PTK7 and MTMR1

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		PTK7	MTMR1
Description		protein tyrosine kinase 7 (inactive)	myotubularin related protein 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Axon Neuronal Cell Body Anchoring Junction	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Coreceptor Activity	Phosphatidylinositol-3-phosphate Phosphatase Activity Hydrolase Activity Protein Homodimerization Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Phosphatidylinositol Phosphate Phosphatase Activity
	Biological Process	Establishment Of Planar Polarity Kidney Development Neural Tube Closure Ventricular Septum Development Axis Elongation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Axon Guidance Heart Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Actin Cytoskeleton Organization Wound Healing Establishment Of Epithelial Cell Apical/basal Polarity Synapse Organization Convergent Extension Lung-associated Mesenchyme Development Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cellular Response To Retinoic Acid Cochlea Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Protein Destabilization Phosphatidylinositol Dephosphorylation Regulation Of Phosphatidylinositol Dephosphorylation
Pathways			Synthesis of PIPs at the plasma membrane RHOF GTPase cycle
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778)	Mean platelet volume ( 32888494)
Interacting Genes		41 interacting genes: CDC14A CLNK CTDSP2 CYSRT1 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 ERBB2 ILKAP KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP5-9 MDFI MTMR1 MTMR10 MTMR6 MTMR9 MTUS2 NBPF19 NOTCH2NLA PPM1A PPM1B PPM1F PPM1K PPP3CA PPP3CB PTEN PTPN11 PTPN12 PTPN6 PTPN7 PTPRR STYX TPTE TPTE2	3 interacting genes: ERBB3 PTK7 ROR2
Entrez ID		5754	8776
HPRD ID		03534	02163
Ensembl ID		ENSG00000112655	ENSG00000063601
Uniprot IDs		Q13308	B7Z3D5 E9PPP8 F8WA39 Q13613 Q8NEC6
PDB IDs		6VG3	5C16
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Protein Modification Process MAP Kinase Phosphatase Activity Phosphatidylinositol Dephosphorylation Regulation Of MAPK Cascade Cytoplasm Phospholipid Dephosphorylation Regulation Of Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Epithelial Cell Migration Cytosol Phosphatidylinositol Metabolic Process N-terminal Protein Myristoylation Regulation Of Epithelial Cell Migration Negative Regulation Of T Cell Proliferation Negative Regulation Of Signaling Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Phosphatidylinositol Dephosphorylation Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Regulation Of Lymphocyte Activation Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Neutrophil Activation Negative Regulation Of Developmental Growth Regulation Of Oligodendrocyte Differentiation	Mesenchyme Development Protein Kinase Activity Coreceptor Activity Wound Healing Protein Tyrosine Kinase Activity Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Receptor Complex Response To Wounding ATP Binding Neuregulin Receptor Activity Heart Development ErbB-3 Class Receptor Binding Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Wnt Signaling Pathway Schwann Cell Differentiation ERBB2-ERBB3 Signaling Pathway Cell Surface Receptor Signaling Pathway ERBB3 Signaling Pathway Axon Lung-associated Mesenchyme Development Negative Regulation Of Motor Neuron Apoptotic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Receptor Activity Endocardial Cushion Development Convergent Extension Positive Regulation Of Striated Muscle Tissue Development Regulation Of Motor Neuron Apoptotic Process Enzyme-linked Receptor Protein Signaling Pathway Kinase Activity Schwann Cell Development Motor Neuron Apoptotic Process ERBB2 Signaling Pathway Protein Tyrosine Kinase Activator Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Mitogen-activated Protein Kinase Kinase Kinase Binding Establishment Of Planar Polarity Establishment Of Apical/basal Cell Polarity Axis Elongation Establishment Of Monopolar Cell Polarity Establishment Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Peripheral Nervous System Development Coronary Vasculature Development Cochlea Morphogenesis Wnt-protein Binding Tissue Development Establishment Of Epithelial Cell Polarity
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