TAOK1 and CSNK1E

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TAOK1	CSNK1E
Gene Name		TAO kinase 1	casein kinase 1, epsilon
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol Ribonucleoprotein Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Mitotic Cell Cycle DNA Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus G2 DNA Damage Checkpoint Spindle Checkpoint Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of JNK Cascade Regulation Of Cytoskeleton Organization Execution Phase Of Apoptosis	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Repair Protein Phosphorylation Endocytosis Organelle Organization Signal Transduction Circadian Rhythm Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Cellular Protein Localization Regulation Of Circadian Rhythm Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Organelle biogenesis and maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling G2/M Transition Assembly of the primary cilium Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic WNT mediated activation of DVL Loss of proteins required for interphase microtubule organizationÂ from the centrosome TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Loss of Nlp from mitotic centrosomes XAV939 inhibits tankyrase, stabilizing AXIN Centrosome maturation Signaling by WNT in cancer Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419 19110211 19820697 22423221) Platelet counts ( 22139419)
Protein-Protein Interactions		7 interactors: C8orf33 CSNK1E DYNC1I1 GEMIN7 MAP2K3 MARK1 WT1	40 interactors: AKAP9 ANKRD6 APC APP ARHGEF1 ARNTL AXIN1 AXIN2 BBS10 BID C2orf44 CADM4 CRY1 DVL1 DVL2 DVL3 FAM110A FAM110C FAM83D FBP1 GTF3C1 HES1 KAT7 MCC NCOA3 PER1 PER2 PER3 PNO1 PPP1CA PPP1R14A RAD54B RBX1 SDCCAG3 SOCS3 TAOK1 TAZ TNS2 ZMYND8 ZNF227
Entrez ID		57551	1454
HPRD ID		15467	02919
Ensembl ID		ENSG00000160551	ENSG00000213923
Uniprot IDs		Q7L7X3	B0QY34 P49674 Q5U045
PDB IDs			4HNI 4HOK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Positive Regulation Of Metanephric Ureteric Bud Development Thorax And Anterior Abdomen Determination Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Adrenal Cortex Formation Negative Regulation Of Glomerulus Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Zygotic Determination Of Anterior/posterior Axis, Embryo Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Female Gonad Development Cardiac Muscle Cell Fate Commitment Metanephric S-shaped Body Morphogenesis Regulation Of Glomerular Mesangial Cell Proliferation Wnt Signaling Pathway S-shaped Body Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Diaphragm Development Protein Phosphorylation RNA Splicing Positive Regulation Of Male Gonad Development Regulation Of Female Gonad Development Seminiferous Tubule Development Glomerular Basement Membrane Development Glomerular Visceral Epithelial Cell Differentiation Movement Of Cell Or Subcellular Component Muscle Cell Fate Commitment Mesenchymal To Epithelial Transition Metanephric Mesenchyme Development Sertoli Cell Development Anterior/posterior Axis Specification, Embryo Sex Determination Cellular Response To Gonadotropin Stimulus Metanephric Nephron Morphogenesis	Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Regulation Of Wnt Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Wnt Signaling Pathway Regulation Of Phosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Phosphorus Metabolic Process Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Intracellular Signal Transduction Wnt Signaling Pathway Signaling Regulation Of JNK Cascade Circadian Rhythm Cell Communication Canonical Wnt Signaling Pathway Regulation Of Stress-activated MAPK Cascade Planar Cell Polarity Pathway Involved In Neural Tube Closure Cochlea Development Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Positive Regulation Of JNK Cascade Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Protein Metabolic Process Regulation Of Epithelial Cell Differentiation Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Kinase Activity Regulation Of Cell Differentiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stimulus Wnt Signaling Pathway, Planar Cell Polarity Pathway Epithelium Development Positive Regulation Of Metabolic Process Entrainment Of Circadian Clock By Photoperiod
Tagcloud ?		adamts16 ambiguous biopsies capacities cen17 cish commercially concordance copy deserves diploidy embedded expensive fish french gold ish lap3 mks1 mrm1 paraffin participating polysomy primer qpcr sish sstr2 tsn utp6	accessible applicable cancerous chosen constitute crc ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs polb ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a
Tagcloud (Difference) ?		adamts16 ambiguous biopsies capacities cen17 cish commercially concordance copy deserves diploidy embedded expensive fish french gold ish lap3 mks1 mrm1 paraffin participating polysomy primer qpcr sish sstr2 tsn utp6	accessible applicable cancerous chosen constitute crc ctnnb1 hct ihc integrated isogenic kill leave lethality msh2 pairs polb ranked rb1 rko rnai sl synergistically therapeutics top tp53 uncovering verified wnt5a
Tagcloud (Intersection) ?