MKLN1

Description		muskelin 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Cell Cortex Cell Projection Synapse Postsynapse Postsynaptic Endosome Membrane GABA-ergic Synapse Postsynaptic Specialization Membrane Of Symmetric Synapse
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Receptor Internalization Cell-matrix Adhesion Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Organization Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Vesicle-mediated Transport In Synapse
Pathways		Regulation of pyruvate metabolism
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 23829686) Bipolar disorder ( 31043756) Bipolar disorder (early onset) ( 27769005) Cutaneous malignant melanoma ( 32341527) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Hyperglycemia in higher physical activity ( 30327367) Hypertension ( 28273873) Lung cancer in never smokers ( 28604730) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Myeloproliferative neoplasms ( 33057200) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Pancreatic cancer ( 25086665) PR interval ( 30046033 32439900) Refractive error ( 32231278) Resting heart rate ( 27798624) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Systolic blood pressure ( 28135244) Vitamin D levels ( 25208829) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		5 interacting genes: CYREN LAMTOR5 MORC3 PTGER3 ZBTB2
Entrez ID		4289
HPRD ID		16129
Ensembl ID		ENSG00000128585
Uniprot IDs		B4DG30 C9J7E8 Q9UL63
PDB IDs		8TTQ
Enriched GO Terms of Interacting Partners?		Regulation Of Gastric Acid Secretion Positive Regulation Of Fever Generation Negative Regulation Of Gastric Acid Secretion Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Intestine Smooth Muscle Contraction Regulation Of Fever Generation Regulation Of Cytokine Production FNIP-folliculin RagC/D GAP Ragulator Complex Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Immunoglobulin V(D)J Recombination
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