphate Kinase Activity Inositol Hexakisphosphate 5-kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Inositol 5-diphosphate Pentakisphosphate 5-kinase Activity Diphosphoinositol Tetrakisphosphate Kinase Activity Flavonoid Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process	Lipid Metabolic Process Negative Regulation Of Cell Growth Inositol Phosphate Biosynthetic Process Positive Regulation Of Apoptotic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Phosphate Biosynthetic Process Protein Stabilization Organophosphate Biosynthetic Process Cellular Response To Flavonoid
Pathways		None	Synthesis of IPs in the nucleus Interferon alpha/beta signaling
GWAS		Appendicular lean mass ( 33097823 ) Chronic myeloid leukemia ( 21540461 ) Monocyte count ( 32888494 ) Refractive error ( 32231278 )	Adult body size ( 32376654 ) Age at first birth ( 34211149 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive function ( 25644384 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Diastolic blood pressure ( 27841878 ) Eosinophil count ( 32888494 ) Experiencing mood swings ( 29500382 ) Feeling fed-up ( 29500382 ) General cognitive ability ( 29844566 ) HDL cholesterol ( 30275531 ) Household income (MTAG) ( 31844048 ) Inflammatory bowel disease ( 23128233 28067908 ) Lipoprotein (a) levels ( 33730874 ) Morning person ( 30696823 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Refractive error ( 32231278 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 25082827 ) Waist circumference adjusted for body mass index ( 34021172 )
Interacting Genes		25 interacting genes: CREBBP DAXX GABARAPL2 IP6K2 KAT5 LHX4 LNX1 MEOX2 MKLN1 MOS MRPL11 PICK1 PIN1 RASSF8 SP1 STAT6 SUMO1 SUMO2 SUV39H1 TENT5B TMC6 UBE2I ZBTB18 ZBTB49 ZMYND19	7 interacting genes: HSP90AA1 LNX2 MEOX2 PLOD3 PLSCR1 RBPMS ZBTB2
Entrez ID		57621	51447
HPRD ID		10314	07380
Ensembl ID		ENSG00000181472	ENSG00000068745
Uniprot IDs		Q8N680	B2RCP4 C9JRM0 Q9UHH9
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Postsynaptic Cytosol Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cellular Response To Nutrient Levels Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Starvation Presynaptic Cytosol Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Starvation Negative Regulation Of RNA Metabolic Process PML Body Small Protein Activating Enzyme Binding Protein Stabilization Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Cellular Response To Glucose Starvation Transcription Coactivator Binding Negative Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Negative Regulation Of DNA-templated Transcription Response To Nutrient Levels Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Peptidyl-lysine Acetylation Positive Regulation Of DNA Recombination Nucleus Regulation Of Protein Stability Protein Tag Activity Regulation Of Gene Expression Negative Regulation Of Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Acetyltransferase Activity Regulation Of DNA Repair Cellular Response To Cadmium Ion SUMO Transferase Activity Transcription Factor Binding	Response To Unfolded Protein Rho GDP-dissociation Inhibitor Binding CTP Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process DATP Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Phosphatidylserine Biosynthetic Process Mercury Ion Binding Lead Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Hydroxylysine Biosynthetic Process Procollagen Glucosyltransferase Activity Procollagen-lysine 5-dioxygenase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Basement Membrane Assembly Procollagen Galactosyltransferase Activity MRNA CDS Binding