PTK7 and MTMR6

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		PTK7	MTMR6
Description		protein tyrosine kinase 7 (inactive)	myotubularin related protein 6
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Axon Neuronal Cell Body Anchoring Junction	Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Coreceptor Activity	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity
	Biological Process	Establishment Of Planar Polarity Kidney Development Neural Tube Closure Ventricular Septum Development Axis Elongation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Axon Guidance Heart Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Actin Cytoskeleton Organization Wound Healing Establishment Of Epithelial Cell Apical/basal Polarity Synapse Organization Convergent Extension Lung-associated Mesenchyme Development Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cellular Response To Retinoic Acid Cochlea Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway	Protein Dephosphorylation Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation
Pathways			Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778)	Metabolite levels ( 31628463) Triglyceride levels ( 32203549)
Interacting Genes		41 interacting genes: CDC14A CLNK CTDSP2 CYSRT1 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 ERBB2 ILKAP KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP5-9 MDFI MTMR1 MTMR10 MTMR6 MTMR9 MTUS2 NBPF19 NOTCH2NLA PPM1A PPM1B PPM1F PPM1K PPP3CA PPP3CB PTEN PTPN11 PTPN12 PTPN6 PTPN7 PTPRR STYX TPTE TPTE2	14 interacting genes: AATK ALKBH4 AMOTL2 ERBB3 ERBB4 LMTK2 MTMR9 MTNR1B MTUS2 NMI PTK7 RARG ROR2 TRIM27
Entrez ID		5754	9107
HPRD ID		03534	11946
Ensembl ID		ENSG00000112655	ENSG00000139505
Uniprot IDs		Q13308	A0A9L9PXJ0 Q9Y217
PDB IDs		6VG3	2YF0
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Protein Modification Process MAP Kinase Phosphatase Activity Phosphatidylinositol Dephosphorylation Regulation Of MAPK Cascade Cytoplasm Phospholipid Dephosphorylation Regulation Of Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Epithelial Cell Migration Cytosol Phosphatidylinositol Metabolic Process N-terminal Protein Myristoylation Regulation Of Epithelial Cell Migration Negative Regulation Of T Cell Proliferation Negative Regulation Of Signaling Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Phosphatidylinositol Dephosphorylation Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Regulation Of Lymphocyte Activation Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Neutrophil Activation Negative Regulation Of Developmental Growth Regulation Of Oligodendrocyte Differentiation	Neuregulin Receptor Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Wnt Signaling Pathway Kinase Activity ERBB2 Signaling Pathway Establishment Of Planar Polarity Regulation Of Type I Interferon Production Transferase Activity ATP Binding Receptor Complex Cell Surface Receptor Signaling Pathway Animal Organ Development Transmembrane Receptor Protein Tyrosine Kinase Activity Establishment Of Planar Polarity Involved In Nephron Morphogenesis Protein Sumoylation Negative Regulation Of Type I Interferon Production DNA N6-methyladenine Demethylase Activity Positive Regulation Of Cardiac Muscle Tissue Development Heart Development ERBB3:ERBB2 Complex Basal Plasma Membrane Mesenchyme Development Epidermal Growth Factor Receptor Signaling Pathway Central Nervous System Morphogenesis Cell Surface Receptor Signaling Pathway Via JAK-STAT Coreceptor Activity Cellular Response To Retinoic Acid Protein Polyubiquitination Regulation Of Interferon-beta Production Myosin VI Binding Cleavage Furrow Ingression Wound Healing ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication ErbB-3 Class Receptor Binding Neuron Apoptotic Process Neuregulin Binding Regulation Of Cardiac Muscle Tissue Development Cardiac Muscle Tissue Regeneration Developmental Growth Olfactory Bulb Interneuron Differentiation ERBB2-ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Activity Melatonin Receptor Activity Regulation Of Neuronal Action Potential Camera-type Eye Development Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep
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