ZBTB2 and ZBTB49

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZBTB2	ZBTB49
Description		zinc finger and BTB domain containing 2	zinc finger and BTB domain containing 49
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Cytoskeleton
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Chronic myeloid leukemia ( 21540461) Monocyte count ( 32888494) Refractive error ( 32231278)	Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444)
Interacting Genes		25 interacting genes: CREBBP DAXX GABARAPL2 IP6K2 KAT5 LHX4 LNX1 MEOX2 MKLN1 MOS MRPL11 PICK1 PIN1 RASSF8 SP1 STAT6 SUMO1 SUMO2 SUV39H1 TENT5B TMC6 UBE2I ZBTB18 ZBTB49 ZMYND19	12 interacting genes: CEP70 CIB1 EP300 GOPC PICK1 POT1 TP53 TRAF2 TRAF3 VAC14 ZBTB2 ZBTB8A
Entrez ID		57621	166793
HPRD ID		10314	10335
Ensembl ID		ENSG00000181472	ENSG00000168826
Uniprot IDs		Q8N680	Q6ZSB9
PDB IDs
Enriched GO Terms of Interacting Partners?		Postsynaptic Cytosol Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cellular Response To Nutrient Levels Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Starvation Presynaptic Cytosol Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Starvation Negative Regulation Of RNA Metabolic Process PML Body Small Protein Activating Enzyme Binding Protein Stabilization Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Cellular Response To Glucose Starvation Transcription Coactivator Binding Negative Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Negative Regulation Of DNA-templated Transcription Response To Nutrient Levels Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Peptidyl-lysine Acetylation Positive Regulation Of DNA Recombination Nucleus Regulation Of Protein Stability Protein Tag Activity Regulation Of Gene Expression Negative Regulation Of Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Acetyltransferase Activity Regulation Of DNA Repair Cellular Response To Cadmium Ion SUMO Transferase Activity Transcription Factor Binding	Regulation Of DNA-binding Transcription Factor Activity Transcription Coactivator Binding Identical Protein Binding Tumor Necrosis Factor-mediated Signaling Pathway Thioesterase Binding CD40 Receptor Complex Regulation Of Cellular Component Organization TORC2 Signaling Positive Regulation Of DNA-binding Transcription Factor Activity Apoptotic Signaling Pathway Regulation Of Organelle Organization Negative Regulation Of Cellular Component Organization Programmed Necrotic Cell Death Negative Regulation Of Telomere Maintenance Via Telomerase Platelet Formation Cytokine-mediated Signaling Pathway Apoptotic Process T Cell Lineage Commitment Intrinsic Apoptotic Signaling Pathway Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Tumor Necrosis Factor Receptor Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Programmed Cell Death Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Death RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Telomere Maintenance Positive Regulation Of Gene Expression, Epigenetic Regulation Of Phosphorus Metabolic Process Somitogenesis Peptidyl-lysine Propionylation Segmentation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Transcription Initiation-coupled Chromatin Remodeling Histone Butyryltransferase Activity Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Levels Histone Crotonyltransferase Activity Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Cellular Response To Glucose Starvation Regulation Of Telomere Maintenance Via Telomere Lengthening TORC2 Complex Disassembly
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