PTK7 and DUSP10

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		PTK7	DUSP10
Description		protein tyrosine kinase 7 (inactive)	dual specificity phosphatase 10
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Axon Neuronal Cell Body Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Coreceptor Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity JUN Kinase Binding Hydrolase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity Mitogen-activated Protein Kinase P38 Binding
	Biological Process	Establishment Of Planar Polarity Kidney Development Neural Tube Closure Ventricular Septum Development Axis Elongation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Axon Guidance Heart Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Actin Cytoskeleton Organization Wound Healing Establishment Of Epithelial Cell Apical/basal Polarity Synapse Organization Convergent Extension Lung-associated Mesenchyme Development Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cellular Response To Retinoic Acid Cochlea Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Immune System Process Regulation Of Adaptive Immune Response Signal Transduction Negative Regulation Of Epithelial Cell Migration Dephosphorylation Negative Regulation Of Cell Migration Response To Lipopolysaccharide Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of JNK Cascade Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Process Stress-activated MAPK Cascade Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of Cell Development Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Brown Fat Cell Differentiation Negative Regulation Of P38MAPK Cascade Negative Regulation Of Epithelium Regeneration
Pathways			RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778)	Cluster headache ( 34184781) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal cancer ( 20972440 24836286 25990418 29471430) Colorectal cancer or advanced adenoma ( 30510241) Copper levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Progressive supranuclear palsy ( 30089514) Serum thyroid-stimulating hormone levels ( 25436638) Tonsillectomy ( 27182965 28928442) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		41 interacting genes: CDC14A CLNK CTDSP2 CYSRT1 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 ERBB2 ILKAP KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP5-9 MDFI MTMR1 MTMR10 MTMR6 MTMR9 MTUS2 NBPF19 NOTCH2NLA PPM1A PPM1B PPM1F PPM1K PPP3CA PPP3CB PTEN PTPN11 PTPN12 PTPN6 PTPN7 PTPRR STYX TPTE TPTE2	21 interacting genes: CMTM6 CNKSR1 ERBB4 FHL2 FN1 FNDC3B HOXA1 HTT IGF1R KRTAP3-2 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 PTK7 ROR2 RPS11 SLX1B SNX2
Entrez ID		5754	11221
HPRD ID		03534	12320
Ensembl ID		ENSG00000112655	ENSG00000143507
Uniprot IDs		Q13308	Q9Y6W6
PDB IDs		6VG3	1ZZW 2OUC 2OUD 3TG1 6MC1 7U4O 7U4R 7UMU 7UMV 7UN0 7UN4 7Y4B 7Y4C 7Y4D 7Y4E
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Protein Modification Process MAP Kinase Phosphatase Activity Phosphatidylinositol Dephosphorylation Regulation Of MAPK Cascade Cytoplasm Phospholipid Dephosphorylation Regulation Of Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Epithelial Cell Migration Cytosol Phosphatidylinositol Metabolic Process N-terminal Protein Myristoylation Regulation Of Epithelial Cell Migration Negative Regulation Of T Cell Proliferation Negative Regulation Of Signaling Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Phosphatidylinositol Dephosphorylation Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Regulation Of Lymphocyte Activation Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Neutrophil Activation Negative Regulation Of Developmental Growth Regulation Of Oligodendrocyte Differentiation	MAP Kinase Activity Protein Kinase Activity Kinase Activity JUN Kinase Activity Cellular Senescence Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Protein Phosphorylation Protein Serine Kinase Activity ATP Binding Phosphorylation MAPK Cascade Positive Regulation Of Cellular Component Organization Protein Serine/threonine Kinase Activity Positive Regulation Of Cyclase Activity Fc-epsilon Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Canonical Inflammasome Complex Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Autophosphorylation Regulation Of Cardiac Muscle Cell Proliferation Transferase Activity Nucleotide Binding Peptidyl-tyrosine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Activity NLRP1 Inflammasome Complex Assembly Response To Light Stimulus Fc Receptor Signaling Pathway Outer Ear Morphogenesis Peptidyl-tyrosine Autophosphorylation JNK Cascade Intracellular Signaling Cassette Regulation Of Heart Growth Positive Regulation Of Telomere Maintenance Enzyme-linked Receptor Protein Signaling Pathway Axon Cellular Response To UV-B MAP Kinase Kinase Activity Response To Radiation Regulation Of Organ Growth Protein Phosphatase Binding Positive Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process Protein Metabolic Process Response To UV-B Establishment Of Planar Polarity ERBB2 Signaling Pathway Positive Regulation Of Organelle Organization Insulin Receptor Binding Regulation Of Telomere Maintenance
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