MKLN1 and CYREN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MKLN1	CYREN
Description		muskelin 1	cell cycle regulator of NHEJ
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Cell Cortex Cell Projection Synapse Postsynapse Postsynaptic Endosome Membrane GABA-ergic Synapse Postsynaptic Specialization Membrane Of Symmetric Synapse	Nucleus Chromosome Cytoplasm Site Of Double-strand Break DNA Repair Complex
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	Damaged DNA Binding Protein Binding
	Biological Process	Regulation Of Receptor Internalization Cell-matrix Adhesion Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Organization Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Vesicle-mediated Transport In Synapse	DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Damage Response Immunoglobulin V(D)J Recombination Protein Localization To Site Of Double-strand Break Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Regulation of pyruvate metabolism
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 23829686) Bipolar disorder ( 31043756) Bipolar disorder (early onset) ( 27769005) Cutaneous malignant melanoma ( 32341527) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Hyperglycemia in higher physical activity ( 30327367) Hypertension ( 28273873) Lung cancer in never smokers ( 28604730) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Myeloproliferative neoplasms ( 33057200) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Pancreatic cancer ( 25086665) PR interval ( 30046033 32439900) Refractive error ( 32231278) Resting heart rate ( 27798624) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Systolic blood pressure ( 28135244) Vitamin D levels ( 25208829) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		5 interacting genes: CYREN LAMTOR5 MORC3 PTGER3 ZBTB2	5 interacting genes: ATM ERCC6L2 LRRK2 MFHAS1 MKLN1
Entrez ID		4289	78996
HPRD ID		16129	08333
Ensembl ID		ENSG00000128585	ENSG00000122783
Uniprot IDs		B4DG30 C9J7E8 Q9UL63	Q9BWK5
PDB IDs		8TTQ	6TYU
Enriched GO Terms of Interacting Partners?		Regulation Of Gastric Acid Secretion Positive Regulation Of Fever Generation Negative Regulation Of Gastric Acid Secretion Prostaglandin Receptor Activity Prostaglandin E Receptor Activity Intestine Smooth Muscle Contraction Regulation Of Fever Generation Regulation Of Cytokine Production FNIP-folliculin RagC/D GAP Ragulator Complex Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Immunoglobulin V(D)J Recombination	Cellular Response To Reactive Oxygen Species Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Cellular Response To Chemical Stress Determination Of Adult Lifespan Regulation Of Vacuole Organization Regulation Of Autophagosome Assembly Double-strand Break Repair Via Nonhomologous End Joining Response To Oxidative Stress Regulation Of Macrophage Activation Establishment Of RNA Localization To Telomere Cytoskeleton Regulation Of Cell Activation Establishment Of Protein-containing Complex Localization To Telomere Protein Autophosphorylation Positive Regulation Of Telomerase Catalytic Core Complex Assembly Nucleotide Binding Postsynaptic Endosome Membrane Postsynaptic Specialization Membrane Of Symmetric Synapse Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly DNA-dependent Protein Kinase Activity Histone H2AXS139 Kinase Activity Positive Regulation Of Protein Autoubiquitination Response To Curcumin Vacuole Organization Positive Regulation Of Autophagy Cellular Response To Nitrosative Stress Pre-B Cell Allelic Exclusion Cellular Response To Oxygen-containing Compound Peptidyl-serine Autophosphorylation Regulation Of Macroautophagy Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Dopamine Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport Double-strand Break Repair Response To Starvation Postsynapse
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