MAP3K8 and ADAM10

		MAP3K8	ADAM10
Description		mitogen-activated protein kinase kinase kinase 8	ADAM metallopeptidase domain 10
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Golgi-associated Vesicle Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Postsynaptic Density Membrane Clathrin-coated Vesicle Axon Dendrite Cytoplasmic Vesicle Specific Granule Membrane Cell Projection Pore Complex Extracellular Exosome Anchoring Junction Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum Synaptic Membrane Tetraspanin-enriched Microdomain Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Endopeptidase Activity Metalloendopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Protein Kinase Binding Protein Homodimerization Activity Metal Ion Binding Metallodipeptidase Activity Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
	Biological Process	MAPK Cascade Immune System Process Protein Phosphorylation Signal Transduction T Cell Costimulation Positive Regulation Of Inflammatory Response	In Utero Embryonic Development Proteolysis Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Regulation Of Notch Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of T Cell Chemotaxis Protein Processing Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Adherens Junction Organization Response To Tumor Necrosis Factor Epidermal Growth Factor Receptor Ligand Maturation Monocyte Activation Amyloid Precursor Protein Catabolic Process Pore Complex Assembly Constitutive Protein Ectodomain Proteolysis Cochlea Development Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynapse Organization Regulation Of Postsynapse Organization Protein Catabolic Process At Postsynapse Signaling Receptor Ligand Precursor Processing Regulation Of Vasculature Development Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation	Collagen degradation Degradation of the extracellular matrix Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Neutrophil degranulation Post-translational protein phosphorylation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Amyloid fiber formation
Drugs			XL784
Diseases
GWAS		Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Systemising ( 31508503) Ulcerative colitis ( 28067908)	Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 33589840) Apolipoprotein A1 levels ( 32203549) Chronotype ( 30696823) Diffusing capacity of carbon monoxide ( 30694715) Family history of Alzheimer's disease ( 30617256) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Metabolite levels ( 23823483) Schizophrenia ( 30285260)
Interacting Genes		17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6	7 interacting genes: AXL DLL1 EFNA1 EFNA2 EPHA3 SH3D19 TGFA
Entrez ID		1326	102
HPRD ID		01863	03723
Ensembl ID		ENSG00000107968	ENSG00000137845
Uniprot IDs		P41279 Q6FG25	O14672
PDB IDs		4Y83 4Y85 5IU2	6BDZ 6BE6 8ESV
Enriched GO Terms of Interacting Partners?		Non-canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Intracellular Signaling Cassette Response To Cytokine Response To Peptide Tumor Necrosis Factor-mediated Signaling Pathway Response To Tumor Necrosis Factor CD40 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Intracellular Signal Transduction Cell Surface Toll-like Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Positive Regulation Of Signal Transduction Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cytokine Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Signal Transduction Toll-like Receptor 4 Signaling Pathway Protein Kinase Activity Positive Regulation Of DNA-binding Transcription Factor Activity Inflammatory Response Positive Regulation Of Immune System Process Response To Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cytokine Production Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Defense Response Positive Regulation Of DNA-templated Transcription NF-kappaB P50/p65 Complex Positive Regulation Of Cytokine-mediated Signaling Pathway Kinase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Interleukin-12 Production Positive Regulation Of Response To Cytokine Stimulus	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Cell Surface Receptor Signaling Pathway Neuron Projection Guidance Axon Guidance Substrate Adhesion-dependent Cell Spreading Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Endocytosis Regulation Of Developmental Process Regulation Of Cell Adhesion Notch Signaling Pathway Involved In Arterial Endothelial Cell Fate Commitment Cerebellar Molecular Layer Formation Regulation Of Cell Differentiation Leukocyte Differentiation Tissue Remodeling Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Fasciculation Of Motor Neuron Axon Endothelial Tip Cell Fate Specification Cerebellar Purkinje Cell Layer Structural Organization Positive Regulation Of Cellular Component Organization Signal Transduction Protein Kinase Activity Protein Tyrosine Kinase Activity Plasma Membrane Neuron Projection Development Notochord Formation Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Side Of Membrane Fasciculation Of Sensory Neuron Axon Receptor Ligand Activity Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Compartment Pattern Specification Lateral Inhibition Blood Vessel Endothelial Cell Fate Specification Endothelial Cell Fate Specification Regulation Of Vesicle-mediated Transport Positive Regulation Of Skeletal Muscle Tissue Growth Loop Of Henle Development Somite Specification Positive Regulation Of Endocytosis Positive Regulation Of Pinocytosis Kinase Activity Neutrophil Clearance Cell-substrate Adhesion
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