MAP3K8 and PARD3

		MAP3K8	PARD3
Description		mitogen-activated protein kinase kinase kinase 8	par-3 family cell polarity regulator
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Endomembrane System Membrane Apical Plasma Membrane Cell Junction Internode Region Of Axon Apical Junction Complex Tight Junction Anchoring Junction PAR Polarity Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	MAPK Cascade Immune System Process Protein Phosphorylation Signal Transduction T Cell Costimulation Positive Regulation Of Inflammatory Response	Microtubule Cytoskeleton Organization Protein Targeting To Membrane Cell Adhesion Establishment Or Maintenance Of Cell Polarity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Intracellular Protein Localization Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Establishment Of Cell Polarity Cell Differentiation Positive Regulation Of Myelination Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Division Establishment Of Centrosome Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly Establishment Of Epithelial Cell Polarity
Pathways		CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions
Drugs
Diseases
GWAS		Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Systemising ( 31508503) Ulcerative colitis ( 28067908)	Acute lymphoblastic leukemia (childhood) ( 19684603) Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Corneal astigmatism ( 30306274) Emphysema-related traits ( 20709820) Estimated glomerular filtration rate ( 31015462) Gut microbiota relative abundance (Sutterella) ( 33208821) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 28552196) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Major depressive disorder ( 21621269) Parkinson's disease progression (composite) ( 33111402) Schizophrenia ( 21682944)
Interacting Genes		17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6	31 interacting genes: ACE2 CDC42 DYNLL1 F11R INSC LIMK2 NECTIN1 NECTIN3 PARD6A PARD6B PARD6G PATJ PLCB1 PLCB3 PNMA1 PRKCG PRKCI SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 TTN UBC YWHAB YWHAG YWHAH YWHAZ
Entrez ID		1326	56288
HPRD ID		01863	05994
Ensembl ID		ENSG00000107968	ENSG00000148498
Uniprot IDs		P41279 Q6FG25	Q8TEW0
PDB IDs		4Y83 4Y85 5IU2	2KOM
Enriched GO Terms of Interacting Partners?		Non-canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Intracellular Signaling Cassette Response To Cytokine Response To Peptide Tumor Necrosis Factor-mediated Signaling Pathway Response To Tumor Necrosis Factor CD40 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Intracellular Signal Transduction Cell Surface Toll-like Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Positive Regulation Of Signal Transduction Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cytokine Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Signal Transduction Toll-like Receptor 4 Signaling Pathway Protein Kinase Activity Positive Regulation Of DNA-binding Transcription Factor Activity Inflammatory Response Positive Regulation Of Immune System Process Response To Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cytokine Production Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Defense Response Positive Regulation Of DNA-templated Transcription NF-kappaB P50/p65 Complex Positive Regulation Of Cytokine-mediated Signaling Pathway Kinase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Interleukin-12 Production Positive Regulation Of Response To Cytokine Stimulus	Heteromeric SMAD Protein Complex Intracellular Signal Transduction I-SMAD Binding Tight Junction PAR Polarity Complex Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity SMAD Protein Complex Establishment Or Maintenance Of Apical/basal Cell Polarity SMAD Protein Signal Transduction Cell-cell Junction Organization Cytosol Protein-containing Complex Establishment Or Maintenance Of Cell Polarity Mesonephric Tubule Development Mesonephric Epithelium Development Identical Protein Binding Cytoplasm Regulation Of Cellular Component Organization Bicellular Tight Junction Tube Development Kidney Epithelium Development Positive Regulation Of Cell Differentiation Endoderm Development Regulation Of Protein Localization Anchoring Junction Ureteric Bud Development Co-SMAD Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Protein Localization Primary MiRNA Processing Golgi Localization Cell Junction Organization Intracellular Protein Localization Extracellular Exosome Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Transport Homomeric SMAD Protein Complex Cardiac Conduction System Development Regulation Of Cell Differentiation Intracellular Signaling Cassette Regulation Of Signaling Regulation Of Cell Communication Regulation Of Transport Signal Transduction Embryonic Pattern Specification Epithelium Development Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Localization Transcription Regulator Complex Response To Monosaccharide
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