JCAD and MAP3K8

Data Source: HiPPIP (Novel)

		JCAD	MAP3K8
Name		junctional cadherin 5 associated	mitogen-activated protein kinase kinase kinase 8
Structure		No pdb structure
GO Annotations	Cellular Component	Cell-cell Junction Adherens Junction Cell Junction Ruffle Membrane Perinuclear Region Of Cytoplasm Anchoring Junction	Cytoplasm Cytosol
	Molecular Function	None	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Cell Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Sprouting Angiogenesis	MAPK Cascade Immune System Process Protein Phosphorylation Signal Transduction T Cell Costimulation Positive Regulation Of Inflammatory Response
Pathways		None	CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
GWAS		Alcohol use disorder (total score) ( 30336701 ) Coronary artery disease ( 33020668 ) Intraocular pressure ( 29617998 ) Myocardial infarction ( 33532862 )	Asthma ( 32296059 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 23128233 28067908 ) Systemising ( 31508503 ) Ulcerative colitis ( 28067908 )
Novel Interactors		2 novel interactors: IL2RA MAP3K8	9 novel interactors: ACP6 ADAM10 GAD2 JCAD LYZL2 MTPAP PARD3 PDK2 RANGAP1
Interacting Genes		2 interacting genes: DYRK1A YAP1	17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6
Entrez ID		57608	1326
HPRD ID		13864	01863
Ensembl ID		ENSG00000165757	ENSG00000107968
Uniprot IDs		Q9P266	P41279 Q6FG25
PDB IDs		Not available	4Y83 4Y85 5IU2
GO Terms Enriched among Interactors		Positive Regulation Of Lymphocyte Activation Protein Serine/threonine Kinase Activity Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Phosphate-containing Compound Metabolic Process Phosphorylation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Inflammatory Response Regulation Of T Cell Activation Protein Phosphorylation Regulation Of Leukocyte Cell-cell Adhesion Protein Serine Kinase Activity RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Transcription Coactivator Activity Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Neurofilament Splicing Factor Binding Regulation Of Heterochromatin Formation Histone H3T45 Kinase Activity Activated T Cell Proliferation Regulation Of T Cell Homeostatic Proliferation Interleukin-2 Receptor Complex Cytokine-mediated Signaling Pathway Interleukin-2 Binding Interleukin-2-mediated Signaling Pathway Interleukin-2 Receptor Activity Activation-induced Cell Death Of T Cells Regulation Of T Cell Tolerance Induction Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Branch Elongation Of An Epithelium Lateral Mesoderm Development Intestinal Epithelial Cell Development Bud Elongation Involved In Lung Branching Regulation Of Nephron Tubule Epithelial Cell Differentiation TEAD-YAP Complex Notochord Development Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Female Germ Cell Nucleus Cardiac Muscle Tissue Regeneration Enterocyte Differentiation Paraxial Mesoderm Development Intestinal Epithelial Cell Differentiation Columnar/cuboidal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway MAP Kinase Kinase Kinase Activity	Non-canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Intracellular Signaling Cassette Response To Cytokine Response To Peptide Tumor Necrosis Factor-mediated Signaling Pathway Response To Tumor Necrosis Factor CD40 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Intracellular Signal Transduction Cell Surface Toll-like Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Positive Regulation Of Signal Transduction Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cytokine Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Signal Transduction Toll-like Receptor 4 Signaling Pathway Protein Kinase Activity Positive Regulation Of DNA-binding Transcription Factor Activity Inflammatory Response Positive Regulation Of Immune System Process Response To Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cytokine Production Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Defense Response Positive Regulation Of DNA-templated Transcription NF-kappaB P50/p65 Complex Positive Regulation Of Cytokine-mediated Signaling Pathway Kinase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Interleukin-12 Production Positive Regulation Of Response To Cytokine Stimulus