ZBTB2 and TMC6

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ZBTB2	TMC6
Name		zinc finger and BTB domain containing 2	transmembrane channel like 6
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Nuclear Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Mechanosensitive Monoatomic Ion Channel Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process	Intracellular Zinc Ion Homeostasis Monoatomic Ion Transmembrane Transport Protein Stabilization
Pathways		None	Neutrophil degranulation
Diseases		None	Epidermodysplasia verruciformis
GWAS		Appendicular lean mass ( 33097823 ) Chronic myeloid leukemia ( 21540461 ) Monocyte count ( 32888494 ) Refractive error ( 32231278 )	Glycated hemoglobin levels ( 31213470 34059833 29170429 28887542 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin A1c levels ( 29403010 ) Hemoglobin levels ( 32327693 ) hemolysis of donated blood (cold-storage) ( 34014839 ) High light scatter reticulocyte count ( 32888494 27863252 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Mean corpuscular hemoglobin ( 29403010 32888494 27863252 ) Mean corpuscular volume ( 27863252 32888494 29403010 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 27863252 ) Red blood cell count ( 27863252 29403010 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Serum uric acid levels ( 29559957 )
Interacting Genes		25 interacting genes: CREBBP DAXX GABARAPL2 IP6K2 KAT5 LHX4 LNX1 MEOX2 MKLN1 MOS MRPL11 PICK1 PIN1 RASSF8 SP1 STAT6 SUMO1 SUMO2 SUV39H1 TENT5B TMC6 UBE2I ZBTB18 ZBTB49 ZMYND19	3 interacting genes: CCR9 ZBTB2 ZDHHC17
Entrez ID		57621	11322
HPRD ID		10314	08386
Ensembl ID		ENSG00000181472	ENSG00000141524
Uniprot IDs		Q8N680	A0A8V8TLY1 Q7Z403
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Postsynaptic Cytosol Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cellular Response To Nutrient Levels Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Starvation Presynaptic Cytosol Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Starvation Negative Regulation Of RNA Metabolic Process PML Body Small Protein Activating Enzyme Binding Protein Stabilization Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Cellular Response To Glucose Starvation Transcription Coactivator Binding Negative Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Negative Regulation Of DNA-templated Transcription Response To Nutrient Levels Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Peptidyl-lysine Acetylation Positive Regulation Of DNA Recombination Nucleus Regulation Of Protein Stability Protein Tag Activity Regulation Of Gene Expression Negative Regulation Of Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Acetyltransferase Activity Regulation Of DNA Repair Cellular Response To Cadmium Ion SUMO Transferase Activity Transcription Factor Binding	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Gamma-delta T Cell Differentiation Gamma-delta T Cell Activation Lipoprotein Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity Protein Lipidation